Molecular Systems Biology - New articles published 3 December 2013

Latest Articles 3rd December 2013   Featured Article Report   Web feeds About Open access Advertisement EMBO Press launches this month, uniting the policies and initiatives of Molecular Systems Biology, The EMBO Journal, EMBO reports and EMBO Molecular Medicine. Our vision is to make science publishing more transparent, and to transform articles into data-enriched, accessible records of research. The journals continue to select important work from the global life sciences community for publication.     Featured Article Timescales and bottlenecks in miRNA-dependent gene regulation Application of a kinetic model of miRNA-mediated gene regulation to experimental data sets shows that the timescale of regulation is slower than previously assumed, due to bottlenecks imposed by miRNA turnover in the RNA-induced silencing complex and by slow protein decay. Jean Hausser, Afzal Pasha Syed, Nathalie Selevsek, Erik van Nimwegen, Lukasz Jaskiewicz, Ruedi Aebersold & Mihaela Zavolan Molecular Systems Biology 9:711; doi:10.1038/msb.2013.68; published 3 December 2013 Full Text | PDF | Supp. Inf. | Review Process Report Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia The impact of oncogene activation and hypoxia on energy metabolism is analyzed by integrating quantitative measurements into a redox-balanced metabolic flux model. Glutamine-driven oxidative phosphorylation is found to be a major ATP source even in oncogene-expressing or hypoxic cells. Jing Fan, Jurre J Kamphorst, Robin Mathew, Michelle K Chung, Eileen White, Tomer Shlomi & Joshua D Rabinowitz Molecular Systems Biology 9:712; doi:10.1038/msb.2013.65; published 3 December 2013 Full Text | PDF | Supp. Inf. | Review Process     You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.