Molecular Systems Biology - New articles published 12 November 2013

Advertisement Enable Your Omics Research Find the critical information in your sample through proteomics, metabolomics or systems biology with Agilent LC/MS and GC/MS systems. Together with powerful statistical analysis and pathway visualization software, Agilent provides one single, consistent user interface that transforms data into deeper biological understanding. Learn more about the Agilent Integrated Biology solutions. Latest Articles 12th November 2013   Featured Article Research Articles News and Views   Web feeds About Open access Advertisement Advances in Molecular Medicine - EMBO Editors' Choice  This web focus, which features content from the four EMBO scientific publications, includes recent research and review articles that exemplify a wide range of perspectives on molecular medicine research.      Featured Article Promoter decoding of transcription factor dynamics involves a trade-off between noise and control of gene expression The relationship between the dynamics of transcription factor activity, differential gene expression and noise in gene expression is analyzed in yeast to understand how different genetic programs can be activated by controlling the dynamics of a single transcription factor. Anders S Hansen & Erin K O’Shea Molecular Systems Biology 9:704; doi:10.1038/msb.2013.56; published 5 November 2013 Full Text | PDF | Supp. Inf. | Review Process Research Articles Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms A ‘lung cancer’-specific mutant EGFR interactome was generated by a global analysis of protein–protein interactions and phosphorylation. After functional screening, nine proteins were identified as essential for the viability of EGFR-mutant lung cancer cells. Jiannong Li, Keiryn Bennett, Alexey Stukalov, Bin Fang, Guolin Zhang, Takeshi Yoshida, Isamu Okamoto, Jae-Young Kim, Lanxi Song, Yun Bai, Xiaoning Qian, Bhupendra Rawal, Michael Schell, Florian Grebien, Georg Winter, Uwe Rix, Steven Eschrich, Jacques Colinge, John Koomen, Giulio Superti-Furga & Eric B Haura Molecular Systems Biology 9:705; doi:10.1038/msb.2013.61; published 5 November 2013 Full Text | PDF | Supp. Inf. | Review Process A pharmaco-epistasis strategy reveals a new cell size controlling pathway in yeast Pharmaco-epistasis analyses using drugs mimicking cell size mutations in yeast uncovered a novel pathway in cell size homeostasis regulation. This pathway involves the sirtuin Sir2, the large ribosomal subunit (60S) and the Swi4/Swi6 transcription factors. Fabien Moretto, Isabelle Sagot, Bertrand Daignan-Fornier & Benoît Pinson Molecular Systems Biology 9:707; doi:10.1038/msb.2013.60; published 12 November 2013 Full Text | PDF | Supp. Inf. | Review Process News and Views Promoter decoding of transcription factor dynamics Amie D Moody & Eric Batchelor Molecular Systems Biology 9:703; doi:10.1038/msb.2013.63; published 5 November 2013 Full Text | PDF Cell size control is sirtuin(ly) exciting Jill Wright & Brandt L Schneider Molecular Systems Biology 9:706; doi:10.1038/msb.2013.64; published 12 November 2013 Full Text | PDF     You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.