The EMBO Journal - Table of Contents alert Volume 32 Issue 24

Advertisement Circulation: Cardiovascular Genetics is the #1 journal dedicated to cardiovascular genetics, genomics, proteomics, metabolomics, and systems biology. Join an esteemed roster of your peers - submit your paper for publication in Circulation: Cardiovascular Genetics today. Visit the journal's Information for Authors to learn about preferred article types and how to submit. TABLE OF CONTENTS 11 December 2013 | Volume 32, Issue 24 Commentary Obituary Have you seen? Articles Recommend to your library Advertisement EMBO Press launches this month, uniting the policies and initiatives of The EMBO Journal, EMBO reports, EMBO Molecular Medicine and Molecular Systems Biology. Our vision is to make science publishing more transparent, and to transform articles into data-enriched, accessible records of research. The journals continue to select important work from the global life sciences community for publication.    Commentary Top European stem cell research in legal shackles This commentary critically discusses potential legal uncertainty that may impact the patentability/translation of particularly stem cell-based therapeutics. Myrthe G Nielen, Sybe A de Vries and Niels Geijsen The EMBO Journal (2013), 32, 3107 - 3111; 10.1038/emboj.2013.249 Abstract | Full text | PDF Published online: 22 November 2013 Obituary Top Remembering Michael S Neuberger (1953–2013) Antonino Cattaneo and Roberto Sitia The EMBO Journal (2013), 32, 3112 - 3113; 10.1038/emboj.2013.251 Full text | PDF Published online: 11 December 2013 Have you seen? Top Cohesin’s role as an active chromatin domain anchorage revealed High-resolution chromatin conformation capture combined with functional methods reveal a novel cohesin function as critical determinant of the chromosomal architecture. Christine Feig and Duncan T Odom The EMBO Journal (2013), 32, 3114 - 3115; 10.1038/emboj.2013.248 Abstract | Full text | PDF | Related article Published online: 22 November 2013 Amphisomes: out of the autophagosome shadow? Amphisomes are intermediate organelles formed during autophagy. Stappenbeck and colleagues now report that amphisome-like compartments regulate mucin secretion in goblet cells. Jana Sanchez-Wandelmer and Fulvio Reggiori The EMBO Journal (2013), 32, 3116 - 3118; 10.1038/emboj.2013.246 Abstract | Full text | PDF | Related article Published online: 12 November 2013 Articles Top Cohesin-mediated interactions organize chromosomal domain architecture  EMBO Open Chromosomal compartmentalization has been recognized as important for genome function. High-resolution techniques such as Hi-C, ChIP- and 4C-seq offer novel insights into cohesin’s dynamic role in shaping the nuclear architecture. Sevil Sofueva, Eitan Yaffe, Wen-Ching Chan, Dimitra Georgopoulou, Matteo Vietri Rudan, Hegias Mira-Bontenbal, Steven M Pollard, Gary P Schroth, Amos Tanay and Suzana Hadjur The EMBO Journal (2013), 32, 3119 - 3129; 10.1038/emboj.2013.237 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 01 November 2013 Autophagy proteins control goblet cell function by potentiating reactive oxygen species production In vivo findings on mucus secretion in the colon illustrate how autophagy proteins can control secretion mechanisms via ROS generation. Khushbu K Patel, Hiroyuki Miyoshi, Wandy L Beatty, Richard D Head, Nicole P Malvin, Ken Cadwell, Jun-Lin Guan, Tatsuya Saitoh, Shizuo Akira, Per O Seglen, Mary C Dinauer, Herbert W Virgin and Thaddeus S Stappenbeck The EMBO Journal (2013), 32, 3130 - 3144; 10.1038/emboj.2013.233 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 01 November 2013 Transcriptome sequencing during mouse brain development identifies long non-coding RNAs functionally involved in neurogenic commitment Comprehensive gene-expression profiling of neural stem cells, differentiating progenitors and newborn neurons identify lncRNAs as novel players in corticogenesis. Julieta Aprea, Silvia