Nature Biotechnology Contents: Volume 31 pp 943 - 1054

Advertisement Discover now Takyon™ qPCR kits for SYBR® and Probes assays.  Emerging from the combination of an optimized reaction buffer and a new efficient enzyme, Takyon™ kits ensure sensitivity and fast delivery of accurate and reproducible results! Takyon™ was inspired by the faster than light particle, "Tachyon". TABLE OF CONTENTS November 2013 Volume 31, Issue 11 Editorial News Bioentrepreneur Opinion and Comment Features News and Views Computational Biology Research Careers and Recruitment Advertisement   Reichert Surface Plasmon Resonance (SPR) systems for biomolecular interaction analysis Investigate protein interactions with other molecules in a real-time and label-free format. Reichert SPR systems generate high-quality kinetic (on/off rates), affinity, thermodynamics and concentration data. Reichert SPR systems are flexible, affordable, and ultra-sensitive.  ReichertSPR.com Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement The Master of Science in Biotechnology at Northeastern University educates students with a core scientific and technological knowledge and equips them with the professional skills necessary for them to rapidly become valued members of the global biopharmaceutical workforce. Online and on-campus learning encourages relationship building and networking between students, faculty, and industry.   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement Just one of many high-quality articles fromFrontiers in Bioengineering and Biotechnology:  A systems engineering perspective on homeostasis and disease (open access) In this article, Ioannis P. Androulakis and colleagues draw analogies between concepts in systems engineering and conceptual models of health and disease; establish connections between these concepts and physiologic modeling; and describe how these mirror onto the physiological counterparts of engineered systems.  Submit your paper today and be a part of the future of research publication.      Editorial Top Receptive to replication   p943 doi:10.1038/nbt.2748 Do replication studies belong in top-tier journals? News Top Drugs with breakthrough status charm investors   pp945 - 947 Melanie Senior doi:10.1038/nbt1113-945 Otsuka snaps up cancer drugmaker Astex   p946 Alli Proffitt doi:10.1038/nbt1113-946 Biosimilars legislation state by state   p947 doi:10.1038/nbt1113-947 Newborns sequenced at NIH   p948 Emma Dorey doi:10.1038/nbt1113-948a First-in-class anemia drug takes aim at Amgen's dominion   pp948 - 949 Aaron Bouchie doi:10.1038/nbt1113-948b Argos attracts unorthodox backers   pp950 Nuala Moran doi:10.1038/nbt1113-950a Monoclonal T-cell receptor drugs pique pharma's interest   pp950 - 951 Cormac Sheridan doi:10.1038/nbt1113-950b UCSD researcher shot by cofounder   p952 Lucas Laursen doi:10.1038/nbt1113-952a Anti-infective monoclonals step in where antimicrobials fail   pp952 - 954 Jeffrey L Fox doi:10.1038/nbt1113-952b GM crop protection act fizzles   p953 Emily Waltz doi:10.1038/nbt1113-953 Around the world in a month   p954 doi:10.1038/nbt1113-954 Data Page 3Q13—IPOs continue to roar   p955 Walter Yang doi:10.1038/nbt.2745 Drug pipeline 3Q13   p956 Laura DeFrancesco doi:10.1038/nbt.2746 News Feature Vaccines for pandemics   pp957 - 960 Charles Schmidt doi:10.1038/nbt.2733 The 2009 H1N1 pandemic showed that the egg-based technology used to produce the bulk of flu vaccine is not nimble enough to protect during a pandemic. Charles Schmidt reports on progress in synthetic and recombinant technologies that may provide an answer. Bioentrepreneur Top Building a business In search of dry powder   pp961 - 964 Jonathan Behr and Phil Murray doi:10.1038/nbt.2729 Opinion and Comment Top Correspondence Lack of detectable oral bioavailability of plant microRNAs after feeding in mice   pp965 - 967 Brent Dickinson, Yuanji Zhang, Jay S Petrick, Gregory Heck, Sergey Ivashuta et al. doi:10.1038/nbt.2737 Reply to Lack of detectable oral bioavailability of plant microRNAs after feeding in mice   pp967 - 969 Xi Chen, Ke Zen and Chen-Yu Zhang doi:10.1038/nbt.2741 Making the biotech IPO work   pp969 - 970 Laura McNamee and Fred Ledley doi:10.1038/nbt.2711 Health technology assessments and innovation   pp970 - 971 Joseph Tucker, Katherine Boone and Paul Fedak doi:10.1038/nbt.2735 The biosimilar price is right   p971 David Gaugh doi:10.1038/nbt.2734 Hearing loss and tinnitus—are funders and industry listening?   pp972 - 974 Christopher R Cederroth, Barbara Canlon and Berthold Langguth doi:10.1038/nbt.2736 Commentary Human genetics as a foundation for innovative drug development   pp975 - 978 Alexander Kamb, Sean Harper and Kari Stefansson doi:10.1038/nbt.2732 New technology has transformed human genetics. It now provides perhaps the single best opportunity to innovate and improve clinical success rates in drug development. Precompetitive consortia in biomedicine—how are we doing?   