The EDGE

Nuclear worker studies: promise and pitfalls

R Wakeford

Br J Cancer 2014 110: 1-3; advance online publication, November 14, 2013; 10.1038/bjc.2013.713

Ethnic variation in breast cancer incidence and outcomes—the debate continues

A Januszewski, N Tanna and J Stebbing

Br J Cancer 2014 110: 4-6; 10.1038/bjc.2013.775

Minireview

Infection transmission and chronic disease models in the study of infection-associated cancers

I Baussano, S Franceschi and M Plummer

Br J Cancer 2014 110: 7-11; advance online publication, December 3, 2013; 10.1038/bjc.2013.740

Clinical Studies

Recognition of cancer warning signs and anticipated delay in help-seeking in a population sample of adults in the UK

S L Quaife, L J L Forbes, A J Ramirez, K E Brain, C Donnelly, A E Simon and J Wardle

Br J Cancer 2014 110: 12-18; advance online publication, October 31, 2013; 10.1038/bjc.2013.684

Extramural venous invasion is a potential imaging predictive biomarker of neoadjuvant treatment in rectal cancer

M Chand, R I Swift, P P Tekkis, I Chau and G Brown

Br J Cancer 2014 110: 19-25; advance online publication, December 3, 2013; 10.1038/bjc.2013.603

Analysis of plasma cytokines and angiogenic factors in patients with pretreated urothelial cancer receiving Pazopanib: the role of circulating interleukin-8 to enhance the prognostic accuracy

A Necchi, M Pennati, N Zaffaroni, E Landoni, P Giannatempo, D Raggi, L H Schwartz, C Morosi, F Crippa, E Farè, N Nicolai, R Lanocita, T Sava, C Sacco, C Messina, C Ortega, F G De Braud, R Salvioni, M G Daidone, A M Gianni and L Mariani

Br J Cancer 2014 110: 26-33; advance online publication, November 14, 2013; 10.1038/bjc.2013.719

Preoperative nomogram for the identification of lymph node metastasis in early cervical cancer

D-Y Kim, S-H Shim, S-O Kim, S-W Lee, J-Y Park, D-S Suh, J-H Kim, Y-M Kim, Y-T Kim and J-H Nam

Br J Cancer 2014 110: 34-41; advance online publication, November 14, 2013; 10.1038/bjc.2013.718

External validation of three prognostic models for overall survival in patients with advanced-stage epithelial ovarian cancer

R van de Laar, J IntHout, T Van Gorp, S Verdonschot, A M van Altena, C G Gerestein, L F A G Massuger, P L M Zusterzeel and R F P M Kruitwagen

Br J Cancer 2014 110: 42-48; advance online publication, November 19, 2013; 10.1038/bjc.2013.717

Late toxicities after intensity-modulated radiotherapy for nasopharyngeal carcinoma: patient and treatment-related risk factors

L Zeng, Y-M Tian, X-M Sun, C-Y Chen, F Han, W-W Xiao, X-W Deng and T-X Lu

Br J Cancer 2014 110: 49-54; advance online publication, November 19, 2013; 10.1038/bjc.2013.720

First-line gefitinib in Caucasian EGFR mutation-positive NSCLC patients: a phase-IV, open-label, single-arm study

J-Y Douillard, G Ostoros, M Cobo, T Ciuleanu, R McCormack, A Webster and T Milenkova

Br J Cancer 2014 110: 55-62; advance online publication, November 21, 2013; 10.1038/bjc.2013.721

Translational Therapeutics

An anti-leishmanial thiadiazine agent induces multiple myeloma cell apoptosis by suppressing the nuclear factor kappaB signalling pathway

G Chen, K Han, X Xu, X Du, Z Zhang, J Tang, M Shi, M Wang, J Li, B Cao and X Mao

Br J Cancer 2014 110: 63-70; advance online publication, November 14, 2013; 10.1038/bjc.2013.711

Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation

Y Zhang, S Dayalan Naidu, K Samarasinghe, G C Van Hecke, A Pheely, T N Boronina, R N Cole, I J Benjamin, P A Cole, Y-H Ahn and A T Dinkova-Kostova

Br J Cancer 2014 110: 71-82; advance online publication, December 5, 2013; 10.1038/bjc.2013.710

Gemcitabine enhances the efficacy of reovirus-based oncotherapy through anti-tumour immunological mechanisms