Prenninger, Martina Dori, Tanay Ghosh, Laura Sebastian Monasor, Elke Wessendorf, Sara Zocher, Simone Massalini, Dimitra Alexopoulou, Mathias Lesche, Andreas Dahl, Matthias Groszer, Michael Hiller and Federico Calegari The EMBO Journal (2013), 32, 3145 - 3160; 10.1038/emboj.2013.245 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 15 November 2013 Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome  EMBO Open Isogenic pairs of patient-derived iPS- and ES-cell lines reveal the molecular problems contributing to cardiac arrest in long-QT syndrome. Milena Bellin, Simona Casini, Richard P Davis, Cristina D'Aniello, Jessica Haas, Dorien Ward-van Oostwaard, Leon G J Tertoolen, Christian B Jung, David A Elliott, Andrea Welling, Karl-Ludwig Laugwitz, Alessandra Moretti and Christine L Mummery The EMBO Journal (2013), 32, 3161 - 3175; 10.1038/emboj.2013.240 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 08 November 2013 Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis  EMBO Open Dose-dependent deletion of HDAC1 and -2 in the mouse epidermis reveals non-redundant functions in postnatal skin homeostasis. The novel tumour suppressive function of HDAC1 should caution the application of HDAC inhibitors as therapeutics. Mircea Winter, Mirjam A Moser, Dominique Meunier, Carina Fischer, Georg Machat, Katharina Mattes, Beate M Lichtenberger, Reinhard Brunmeir, Simon Weissmann, Christina Murko, Christina Humer, Tina Meischel, Gerald Brosch, Patrick Matthias, Maria Sibilia and Christian Seiser The EMBO Journal (2013), 32, 3176 - 3191; 10.1038/emboj.2013.243 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 15 November 2013 Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress Genotoxic agents induce hMOF-dependent acetylation of p53, enhancing association with the Microprocessor complex to facilitate miRNA biogenesis. This novel pathway is required to elicit p53-dependent apoptosis. Jonathan Chang, Brandi N Davis-Dusenbery, Risa Kashima, Xuan Jiang, Nisha Marathe, Roberto Sessa, Justin Louie, Wei Gu, Giorgio Lagna and Akiko Hata The EMBO Journal (2013), 32, 3192 - 3205; 10.1038/emboj.2013.242 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 12 November 2013 USP10 inhibits genotoxic NF-κB activation by MCPIP1-facilitated deubiquitination of NEMO The DNA damage-inducible protein MCPIP1 teams up with a deubiquitinating enzyme to cleave linear ubiquitin chains off NEMO. Jixiao Niu, Yuling Shi, Jingyan Xue, Ruidong Miao, Shengping Huang, Tianyi Wang, Jiong Wu, Mingui Fu and Zhao-Hui Wu The EMBO Journal (2013), 32, 3206 - 3219; 10.1038/emboj.2013.247 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 22 November 2013 Large cargo transport by nuclear pores: implications for the spatial organization of FG-nucleoporins Nuclear transport receptors (NTRs) engage in multivalent interactions with nuclear pore complexes (NPCs). Single-molecule fluorescence microscopy and quantitative modelling suggest that multiple NTRs are required for translocation of large cargo through the NPC. Li-Chun Tu, Guo Fu, Anton Zilman and Siegfried M Musser The EMBO Journal (2013), 32, 3220 - 3230; 10.1038/emboj.2013.239 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 08 November 2013 SERCA mutant E309Q binds two Ca2+ ions but adopts a catalytically incompetent conformation The sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) couples ATP hydrolysis to Ca2+ transport. A crystal structure shows that the E309Q mutant allows normal Ca2+ binding but disrupts long-range communication between ATP hydrolysis and gating. Johannes D Clausen, Maike Bublitz, Bertrand Arnou, Cédric Montigny, Christine Jaxel, Jesper Vuust Møller, Poul Nissen, Jens Peter Andersen and Marc le Maire The EMBO Journal (2013), 32, 3231 - 3243; 10.1038/emboj.2013.250 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 22 November 2013 Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. 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