EMBO Reports - Table of Contents alert Volume 14 Issue 12, pp 1023-1148

TABLE OF CONTENTS December 2013 | Volume 14, Issue 12 Upfront Science & Society Reviews Scientific Reports Also new AOP Recommend to your library Advertisement EMBO Press launches in December, uniting the policies and initiatives of EMBO reports, The EMBO Journal, EMBO Molecular Medicine and Molecular Systems Biology. Our vision is to make science publishing more transparent, and to transform articles into data-enriched, accessible records of research. The journals continue to select important work from the global life sciences community for publication.    Upfront Top Editorial Science is the drug … in which Howy confesses to some eccentric proclivities. Howy Jacobs EMBO reports (2013), 14, 1023; 10.1038/embor.2013.153 Full text | PDF Published online: 29 November 2013 Subject Categories: Health & Disease | Societal Issues & Politics Three sides of a coin The ‘Drugs & Science’ series in EMBO reports will highlight the therapeutic, the risky and the societal aspects of drug use and abuse. Holger Breithaupt EMBO reports (2013), 14, 1024; 10.1038/embor.2013.184 Full text | PDF Published online: 29 November 2013 Subject Categories: Health & Disease | Societal Issues & Politics Opinion Thirteen follies and fallacies about alternative medicine Thirteen common misunderstandings about alternative medicine and the consequences for health. Edzard Ernst EMBO reports (2013), 14, 1025 - 1026; 10.1038/embor.2013.174 Full text | PDF Published online: 01 November 2013 Subject Categories: Health & Disease | Societal Issues & Politics Correspondence Comment on the Howy Jacobs' Editorial “Yes we can, but do we?” Abraham L Sonenshein EMBO reports (2013), 14, 1027; 10.1038/embor.2013.176 Full text | PDF Published online: 08 November 2013 Subject Categories: Science Policy & Funding Hot off the Press MxB/Mx2: the latest piece in HIV's interferon puzzle Three groups have recently shown in Nature and Cell Host & Microbe that MxB/Mx2 is an interferon-inducible HIV restriction factor, adding to the innate arsenal of the cell against the virus and paving the way for the possible development of new antiviral strategies. Oliver T Fackler and Oliver T Keppler EMBO reports (2013), 14, 1028 - 1029; 10.1038/embor.2013.172 Full text | PDF Published online: 01 November 2013 Subject Categories: Microbiology & Pathogens Remodelling without a power stroke Although chromatin remodellers are thought to exert power strokes to move nucleosomes along DNA, two studies in this issue show that a power stroke is not required for efficient remodelling, indicating that the DNA binding domain primarily tethers remodellers to nucleosomes. Arnob Dutta and Jerry L Workman EMBO reports (2013), 14, 1030 - 1031; 10.1038/embor.2013.166 Full text | PDF Published online: 25 October 2013 Subject Categories: Chromatin & Transcription Human Primpol1: a novel guardian of stalled replication forks Huang and colleagues identify a human primase-polymerase that is required for stalled replication fork restart and the maintenance of genome integrity. Jun-Sub Im, Kyung Yong Lee, Laura W Dillon and Anindya Dutta EMBO reports (2013), 14, 1032 - 1033; 10.1038/embor.2013.171 Full text | PDF Published online: 05 November 2013 Subject Categories: Genome Stability & Dynamics Science & Society Top From promise to practice Synthetic biology has the potential to profoundly change the way we produce many chemicals, as well as to reduce the environmental impact of the chemical industry. David R Nielsen and Tae Seok Moon EMBO reports (2013), 14, 1034 - 1038; 10.1038/embor.2013.178 Full text | PDF Published online: 08 November 2013 Subject Categories: Technology, Development & Applications Complex diseases require complex therapies Understanding disease causes and drug action at the molecular and systems levels could help to identify combinations of drugs that are more effective than individual drugs alone. Ravi Iyengar EMBO reports (2013), 14, 1039 - 1042; 10.1038/embor.2013.177 Full text | PDF Published online: 15 November 2013 Subject Categories: Health & Disease | Technology, Development & Applications Tapping the crowds for research funding Scientists are exploring crowdfunding as a potential new source of cash for their research. Katrin Weigmann EMBO reports (2013), 14, 1043 - 1046; 10.1038/embor.2013.180 Full text | PDF Published online: 08 November 2013 Subject Categories: Science Policy & Funding EU-LIFE revives funding debate EU-LIFE, which represents 10 European life science research institutes, has reopened the debate about how to fund research at the European level by calling for the budget of the European Research Council to be drastically increased. Philip Hunter EMBO reports (2013), 14, 1047 - 1049; 10.1038/embor.2013.183 Full text | PDF Published online: 15 November 2013 Subject Categories: Science Policy & Funding Reviews Top Building and remodelling Cullin–RING E3 ubiquitin ligases Cullin-RING E3 ubiquitin ligases (CRLs) are multiprotein complexes that ubiquitylate a plethora of signalling proteins, thereby broadly affecting cellular processes. This review is focused on how CRLs are dynamically controlled, with an emphasis on neddylation cycles and substrate receptor exchange. John R Lydeard, Brenda A Schulman and J Wade Harper EMBO reports (2013), 14, 1050 - 1061; 10.1038/embor.2013.173 Abstract | Full text | PDF Published online: 15 November 2013 Subject Categories: Signal Transduction | Proteins Cellular dynamics in the muscle satellite cell niche Multiple, functionally diverse cell types have been shown to contribute to skeletal muscle regeneration. This Review discusses the cellular dynamics and the roles of immune, fibrogenic, vessel-associated and myogenic cells in the response of the satellite cell niche to muscle injury and disease. C Florian Bentzinger, Yu Xin Wang, Nicolas A Dumont and Michael A Rudnicki EMBO reports (2013), 14, 1062 - 1072; 10.1038/embor.2013.182 Abstract | Full text | PDF Published online: 15 November 2013 Subject Categories: Molecular Biology of Disease | Development Three wise centromere functions: see no error, hear no break, speak no delay  EMBO Open Centromeres are known to promote kinetochore assembly. However, two other roles—facilitating robust sister chromatid cohesion and advancing the replication timing of centromeric regions—have recently emerged. The three are analysed in this Review. Tomoyuki U Tanaka, Lesley Clayton and Toyoaki Natsume EMBO reports (2013), 14, 1073 - 1083; 10.1038/embor.2013.181 Abstract | Full text | PDF Published online: 15 November 2013 Subject Categories: Cell Cycle Scientific Reports Top PARP1 orchestrates variant histone exchange in signal-mediated transcriptional activation  EMBO Open This study reveals an essential role for PARP1 in the exchange of the histone variant H2A.Z by H2A at the -1 nucleosome of the FOS promoter, which promotes signal-induced transcriptional activation. Amanda O'Donnell, Shen-Hsi Yang and Andrew D Sharrocks EMBO reports (2013), 14, 1084 - 1091; 10.1038/embor.2013.164 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 22 October 2013 Subject Categories: Chromatin & Transcription No need for a power stroke in ISWI-mediated nucleosome sliding Nucleosome remodellers are thought to mechanically pull extranucleosomal DNA into the nucleosome. Surprisingly, even when the mechanical step is experimentally prevented, ISWI can still reposition nucleosomes. The authors discuss alternative models to explain the mechanism. Johanna Ludwigsen, Henrike Klinker and Felix Mueller-Planitz EMBO reports (2013), 14, 1092 - 1097; 10.1038/embor.2013.160 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 11 October 2013 Subject Categories: Chromatin & Transcription | Proteins Nucleosome sliding by Chd1 does not require rigid coupling between DNA-binding and ATPase domains Chromatin remodellers are thought to require a rigid connection between ATPase and DNA-binding domain to reposition nucleosomes. However, the linking segment of Chd1 can accommodate large changes in length and flexibility, showing that current models for remodeller activity must be revised. Ilana M Nodelman and Gregory D Bowman EMBO reports (2013), 14, 1098 - 1103; 10.1038/embor.2013.158 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 