S A Gujar, D Clements, R Dielschneider, E Helson, P Marcato and P W K Lee

Br J Cancer 2014 110: 83-93; advance online publication, November 26, 2013; 10.1038/bjc.2013.695

The potential application of a transcriptionally regulated oncolytic herpes simplex virus for human cancer therapy

L Miao, C Fraefel, K C Sia, J P Newman, S A Mohamed-Bashir, W H Ng and P Y P Lam

Br J Cancer 2014 110: 94-106; advance online publication, November 5, 2013; 10.1038/bjc.2013.692

Molecular Diagnostics

Increased microvascular proliferation is negatively correlated to tumour blood flow and is associated with unfavourable outcome in endometrial carcinomas

I S Haldorsen, I Stefansson, R Grüner, J A Husby, I J Magnussen, H M J Werner, Ø O Salvesen, L Bjørge, J Trovik, T Taxt, L A Akslen and H B Salvesen

Br J Cancer 2014 110: 107-114; advance online publication, October 31, 2013; 10.1038/bjc.2013.694

An expression signature of the angiogenic response in gastrointestinal neuroendocrine tumours: correlation with tumour phenotype and survival outcomes

D J Pinato, T M Tan, S T K Toussi, R Ramachandran, N Martin, K Meeran, N Ngo, R Dina and R Sharma

Br J Cancer 2014 110: 115-122; advance online publication, November 14, 2013; 10.1038/bjc.2013.682

Identification of candidate circulating cisplatin-resistant biomarkers from epithelial ovarian carcinoma cell secretomes

P-N Teng, G Wang, B L Hood, K A Conrads, C A Hamilton, G L Maxwell, K M Darcy and T P Conrads

Br J Cancer 2014 110: 123-132; advance online publication, October 31, 2013; 10.1038/bjc.2013.687

Granulocyte colony-stimulating factor receptor signalling via Janus kinase 2/signal transducer and activator of transcription 3 in ovarian cancer

J Kumar, F W Fraser, C Riley, N Ahmed, D R McCulloch and A C Ward

Br J Cancer 2014 110: 133-145; advance online publication, November 12, 2013; 10.1038/bjc.2013.673

Intracellular patterns of sialophorin expression define a new molecular classification of breast cancer and represent new targets for therapy

Q Fu, S E Cash, J J Andersen, C R Kennedy, A R Madadi, M Raghavendra, L L Dietrich, W A Agger and C S Shelley

Br J Cancer 2014 110: 146-155; advance online publication, November 26, 2013; 10.1038/bjc.2013.526

Fucosylated TGF-β receptors transduces a signal for epithelial–mesenchymal transition in colorectal cancer cells

M Hirakawa, R Takimoto, F Tamura, M Yoshida, M Ono, K Murase, Y Sato, T Osuga, T Sato, S Iyama, K Miyanishi, K Takada, T Hayashi, M Kobune and J Kato

Br J Cancer 2014 110: 156-163; advance online publication, November 19, 2013; 10.1038/bjc.2013.699

Amplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers

Y Takahashi, G Sawada, J Kurashige, R Uchi, T Matsumura, H Ueo, Y Takano, H Eguchi, T Sudo, K Sugimachi, H Yamamoto, Y Doki, M Mori and K Mimori

Br J Cancer 2014 110: 164-171; advance online publication, November 5, 2013; 10.1038/bjc.2013.698

Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia

M Maftouh, A Avan, R Sciarrillo, C Granchi, L G Leon, R Rani, N Funel, K Smid, R Honeywell, U Boggi, F Minutolo, G J Peters and E Giovannetti

Br J Cancer 2014 110: 172-182; advance online publication, October 31, 2013; 10.1038/bjc.2013.681

Validation of C-reactive protein levels as a prognostic indicator for survival in a large cohort of pancreatic cancer patients

J Szkandera, M Stotz, G Absenger, T Stojakovic, H Samonigg, P Kornprat, R Schaberl-Moser, W AlZoughbi, C Lackner, A L Ress, F S Seggewies, A Gerger, G Hoefler and M Pichler

Br J Cancer 2014 110: 183-188; advance online publication, November 7, 2013; 10.1038/bjc.2013.701

MicroRNA-133a regulates the mRNAs of two invadopodia-related proteins, FSCN1 and MMP14, in esophageal cancer

N Akanuma, I Hoshino, Y Akutsu, K Murakami, Y Isozaki, T Maruyama, G Yusup, W Qin, T Toyozumi, M Takahashi, H Suito, X Hu, N Sekino and H Matsubara

