Nature Reviews Immunology Contents November 2013 Volume 13 Number 11 pp 771-838

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TABLE OF CONTENTS
November 2013 Volume 13 Number 11		Advertisement
Impact Factor 33.129 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Microbiota-mediated colonization resistance against intestinal pathogens Charlie G. Buffie & Eric G. Pamer	Just one of many high-quality articles from Frontiers in Immunology: Use it or lose it: establishment and persistence of T cell memory (open access) In this review article, Katherine Kedzierska and colleagues discuss the mechanisms underlying the early establishment of immunological memory and the subsequent persistence of memory T cell pools in animal models and humans. Be a part of the future of research publication
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RESEARCH HIGHLIGHTS Top Immunogenetics: SNPing at FOXO3 to limit inflammation p771 | doi:10.1038/nri3548 A FOXO3-dependent pathway that limits inflammation is associated with disease prognosis in humans. PDF Inflammasomes: When LPS sneaks into the cell p772 | doi:10.1038/nri3546 Intracellular LPS triggers non-canonical inflammasome activation of caspase 11. PDF Haematopoiesis: Two versions of the Ikaros tale p772 | doi:10.1038/nri3550 Zinc fingers 1 and 4 of the Ikaros protein have differential roles in lymphocyte development and in lymphomagenesis. PDF Antibodies: Want to neutralize HIV? Get help! p773 | doi:10.1038/nri3554 The presence of memory TFH cells in the blood correlates with the development of broadly neutralizing antibodies against HIV. PDF Immunometabolism: Keeping eosinophils on time — ILC2 it! p774 | doi:10.1038/nri3549 Type 2 ILCs respond to metabolic cues and tune eosinophil numbers to the circadian clock. PDF Immunotherapy: Cancer immunotherapy for the elderly p774 | doi:10.1038/nri3557 Ageing predisposes individuals to macrophage- and TNF-dependent intolerance of cancer immunotherapy. PDF Tolerance: The dual mucus defence p774 | doi:10.1038/nri3558 Binding of the mucus component mucin 2 to intestinal dendritic cells delivers immunoregulatory signals. PDF IN BRIEF Macrophages: Interleukin-4 boosts macrophage numbers | Mucosal immunology: Linking ER stress, autophagy and colitis | Macrophages: The shape of things to come PDF Immunology JOBS of the week Sr. Research Associate VGTI Florida Post Doctoral Research Fellow in Immunotherapy Washington University School of Medicine Faculty Positions The Hong Kong University of Science and Technology Postdoctoral Fellow University of Massachusett Medical School Assistant Professor Brock University More Science jobs from Immunology EVENT Malaria Immunology and Vaccination 02.07.14 London, UK More science events from
REVIEWS		Top
T-bet: a bridge between innate and adaptive immunity Vanja Lazarevic, Laurie H. Glimcher & Graham M. Lord p777 | doi:10.1038/nri3536 The transcription factor T-bet is best known to immunologists as a master regulator of T helper 1 cell differentiation. However, it is becoming apparent that T-bet has important functions in other leukocyte populations, including memory CD8+ T cells, B cells, innate lymphoid cells, dendritic cells and natural killer cells. This Review discusses these emerging immunological roles for T-bet. Abstract | Full Text | PDF
Microbiota-mediated colonization resistance against intestinal pathogens Charlie G. Buffie & Eric G. Pamer p790 | doi:10.1038/nri3535 Colonization resistance — protection from exogenous pathogens by commensal bacteria — can be mediated by direct antagonism and by indirect effects on the host immune response. This Review outlines our current knowledge of immune-mediated colonization resistance against clinically relevant, antibiotic-resistant intestinal pathogens and how insights into commensal bacterial species and their mechanisms might be therapeutically used to restore resistance. Abstract | Full Text | PDF
Immunological functions of the neuropilins and plexins as receptors for semaphorins Atsushi Kumanogoh & Hitoshi Kikutani p802 | doi:10.1038/nri3545 Semaphorins and their primary receptors, the neuropilins and plexins, participate in a wide range of innate and adaptive immune responses, which has implications for immune disorders such as multiple sclerosis, rheumatoid arthritis and allergy. Abstract | Full Text | PDF
Immune regulation by atypical chemokine receptors Robert J. B. Nibbs & Gerard J. Graham p815 | doi:10.1038/nri3544 Chemokines control key immunological processes by signalling through G protein-coupled receptors. In addition, chemokines can be bound by atypical chemokine receptors (ACKRs), which are structurally related to conventional chemokine receptors, but which do not mediate classical signalling responses. This Review describes the biological functions of ACKRs and introduces the new nomenclature that has been proposed for this family. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Thymus involution and regeneration: two sides of the same coin? Thomas Boehm & Jeremy B. Swann p831 | doi:10.1038/nri3534 The age-related involution of the thymus is associated with impaired cellular immunity and it is possible that restoring the thymopoietic activity of the thymus could have medical benefits. In this Opinion article, the authors discuss the development, involution and regeneration of the thymus and highlight the major gaps that still remain in our understanding of these processes. Abstract | Full Text | PDF
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Nature Immunology  FOCUS ON TISSUE-RESIDENT LEUKOCYTES Tissue-resident immune cells communicate with resident stromal cells to patrol and monitor against infection and tissue damage. Nature Immunology presents five specially commissioned Reviews that discuss interactions and functions of tissue-resident leukocytes within nonlymphoid tissues during healthy steady state, upon infection and within tumor environments.
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*2012 Journal Citation Report (Thomson Reuters, 2013)

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