pp979 - 985 Barbara Mittleman, Garry Neil and Joel Cutcher-Gershenfeld doi:10.1038/nbt.2731 Too few precompetitive consortia are being formed to mitigate lost opportunities and deliver on other potential mutual gains for public and private stakeholders in drug development. Features Top Patents Patents and China's research and development in agricultural biotechnology   pp986 - 988 Ruifa Hu, Xiaobing Wang, Jikun Huang and Jinyang Cai doi:10.1038/nbt.2730 A study assesses Chinese scientists' knowledge of patents and the relationship between scientists' patent-using behaviors and their organizations' mandates. Recent patent applications in biomedical imaging   p989 doi:10.1038/nbt.2752 News and Views Top Next-generation sequencing in the clinic   pp990 - 992 Jason Y Park, Larry J Kricka and Paolo Fortina doi:10.1038/nbt.2743 Pools of cell lines carrying a variety of known mutations are used to validate the performance of a cancer diagnostic test based on next-generation sequencing. See also: Research by Frampton et al. Two views on light sheets   pp992 - 993 Carl G Ebeling and Erik M Jorgensen doi:10.1038/nbt.2739 A dual-view light-sheet microscope combines isotropic spatial resolution with high speed and minimal phototoxicity. See also: Research by Wu et al. Genetically encoded voltage sensor goes live   pp994 - 995 James H Marshel and Karl Deisseroth doi:10.1038/nbt.2738 A genetically encoded voltage indicator enables robust optical recording of membrane voltage changes in the fly brain. Research Highlights   p995 doi:10.1038/nbt.2744 Biotechnology JOBS of the week Biotechnology MSc University of Pecs Professor / Associate Professor in Biotechnology (Synthetic Biology) NTNU (Norwegian University of Science and Technology) Call for Proposal Biotechnology Industry Partnership Programme (BIPP) BIOTECHNOLOGY INDUSTRY RESEARCH ASSISTANCE COUNCIL (BIRAC) Assistant Professor of Biochemistry University of Colorado Boulder Research position on genetic and epigenetic basis of cancer predisposition. Department of Biochemistry University of Lausanne (UNIL) More Science jobs from Biotechnology EVENT 3rd Biotechnology World Congress February 10, 2014 Dubai More science events from Computational Biology Top Commentary So you want to be a computational biologist?   pp996 - 998 Nick Loman and Mick Watson doi:10.1038/nbt.2740 Two computational biologists give advice when starting out on computational projects. Research Top Review Reassessing target antigens for adoptive T-cell therapy   pp999 - 1008 Christian S Hinrichs and Nicholas P Restifo doi:10.1038/nbt.2725 Articles A single-molecule long-read survey of the human transcriptome   pp1009 - 1014 Donald Sharon, Hagen Tilgner, Fabian Grubert and Michael Snyder doi:10.1038/nbt.2705 Sequencing the human transcriptome using long, single-molecule reads identifies new transcript isoforms. Reproducibility of high-throughput mRNA and small RNA sequencing across laboratories   pp1015 - 1022 Peter A C 't Hoen, Marc R Friedlander, Jonas Almlof, Michael Sammeth, Irina Pulyakhina et al. doi:10.1038/nbt.2702 RNA sequencing of 465 human lymphoblastoid cell lines across seven European laboratories shows the feasibility of transcriptome sequencing for population-wide and cross-biobank studies. Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing   pp1023 - 1031 Garrett M Frampton, Alex Fichtenholtz, Geoff A Otto, Kai Wang, Sean R Downing et al. doi:10.1038/nbt.2696 Clinical tests that rely on next-generation sequencing to evaluate large numbers of cancer genes can be validated using pooled cell lines with known mutations. See also: News and Views by Park et al. Spatially isotropic four-dimensional imaging with dual-view plane illumination microscopy   pp1032 - 1038 Yicong Wu, Peter Wawrzusin, Justin Senseney, Robert S Fischer, Ryan Christensen et al. doi:10.1038/nbt.2713 A dual-view light sheet microscope allows high-speed imaging with an isotropic spatial resolution See also: News and Views by Ebeling & Jorgensen Engineering dynamic pathway regulation using stress-response promoters   pp1039 - 1046 Robert H Dahl, Fuzhong Zhang, Jorge Alonso-Gutierrez, Edward Baidoo, Tanveer S Batth et al. doi:10.1038/nbt.2689 The problem of toxic intermediates in engineered metabolic pathways is mitigated by dynamic gene-expression regulation using stress-responsive promoters. Strategic addition of an N-linked glycan to a monoclonal antibody improves its HIV-1-neutralizing activity   pp1047 - 1052 Ruijiang Song, Deena A Oren, David Franco, Michael S Seaman and David D Ho doi:10.1038/nbt.2677 Strategic insertion of an N-linked glycan into the variable domain of an antibody improves its ability to inhibit HIV-1 infection. Careers and Recruitment Top Third-quarter biotech job picture   p1053 Michael Francisco doi:10.1038/nbt.2742 People People   p1054 doi:10.1038/nbt.2750 Advertisement nature.com webcasts Macmillan Science Communication presents a custom webcast on: The latest innovations in real-time imaging of cells with Super Resolution Microscopy Thursday November 7th at 8am PST / 11am EST / 4pm GMT / 5pm CET  Register for the free webcast followed by our live Q & A session  Sponsored by:     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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