Wednesday, October 16, 2013

The EMBO Journal - Table of Contents alert Volume 32 Issue 20

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TABLE OF CONTENTS

16 October 2013 | Volume 32, Issue 20

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Editor's Choice - Transcription factors, lincRNAs and differentiation 

The Yin and Yang of enhancer-like RNAs
Ramin Shiekhattar  

Genome-wide survey by ChIP-seq reveals YY1 regulation of lincRNAs in skeletal myogenesis
Leina Lu, Huating Wang and colleagues 

Have you seen?

Top

Lncing protein translation to metastasis

An oncogenic lncRNP complex controls E-cadherin translation and highlights the importance of post-transcriptional regulation in metastasis formation.

Fabricio Loayza-Puch and Reuven Agami

The EMBO Journal (2013), 32, 2657 - 2658; 10.1038/emboj.2013.210

Abstract | Full text | PDF | Related article

Published online: 24 September 2013

Autophagy plays a WASHing game

In addition to regulating endosomal sorting, WASH represses starvation-induced autophagy by interfering with Beclin 1 ubiquitylation.

Nicolas Dupont and Patrice Codogno

The EMBO Journal (2013), 32, 2659 - 2660; 10.1038/emboj.2013.202

Abstract | Full text | PDF | Related article

Published online: 06 September 2013

Review

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How unfinished business from S-phase affects mitosis and beyond

Hickson and colleagues review emerging concepts on how replication problems are frequently processed only in subsequent cell-cycle stages, and postulate that cells may even exploit this to ensure genome stability maintenance during cell division.

Hocine W Mankouri, Diana Huttner and Ian D Hickson

The EMBO Journal (2013), 32, 2661 - 2671; 10.1038/emboj.2013.211

Abstract | Full text | PDF

Published online: 24 September 2013

Articles

Top

Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step

Cancer-associated suppression of E-cadherin expression by treRNA exemplifies a novel mechanism of translational regulation by long non-coding RNAs.

Kiranmai Gumireddy, Anping Li, Jinchun Yan, Tetsuro Setoyama, Gregg J Johannes, Ulf A Ørom, Julia Tchou, Qin Liu, Lin Zhang, David W Speicher, George A Calin and Qihong Huang

The EMBO Journal (2013), 32, 2672 - 2684; 10.1038/emboj.2013.188

Abstract | Full text | PDF | Supp. info. | Review Process File

Published online: 23 August 2013

WASH inhibits autophagy through suppression of Beclin 1 ubiquitination

WASH, a regulator of endosomal fission via activation of Arp2/3, is shown for the first time to inhibit autophagy during embryonic development by suppression of lysine 437 ubiquitination of Beclin 1.

Pengyan Xia, Shuo Wang, Ying Du, Zhenao Zhao, Lei Shi, Lei Sun, Guanling Huang, Buqing Ye, Chong Li, Zhonghua Dai, Ning Hou, Xuan Cheng, Qingyuan Sun, Lei Li, Xiao Yang and Zusen Fan

The EMBO Journal (2013), 32, 2685 - 2696; 10.1038/emboj.2013.189

Abstract | Full text | PDF | Supp. info. | Review Process File

Published online: 23 August 2013

Blm10 facilitates nuclear import of proteasome core particles

A HEAT repeat-containing proteasome activator serves a Ran-GTP-regulated karyopherin role for cytoplasmically sequestered 20S proteasome core particles.

Marion H Weberruss, Anca F Savulescu, Julia Jando, Thomas Bissinger, Amnon Harel, Michael H Glickman and Cordula Enenkel

The EMBO Journal (2013), 32, 2697 - 2707; 10.1038/emboj.2013.192

Abstract | Full text | PDF | Supp. info. | Review Process File

Published online: 27 August 2013

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis  EMBO Open

The establishment of conditions for long-term culture and expansion of adult, bi-potent pancreas progenitors may facilitate novel and tailored therapeutic approaches.

