Nature Reviews Microbiology contents December 2013 Volume 11 Number 12 pp 815-891

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Professor Martin Klotz talks to us about what excites him about Microbiology, why he joined Frontiers in Microbiology as our Field Chief Editor, and where he sees the field going. Read our interview with Professor Klotz
TABLE OF CONTENTS
December 2013 Volume 11 Number 12
Impact Factor 22.49 *	In this issue Editorial Research Highlights News and Analysis Reviews Perspectives Also this month Article Series: Vector-borne diseases  Featured article: A decade after SARS: strategies for controlling emerging coronaviruses Rachel L. Graham, Eric F. Donaldson & Ralph S. Baric
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Nature Reviews Microbiology FOCUS ON PLANT-MICROBE INTERACTIONS This special Focus issue presents five Reviews from leading experts discussing the latest advances in our understanding of the relationship between bacterial, viral and eukaryotic filamentous pathogens and their plant hosts.  Read the Focus online.
EDITORIAL		Top
A broad rejuvenation p815 | doi:10.1038/nrmicro3174 As World AIDS Day approaches, and the 30th anniversary year of the isolation of HIV-1 draws to a close, it is timely to reflect on the past, present and future of HIV/AIDS research. Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Bacterial genetics: Defeating the drawbacks of CRISPR p817 | doi:10.1038/nrmicro3157 A study shows that bacteria can counteract CRISPR-Cas immunity against beneficial plasmids by inactivating or deleting CRISPR-Cas loci. PDF Bacterial evolution: Getting to the bottom of Cyanobacteria p818 | doi:10.1038/nrmicro3158 A metagenomic study of gut and environmental samples identifies a sibling phylum to Cyanobacteria, the non-photosynthetic Melainabacteria. PDF Fungal pathogenesis: Escaping elimination p818 | doi:10.1038/nrmicro3159 Batrachochytrium dendrobatidis releases soluble mycotoxins that inhibit Xenopus laevis lymphocyte proliferation by inducing caspase-mediated apoptosis. PDF Bacterial pathogenesis: CXCRs mark the spot p819 | doi:10.1038/nrmicro3162 This study shows that binding of leukotoxin ED to the chemokine receptors CXCR1 and CXCR2 on neutrophils is crucial for Staphylococcus aureus pathogenesis. PDF Antimicrobials: Silencing bacterial communication p820 | doi:10.1038/nrmicro3163 The identification of a quorum sensing antagonist that inhibits Pseudomonas aeruginosa virulence factor expression and biofilm formation. PDF Bacterial physiology: Vibrio uptake apparatus p820 | doi:10.1038/nrmicro3165 The first visualization and detailed characterization of the DNA-uptake apparatus that is involved in natural transformation in Vibrio cholerae. PDF IN BRIEF Cellular microbiology: c-di-AMP enters the riboswitch realm | Antimicrobials: Resistant bacteria show some sensitivity | Bacterial pathogenesis: Meningococcus warms up to immune evasion | Host response: RNAi: challenging the dogma | Techniques & applications: Bacteria in 3D | Structural biology: Type III CRISPR-Cas complexes in the spotlight | Virology: SARS-CoV ancestor found in Chinese bats PDF Microbiology JOBS of the week Professor of Microbiology Universidad San Francisco de Quito Postdoc - Microbiology: "Using CRISPR systems to study and fight pathogenic bacteria" Institut Pasteur Senior Bacteriologist Faculty Position University of Virginia Postdoctoral Positions Max Planck Institute for Terrestrial Microbiology Group Leader positions The International Center for Infectiology Research (CIRI) More Science jobs from Microbiology EVENT Clinical Virology Symposium 27.04.14 Florida, USA More science events from
NEWS AND ANALYSIS		Top
GENOME WATCH Playing fast and loose with mutation Alison E. Mather & Simon R. Harris p822 | doi:10.1038/nrmicro3164 This month's Genome Watch investigates the role of hypermutation in chronic bacterial infection and its implications for phylogenomic analyses. PDF
REVIEWS		Top
Targeting lipid biosynthesis and salvage in apicomplexan parasites for improved chemotherapies Isabelle Coppens p823 | doi:10.1038/nrmicro3139 Apicomplexan parasites have unique lipid-scavenging and -synthesis pathways that are not found in their mammalian hosts. Coppens gives an overview of these pathways in Plasmodium spp., Toxoplasma gondii and Cryptosporidium spp. and highlights promising drug targets to interfere with the parasites' high demand for isoprenoids, sphingolipids and cholesterol. Abstract | Full Text | PDF
A decade after SARS: strategies for controlling emerging coronaviruses Rachel L. Graham, Eric F. Donaldson & Ralph S. Baric p836 | doi:10.1038/nrmicro3143 The emergence of severe acute respiratory syndrome (SARS) coronavirus and, more recently, Middle East respiratory syndrome (MERS) coronavirus has highlighted the pathogenic and epidemic potential of this virus family. Here, Graham, Donaldson and Baric review key biological properties of coronaviruses and how to target them with potential therapeutics. Abstract | Full Text | PDF
Article series: Vector-borne diseases Antimalarial drug discovery — approaches and progress towards new medicines Erika L. Flannery, Arnab K. Chatterjee & Elizabeth A. Winzeler p849 | doi:10.1038/nrmicro3138 Current antimalarial therapy heavily relies on artemisinins, a drug class that only targets the blood stages of the parasite and which is increasingly feared to elicit drug resistance. Flannery, Chatterjee and Winzeler discuss the approaches used to develop novel drugs that are active against different life cycle stages with the ultimate aim of eliminating malaria. Abstract | Full Text | PDF
Keeping it quiet: chromatin control of gammaherpesvirus latency Paul M. Lieberman p863 | doi:10.1038/nrmicro3135 Epstein–Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) establish latent infections, during which the viral genomes are maintained in the host cell as viral episomes. As discussed by Lieberman, latency depends on numerous factors, including viral genome chromatinization and epigenetic modification, as well as tight control of the latency transcription programme. Abstract | Full Text | PDF
PERSPECTIVES		Top
TIMELINE Past, present and future: 30 years of HIV research Françoise Barré-Sinoussi, Anna Laura Ross & Jean-François Delfraissy p877 | doi:10.1038/nrmicro3132 The isolation of HIV-1 was a fundamental step for understanding HIV and the disease it causes. Here, Françoise Barré-Sinoussi, Anna Laura Ross and Jean-François Delfraissy look back on three decades of research that have changed the lives of people infected with HIV and have inspired hope for a cure. Abstract | Full Text | PDF
OPINION Development of vaccines for Candida albicans: fighting a skilled transformer Antonio Cassone p884 | doi:10.1038/nrmicro3156 Antonio Cassone outlines why he thinks univalent subunit vaccines targeting Candida albicans are unlikely to succeed and argues that the development of a multivalent vaccine could be a better approach. Abstract | Full Text | PDF
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*2012 Journal Citation Report (Thomson Reuters, 2013)

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