15 October 2013 Subject Categories: Chromatin & Transcription hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity This study identifies the first human DNA primase-polymerase, which is required for stalled replication fork restart and the maintenance of genome integrity. Li Wan, Jiangman Lou, Yisui Xia, Bei Su, Ting Liu, Jiamin Cui, Yingying Sun, Huiqiang Lou and Jun Huang EMBO reports (2013), 14, 1104 - 1112; 10.1038/embor.2013.159 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 15 October 2013 Tpo1-mediated spermine and spermidine export controls cell cycle delay and times antioxidant protein expression during the oxidative stress response  EMBO Open Cellular export of the metabolites spermine and spermidine is induced under oxidative stress to control the timing of antioxidant gene expression and cell cycle delay and to promote cell survival. Antje Krüger, Jakob Vowinckel, Michael Mülleder, Phillip Grote, Floriana Capuano, Katharina Bluemlein and Markus Ralser EMBO reports (2013), 14, 1113 - 1119; 10.1038/embor.2013.165 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 18 October 2013 Subject Categories: Cellular Metabolism | Proteins Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin This study shows that both ZNRF3- and LGR4-binding motifs of R-spondin are required for its Wnt-promoting activity. These results support a dual receptor model of R-spondin signalling, where LGR4 serves as the engagement receptor while ZNRF3 functions as the effector receptor. Yang Xie, Raffaella Zamponi, Olga Charlat, Melissa Ramones, Susanne Swalley, Xiaomo Jiang, Daniel Rivera, William Tschantz, Bo Lu, Lisa Quinn, Chris Dimitri, Jefferson Parker, Doug Jeffery, Sheri K Wilcox, Mike Watrobka, Peter LeMotte, Brian Granda, Jeffrey A Porter, Vic E Myer, Andreas Loew and Feng Cong EMBO reports (2013), 14, 1120 - 1126; 10.1038/embor.2013.167 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 29 October 2013 Subject Categories: Signal Transduction Loss of iron triggers PINK1/Parkin-independent mitophagy  EMBO Open A novel mitophagy assay uncovers a new PINK1/Parkin-independent mitophagy pathway induced by a decrease in iron levels. This pathway is active in fibroblasts of Parkinson patients with Parkin mutations and could be exploited as a potential therapy. George F G Allen, Rachel Toth, John James and Ian G Ganley EMBO reports (2013), 14, 1127 - 1135; 10.1038/embor.2013.168 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 01 November 2013 Subject Categories: Molecular Biology of Disease | Cellular Metabolism Tightly controlled WRKY23 expression mediates Arabidopsis embryo development This study presents evidence that the tightly controlled expression of the transcription factor WRKY23 regulates both auxin-dependent and auxin-independent signalling pathways leading to root stem cell niche specification in Arabidopsis. Wim Grunewald, Ive De Smet, Bert De Rybel, Helene S Robert, Brigitte van de Cotte, Viola Willemsen, Godelieve Gheysen, Dolf Weijers, Jiří Friml and Tom Beeckman EMBO reports (2013), 14, 1136 - 1142; 10.1038/embor.2013.169 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 25 October 2013 Subject Categories: Signal Transduction | Plant Biology | Development Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells This study provides evidence that the activity of renal non-selective stretch-activated ion channels (SACs) depends on Piezo1 but is negatively regulated by Polycystin-2 (PC2). PC2 co-immunoprecipitates with Piezo1 and deletion of its N-terminal domain prevents both this interaction and inhibition of SAC activity. Rémi Peyronnet, Joana R Martins, Fabrice Duprat, Sophie Demolombe, Malika Arhatte, Martine Jodar, Michel Tauc, Christophe Duranton, Marc Paulais, Jacques Teulon, Eric Honoré and Amanda Patel EMBO reports (2013), 14, 1143 - 1148; 10.1038/embor.2013.170 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 25 October 2013 Subject Categories: Signal Transduction Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to EMBO reports. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. 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