Drug Discovery@nature.com 10 January 2014

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TABLE OF CONTENTS 10 January 2014 News Analysis Research Highlights Research & Reviews Careers Nature Reviews Drug Discovery is on Twitter Advertisement Nature Medicine Focus on Targeted Cancer Therapies In this special Focus, Nature Medicine is proud to present a collection of Reviews and a Perspective tackling some of the most exciting issues in translational cancer research, discussing recent advances and providing a view of what to expect in the near future.  Click here to access this Focus for free by visiting! Sponsored by:  Genentech    News Top Multicompany trials adapt to disciplines beyond cancer doi:10.1038/nm0114-3 Clinical researchers are catching on to the benefits of 'master protocol' trials that randomize patients to therapies from multiple companies. Full Text Revved-up epigenetic sequencing may foster new diagnostics doi:10.1038/nm0114-2 Recent innovations could allow researchers to find where methyl groups lie on specific genes more cheaply and more quickly. Full Text Projects set to tackle neglected diseases doi:10.1038/505142a But they do little to alter the process of drug development. Full Text An Audience With… Gigi Hirsch doi:10.1038/nrd4217 With European regulators preparing to launch an adaptive licensing pilot programme, Gigi Hirsch, from MIT, discusses the promise of a more flexible approach to drug approval. Full Text Analysis Top Oral nanoparticles doi:10.1038/scibx.2013.1371 A US research team has developed targeted nanoparticles that could enable the oral delivery of biologics. Translation of the approach will require identifying a suitable therapeutic payload and fine-tuning the pharmacology of the system. Full Text UK academic drug discovery doi:10.1038/nrd4200 This article presents a survey of the academic drug discovery environment in the United Kingdom in 2013, and discusses the major trends in comparison with the United States. Full Text Research Highlights Top Viral diseases: Zeroing in on RSV vaccine design doi:10.1038/nrd4207 Structure-based design produces a novel vaccine for respiratory syncytial virus, which shows a high level of neutralizing activity in mice and rhesus macaques. Full Text Antibacterial drugs: Persisters come under fire doi:10.1038/nrd4215 Two studies report novel approaches to eradicate bacterial persisters, which complicate the treatment of chronic infections as they are recalcitrant to killing by antibiotics. Full Text A step closer to elimination? doi:10.1038/nrd4216 A group of scientists from academia and industry report the discovery of a new class of antimalarials with promising preventive, therapeutic and transmission-blocking activity. Full Text Research & Reviews Top Therapeutic targeting of EPH receptors and their ligands doi:10.1038/nrd4175 EPH receptor (EPH)–ephrin signalling has crucial roles in embryonic development, as well as in adult tissue and organ maintenance, regeneration and pathogenesis. This article discusses the potential and limitations of targeting EPH–ephrin function in the treatment of disorders including cancer, neurological diseases and inflammation. Full Text The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment doi:10.1038/nrd4161 The Hippo signalling pathway is an emerging growth control pathway with roles in organ growth control, stem cell function, regeneration and tumour suppression. This article reviews the regulation and functions of the Hippo signalling pathway, focusing on its potential to be therapeutically targeted in the treatment of cancer as well as tissue repair and regeneration following injury. Full Text Tetraspanin proteins promote multiple cancer stages doi:10.1038/nrc3640 This Review discusses recent evidence, particularly from mouse models, showing that some tetraspanin proteins have important roles in tumour initiation, promotion, metastasis and angiogenesis, and that they might therefore be valid therapeutic targets. Full Text Ribosome-targeting antibiotics and mechanisms of bacterial resistance doi:10.1038/nrmicro3155 The ribosome is one of the primary antibiotic targets in the bacterial cell. This review discusses how high-resolution crystal structures of antibiotic–ribosome complexes have provided molecular insight into the mechanisms of antibiotic action and bacterial resistance, in addition to the approaches being pursued for the development of improved and novel ribosome-targeting antibiotics. Full Text Drug Discovery JOBS of the week Development of novel treatment for drug-resistant leukemia Oslo University Hospital Post-doctoral Position in Drug Discovery Inserm (French Institute of Health and Medical Research) Staff Scientist - Aerosol Drug Delivery Wyss Institute for Biologically Inspired Engineering Computational / Medicinal Chemist U.S. Environmental Protection Agency More Science jobs from Drug Discovery EVENT 20th International Symposium on Microsomes and Drug Oxidations (MDO) 22.05.14 Leinfelden-Echterdingen, Germany More science events from Careers Top Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. Full Text Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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