Nature Reviews Immunology Contents December 2013 Volume 13 Number 12 pp 839-902

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Mechanisms underlying CD4+ Treg immune regulation in the adult: from experiments to models (open access) In this mini-review published in Frontiers in Immunology Marta Caridade, Luis Graca and Ruy M. Ribeiro discuss some of the known and proposed mechanisms by which Tregs exert their influence in the context of immune regulation, and the contribution of mathematical modeling for these mechanistic studies.
TABLE OF CONTENTS
December 2013 Volume 13 Number 12
Impact Factor 33.129 *	In this issue Comment Research Highlights Reviews Correspondence Also this month  Featured article: Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy Richard S. Hotchkiss, Guillaume Monneret & Didier Payen
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Nature Methods  COLLECTION ON LIGHT-SHEET MICROSCOPY  The use of a planar sheet of light for illumination in light-sheet fluorescence microscopy allows researchers to image sample volumes faster than is possible with other current methods, while limiting light dosage. A collection of articles from Nature Methods, Nature Communications and Nature Reviews Molecular Cell Biology provides a brief overview of this exciting imaging technology and the biological research applications that it makes possible. Produced with support from:  Carl Zeiss Microscopy
Comment: Nobel Prize discovery paves the way for immunological traffic Jennifer L. Stow p839 | doi:10.1038/nri3564 The 2013 Nobel Prize for Physiology or Medicine recognizes James Rothman, Randy Schekman and Thomas Sudhof, whose work over several decades has characterized key components and mechanisms of the trafficking machinery in eukaryotic cells. Reflecting on these Nobel Prize-winning discoveries raises some important and exciting prospects for immunologists. Full Text | PDF
RESEARCH HIGHLIGHTS Top Antibodies: Taking the sting out p843 | doi:10.1038/nri3568 IgE responses to venom protect animals against potentially lethal subsequent exposures to the venom. PDF T cell responses: A dendritic cell designed for two p844 | doi:10.1038/nri3560 A novel population of CD301b+ dendritic cells potentiates TH2-type immune responses. PDF Natural killer cells: A virtual pick and mix p844 | doi:10.1038/nri3566 Genes and environment contribute to a vast diversity of human NK cell phenotypes. PDF Immunometabolism: Mef2 in sickness and in health p845 | doi:10.1038/nri3563 Phosphorylation of Mef2 controls immune versus metabolic gene expression in infected Drosophila melanogaster. PDF Tumour immunology: Dealing with regulators p846 | doi:10.1038/nri3569 CCR4-specific antibodies deplete regulatory T cells and boost antitumour responses in humans. PDF HIV: Advancing the antibody approach p846 | doi:10.1038/nri3573 Antibodies come to the fore in therapeutic and prophylactic approaches to suppress SHIV in macaques. PDF Infectious disease: Hushing mTOR boosts immunity to pathogens p847 | doi:10.1038/nri3562 Suppression of mTOR signalling can promote immunity to intracellular pathogens. PDF T cells: Adenosine maintains the numbers p848 | doi:10.1038/nri3571 Adenosine regulates thymocyte development and maintains peripheral naive T cells through the regulation of IL-7Rα expression. PDF Immune homeostasis: Balancing the gut p848 | doi:10.1038/nri3577 The histone deacetylase HDAC3 in IECs regulates host-commensal bacteria interactions and maintains intestinal homeostasis. PDF IN BRIEF T cell responses: NFIL3 clocks out TH17 cells | Autoimmunity: Altered microbiota linked to rheumatoid arthritis | Parasite immunity: IL-6 helps the regulators rein in TH2 cells | B cells: The adjuvant action of bisphosphonates | Antibodies: Kupffer cells mediate B cell depletion | Macrophages: BACH2 normal PDF Immunology JOBS of the week Research Associate - Microbiologist (Tarrytown, NY) Regeneron Pharmaceuticals, Inc. Junior Professorship (W1) with Tenure Track in Biological Signalling Research Albert-Ludwigs-University Freiburg Postdoctoral Associate Yale University School of Medicine Group Leader positions The International Center for Infectiology Research (CIRI) Group Leader in Translational Research Institut Curie More Science jobs from Immunology EVENT The Immunology of Ageing 24.02.14 London, UK More science events from
REVIEWS		Top
Studying immunity to zoonotic diseases in the natural host — keeping it real Andrew G. D. Bean, Michelle L. Baker, Cameron R. Stewart, Christopher Cowled, Celine Deffrasnes, Lin-Fa Wang & John W. Lowenthal p851 | doi:10.1038/nri3551 Immunology is traditionally viewed as a science of 'mice and men'. However, key insights can come from the study of immune responses in livestock or wild animals. The fact that the most deadly pathogens of humans are often zoonotic in nature lends further weight to the importance of this research. The authors discuss the benefits of, and challenges posed by, these studies. Abstract | Full Text | PDF | Supplementary information
Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy Richard S. Hotchkiss, Guillaume Monneret & Didier Payen p862 | doi:10.1038/nri3552 Sepsis is the host inflammatory response to severe, life-threatening infection with the presence of organ dysfunction, and is the most frequent cause of mortality in most intensive care units. Here, the authors argue that, following survival of the initial hyper-inflammatory response, the patient enters a protracted immunosuppressive phase and, therefore, that immunotherapies to treat prolonged sepsis must target the specific cellular dysfunctions associated with immunosuppression. Abstract | Full Text | PDF
Age-dependent dysregulation of innate immunity Albert C. Shaw, Daniel R. Goldstein & Ruth R. Montgomery p875 | doi:10.1038/nri3547 Ageing is associated with impaired immune responses to pathogens and vaccines. As described in this Review, ageing results in disrupted regulation of immune cell functions and innate immune receptor signalling, and in the establishment of a persistent pro-inflammatory milieu. The authors explain how this age-associated dysregulation might contribute to chronic inflammatory diseases in the elderly. Abstract | Full Text | PDF
The immunobiology of prion diseases Adriano Aguzzi, Mario Nuvolone & Caihong Zhu p888 | doi:10.1038/nri3553 Prions are infectious proteins that cause fatal neurodegenerative diseases. The prion itself is a misfolded conformer of a normal host protein, which explains why it is difficult for the immune system to respond to it effectively. The authors explain how prions evade, and indeed exploit, immune components to spread to the central nervous system, and they discuss the immunotherapies that are being developed to combat these lethal infections. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Primary lysis of eosinophils as a major mode of activation of eosinophils in human diseased tissues Carl Persson & Lena Uller p902 | doi:10.1038/nri3341-c1 Full Text | PDF
Reply to Eosinophil cytolysis and release of cell-free granules Helene F. Rosenberg & Paul S. Foster p902 | doi:10.1038/nri3341-c2 Full Text | PDF
miR-122, IL28B genotype and the response to interferon in chronic hepatitis C virus infection Jae Il Shin & Michael Eisenhut p902 | doi:10.1038/nri3463-c1 Full Text | PDF
Reply to miR-122, IL28B genotype and the response to interferon in chronic hepatitis C virus infection Markus Heim p902 | doi:10.1038/nri3463-c2 Full Text | PDF
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*2012 Journal Citation Report (Thomson Reuters, 2013)

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