Meritxell Huch, Paola Bonfanti, Sylvia F Boj, Toshiro Sato, Cindy J M Loomans, Marc van de Wetering, Mozhdeh Sojoodi, Vivian S W Li, Jurian Schuijers, Ana Gracanin, Femke Ringnalda, Harry Begthel, Karien Hamer, Joyce Mulder, Johan H van Es, Eelco de Koning, Robert G J Vries, Harry Heimberg and Hans Clevers

The EMBO Journal (2013), 32, 2708 - 2721; 10.1038/emboj.2013.204

Abstract | Full text | PDF | Supp. info. | Review Process File

Published online: 17 September 2013

Endophilin, Lamellipodin, and Mena cooperate to regulate F-actin-dependent EGF-receptor endocytosis  EMBO Open

Cooperation between a BAR domain protein and a regulator of actin filament elongation during lamellipodia protrusion reveals actin cytoskeleton roles in endocytic vesicle scission in mammalian cells.

Anne Vehlow, Daniel Soong, Gema Vizcay-Barrena, Cristian Bodo, Ah-Lai Law, Upamali Perera and Matthias Krause

The EMBO Journal (2013), 32, 2722 - 2734; 10.1038/emboj.2013.212

Abstract | Full text | PDF | Supp. info. | Review Process File

Published online: 27 September 2013

CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP

The mechanisms underlying filopodia initiation and localization at the plasma membrane are only incompletely understood. This study presents a new model in which active Cdc42 promotes IRSp53-dependent VASP localization at discrete foci, where it drives actin polymerization and initiates filopodia formation.

Andrea Disanza, Sara Bisi, Moritz Winterhoff, Francesca Milanesi, Dmitry S Ushakov, David Kast, Paola Marighetti, Guillaume Romet-Lemonne, Hans-Michael Müller, Walter Nickel, Joern Linkner, Davy Waterschoot, Christophe Ampè, Salvatore Cortellino, Andrea Palamidessi, Roberto Dominguez, Marie-France Carlier, Jan Faix and Giorgio Scita

The EMBO Journal (2013), 32, 2735 - 2750; 10.1038/emboj.2013.208

Abstract | Full text | PDF | Supp. info. | Review Process File

Published online: 27 September 2013

IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage  EMBO Open

IFNβ induces the formation of a novel transcriptional complex, U-ISGF3, which contains un-phosphorylated STATs. U-ISGF3 regulates the expression of a subset of IFNβ-stimulated genes to promote resistance to virus infection and DNA damage.

HyeonJoo Cheon, Elise G Holvey-Bates, John W Schoggins, Samuel Forster, Paul Hertzog, Naoko Imanaka, Charles M Rice, Mark W Jackson, Damian J Junk and George R Stark

The EMBO Journal (2013), 32, 2751 - 2763; 10.1038/emboj.2013.203

Abstract | Full text | PDF | Supp. info. | Review Process File

Published online: 24 September 2013

Antagonistic functions between the RNA chaperone Hfq and an sRNA regulate sensitivity to the antibiotic colicin

While most bacterial sRNAs act in complex with the RNA chaperone Hfq, the sRNA RyhB relieves repressive Hfq binding to the cirA mRNA. Since CirA is the receptor for colicin, RyhB raises sensitivity to the antibiotic.

Hubert Salvail, Marie-Pier Caron, Justine Bélanger and Eric Massé

The EMBO Journal (2013), 32, 2764 - 2778; 10.1038/emboj.2013.205

Abstract | Full text | PDF | Supp. info. | Review Process File

Published online: 24 September 2013

Corrigendum

Top

A cyclic GMP-dependent signalling pathway regulates bacterial phytopathogenesis

Shi-Qi An, Ko-Hsin Chin, Melanie Febrer, Yvonne McCarthy, Jauo-Guey Yang, Chung-Liang Liu, David Swarbreck, Jane Rogers, J Maxwell Dow, Shan-Ho Chou and Robert P Ryan

The EMBO Journal (2013), 32, 2779 - 2781; 10.1038/emboj.2013.215

Full text | PDF | Supp. info.

Published online: 20 September 2013

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