Nature Reviews Genetics Contents January 2014 Volume 15 Number 1 pp 1-62

Advertisement
Finally! Antibodies you can TRUST.   Partnering with epigenetics experts including the BLUEPRINT Epigenome consortium, Diagenode has developed the absolute best epigenetics antibodies with the highest specificity and sensitivity available. Achieve unparalleled MeDIP, ChIP, and ChIP-seq results with validated antibodies you can trust. Learn more.
TABLE OF CONTENTS
January 2014 Volume 15 Number 1
Impact Factor 41.063 *	In this issue Research Highlights Ethics Watch Reviews Perspectives Also this month Article series: Non-coding RNA Applications of next-generation sequencing  Featured article: Epistasis and quantitative traits: using model organisms to study gene-gene interactions Trudy F. C. Mackay
Subscribe   Facebook   RSS   Recommend to library   Twitter
Advertisement
nature.com webcasts Macmillan Science Communication presents a custom webcast series: Drugging the Human Methylome Two independent, but complimentary, webcasts and live Q & A's broadcasting on:  21 January   23 January  Sponsored by:
RESEARCH HIGHLIGHTS Top Evolution: Transposons drive sex chromosome evolution p1 | doi:10.1038/nrg3635 PDF Development: Sharing enhancers for a different outcome p2 | doi:10.1038/nrg3636 PDF Disease genetics: Phenome-wide association studies go large p2 | doi:10.1038/nrg3637 PDF Gene regulation: RNA methylation regulates the circadian clock p3 | doi:10.1038/nrg3638 PDF Viral evolution: Flu host evasion p4 | doi:10.1038/nrg3639 PDF Genomics: Organ roles for mitochondrial mutations? p4 | doi:10.1038/nrg3640 PDF Stem cells: Competitive behaviour of cancer mutations p4 | doi:10.1038/nrg3641 PDF IN BRIEF Genome instabilty: Mechanisms of HPV integration | Genome editing: TALENs for microRNAs | Population genomics: Triallelic sites and demographic history | Development: A mechanical route to robustness | Technology: Characterizing CRISPR off-target effects | Genomics: Scaffolding DNA assemblies by 3D proximity | Networks: Integrating GWASs and protein interactions | Complex traits: Non-coding polymorphism in IRF4 reveals function PDF Genetics JOBS of the week Postdoc position in stem cells and epigenetics Mount Sinai School of Medicine Postdoctoral Scientists (Epigenetics) Structural Genomics Consortium (SGC) Postdoctoral Position at The Scripps Research Institute The Scripps Research Institute Research Technician Ontario Institute for Cancer Rese Postdoc in Stem Cell Biology and Embryogenesis Max Planck Institute for Molecular Genetics More Science jobs from Genetics EVENT Malaria Experimental Genetics 09.02.14 Cambridge, UK More science events from
ETHICS WATCH		Top
A big step for Finnish biobanking Joanna Stjernschantz Forsberg & Sirpa Soini p6 | doi:10.1038/nrg3646 Full Text | PDF
REVIEWS		Top
Article series: Non-coding RNA Long non-coding RNAs: new players in cell differentiation and development Alessandro Fatica & Irene Bozzoni p7 | doi:10.1038/nrg3606 Our knowledge of the diverse types and roles of long non-coding RNAs (lncRNAs) is rapidly increasing. This Review discusses our latest understanding of lncRNAs that have validated functional roles in various differentiation and developmental processes. Abstract | Full Text | PDF
Epistasis and quantitative traits: using model organisms to study gene-gene interactions Trudy F. C. Mackay p22 | doi:10.1038/nrg3627 The role of epistasis in quantitative traits is controversial. This Review argues that findings from studies of these traits are consistent with pervasive epistasis and discusses how experimental designs in model organisms are used to uncover the underlying genetic interactions. Abstract | Full Text | PDF
Systems genetics approaches to understand complex traits Mete Civelek & Aldons J. Lusis p34 | doi:10.1038/nrg3575 Complex organismal traits, including diseases, are controlled by intricate interactions between multiple genes, intermediate molecular and cellular phenotypes, and environmental influences. This Review describes how systems genetics integrates these layers of information to provide a cohesive understanding of the molecular underpinnings of complex traits. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Article series: Applications of next-generation sequencing Bacterial genome sequencing in the clinic: bioinformatic challenges and solutions W. Florian Fricke & David A. Rasko p49 | doi:10.1038/nrg3624 Bacterial whole-genome sequencing is showing promise in clinical applications. Here, the authors present their opinions on what the main bioinformatic challenges are in transferring bacterial whole-genome sequencing to medical diagnostics. Abstract | Full Text | PDF
OPINION Article series: Applications of next-generation sequencing The role of replicates for error mitigation in next-generation sequencing Kimberly Robasky, Nathan E. Lewis & George M. Church p56 | doi:10.1038/nrg3655 Next-generation sequencing for variant identification is now becoming widespread, although pipelines have not yet been optimized. In this Perspective article, the authors discuss ways to minimize erroneous variant calls, in particular, by using replicates. Abstract | Full Text | PDF | Supplementary information
Corrigendum: Advanced genetic tools for plant biotechnology Wusheng Liu, Joshua S. Yuan & C. Neal Stewart, Jr p62 | doi:10.1038/nrg3626 Full Text | PDF
Advertisement
NatureJournals app for iPad The NatureJournals app for iPad now boasts over 25 Nature-branded titles. Subscribe to any journal in the app for $35.99* and gain access to world class research on the move. www.nature.com/content/app/anytitleoffer *Apple exchange rates apply. Limited time offer available on all journals except Scientific Reports. iPad is a trademark of Apple Inc.
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

*2012 Journal Citation Report (Thomson Reuters, 2013)

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2014 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.