Br J Cancer 2014 110: 189-198; advance online publication, November 5, 2013; 10.1038/bjc.2013.676

Expression of nuclear survivin in normal skin and squamous cell carcinoma: a possible role in tumour invasion

K Dallaglio, T Petrachi, A Marconi, F Truzzi, R Lotti, A Saltari, P Morandi, M Puviani, A Maiorana and C Pincelli

Br J Cancer 2014 110: 199-207; advance online publication, November 5, 2013; 10.1038/bjc.2013.697

Epidemiology

Inflammation as a validated prognostic determinant in carcinoma of unknown primary site

Z Mohamed, D J Pinato, F A Mauri, K-W Chen, P M-H Chang and R Sharma

Br J Cancer 2014 110: 208-213; advance online publication, October 29, 2013; 10.1038/bjc.2013.683

A reanalysis of cancer mortality in Canadian nuclear workers (1956–1994) based on revised exposure and cohort data

L B Zablotska, R S D Lane and P A Thompson

Br J Cancer 2014 110: 214-223; advance online publication, November 14, 2013; 10.1038/bjc.2013.592

Ethnic differences in breast cancer incidence in England are due to differences in known risk factors for the disease: prospective study

T Gathani, R Ali, A Balkwill, J Green, G Reeves, V Beral and K A Moser on behalf of the Million Women Study Collaborators

Br J Cancer 2014 110: 224-229; advance online publication, October 29, 2013; 10.1038/bjc.2013.632

Ethnicity and outcome of young breast cancer patients in the United Kingdom: the POSH study

E Copson, T Maishman, S Gerty, B Eccles, L Stanton, R I Cutress, D G Altman, L Durcan, P Simmonds, L Jones, W Tapper, POSH study steering group and Diana Eccles

Br J Cancer 2014 110: 230-241; advance online publication, October 22, 2013; 10.1038/bjc.2013.650

Cigarette smoking, alcohol intake, and risk of glioma in the NIH-AARP Diet and Health Study

M Z Braganza, P Rajaraman, Y Park, P D Inskip, N D Freedman, A R Hollenbeck, A Berrington de González and C M Kitahara

Br J Cancer 2014 110: 242-248; advance online publication, December 12, 2013; 10.1038/bjc.2013.611

Long-term use of multivitamins and risk of colorectal adenoma in women

J Massa, E Cho, E J Orav, W C Willett, K Wu and E L Giovannucci

Br J Cancer 2014 110: 249-255; advance online publication, November 12, 2013; 10.1038/bjc.2013.664

Second cancer risk and mortality in men treated with radiotherapy for stage I seminoma

A Horwich, S D Fossa, R Huddart, D P Dearnaley, S Stenning, M Aresu, J M Bliss and E Hall

Br J Cancer 2014 110: 256-263; advance online publication, November 21, 2013; 10.1038/bjc.2013.551

Letters to the Editor

Comment on ‘Chemotherapy for testicular cancer induces acute alterations in diastolic heart function’

K-P Dieckmann

Br J Cancer 2014 110: 264-265; advance online publication, November 7, 2013; 10.1038/bjc.2013.703

Reply: Comment on ‘Chemotherapy for testicular cancer induces acute alterations in diastolic heart function’

L D van Schinkel, P M Willemse, R W van der Meer, J Burggraaf, S G C van Elderen, J W A Smit, A de Roos, S Osanto and H J Lamb

Br J Cancer 2014 110: 265; advance online publication, November 7, 2013; 10.1038/bjc.2013.704

Comment on ‘Anti-tumour activity of abiraterone and diethylstilboestrol when administered sequentially to men with castration-resistant prostate cancer’

J Shamash and S-J Sarker

Br J Cancer 2014 110: 266-267; advance online publication, December 3, 2013; 10.1038/bjc.2013.736

Reply: ‘Comment on Anti-tumour activity of abiraterone and diethylstilboestrol when administered sequentially to men with castration-resistant prostate cancer’

A Omlin, C J Pezaro, S Zaidi, D Lorente, D Mukherji, D Bianchini, R Ferraldeschi, S Sandhu, D Dearnaley, C Parker, N Van As, J S de Bono and G Attard

Br J Cancer 2014 110: 267-268; advance online publication, December 3, 2013; 10.1038/bjc.2013.737