Nature Reviews Genetics Contents November 2013 Volume 14 Number 11 pp 745-820

TABLE OF CONTENTS
November 2013 Volume 14 Number 11		Advertisement
Impact Factor 41.063 *	In this issue Research Highlights Reviews Also this month Article series: Disease mechanisms  Featured article: Advanced genetic tools for plant biotechnology Wusheng Liu, Joshua S. Yuan & C. Neal Stewart Jr	Are you attending ASHG? Register for IPA and Variant Analysis workshops at www.ingenuity.com/ashg2013. Visit the Ingenuity Booth #621 Ingenuity IPA Workshop: Wed October 23, 12:30 - 2:00pm, room 051 Ingenuity Variant Analysis Workshop: Thurs October 24, 12:30 - 2:00pm, room 051
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RESEARCH HIGHLIGHTS Top Development: Germ cell poising for totipotency p745 | doi:10.1038/nrg3596 PDF Complex traits: Adding complexity to yeast p746 | doi:10.1038/nrg3598 PDF Disease genetics: A Mendelian code for complex disease p746 | doi:10.1038/nrg3599 PDF Evolution: Speciation goes with the flow p748 | doi:10.1038/nrg3597 PDF Small RNAs: RNAs attack! p748 | doi:10.1038/nrg3600 PDF Gene regulation: Chromatin editing reveals enhancer targets p749 | doi:10.1038/nrg3601 PDF Cancer genomics: A panoramic view of cancer p750 | doi:10.1038/nrg3602 PDF IN BRIEF Plant genetics: Tunable plastic development | Complex disease: A SNP for disease prognosis | Evolution: Interference follows duplication | Circadian biology: MicroRNAs needed for time delay | Ageing: Re-evaluating oxidative damage in ageing | Epigenetics: Transgenerational effects of folate defects | Evolution: Resolving Darwin's dilemma | DNA damage: H3.3 recovers transcription PDF Genetics JOBS of the week Assistant Professor in Human Genetics UT Southwestern Medical Center Chair, Genetics & Medical Genetics University of Wisconsin - Madison Faculty Positions in Cancer Biology / Genetics OMRF Investigator Scientist (Research Scientist) (Fixed Term) University of Cambridge Postdoctoral fellow The Hebrew University of Jerusalem More Science jobs from Genetics EVENT 3d International Conference on Genetics of Aging and Longevity 10.04.14 Sochi, Russia More science events from
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REVIEWS		Top
The genetic causes of convergent evolution David L. Stern p751 | doi:10.1038/nrg3483 This Review distinguishes between three distinct routes by which similar genetic changes contribute to convergent evolution and discusses examples from diverse taxa. Convergent genetic evolution might result from the fact that some mutations both minimize pleiotropic effects and maximize adaptation. Abstract | Full Text | PDF
Article series: Disease mechanisms Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer Christoph Plass, Stefan M. Pfister, Anders M. Lindroth, Olga Bogatyrova, Rainer Claus & Peter Lichter p765 | doi:10.1038/nrg3554 There is an increasing realization of epigenetic dysregulation in cancer, which comprises both the mutation of genes encoding epigenetic regulators and the broader disruptions to chromatin states of the epigenome. This Review discusses our latest understanding of these phenomena, their convergence and the implications for cancer biology and therapeutics. Abstract | Full Text | PDF
Advanced genetic tools for plant biotechnology Wusheng Liu, Joshua S. Yuan & C. Neal Stewart Jr p781 | doi:10.1038/nrg3583 New tools for plant biotechnology are emerging, including synthetic promoters, 'tunable' transcription factors, genome-editing tools and site-specific recombinases. These tools promise to expand the range of plant biotechnology applications, especially when integrated with approaches for manipulating large DNA constructs. Abstract | Full Text | PDF | Supplementary information
Meiotic recombination in mammals: localization and regulation Frédéric Baudat, Yukiko Imai & Bernard de Massy p794 | doi:10.1038/nrg3573 Genetic exchanges between homologous chromosomes are essential for producing haploid gametes and increase genetic diversity. Recent advances have provided insights into the mechanisms that specify recombination hot spots and the regulation of the exchange of genetic material between mammalian chromosomes. Abstract | Full Text | PDF
Ecological genomics of local adaptation Outi Savolainen, Martin Lascoux & Juha Merilä p807 | doi:10.1038/nrg3522 Populations of many species show phenotypic adaptations in order to maximize their fitness in local environments. This Review describes various strategies for characterizing the genomic underpinnings of these adaptations and the key findings that are emerging. Abstract | Full Text | PDF
Erratum: Transgenerational epigenetic inheritance: how important is it? Ueli Grossniklaus, William G. Kelly, Anne C. Ferguson-Smith, Marcus Pembrey & Susan Lindquist p820 | doi:10.1038/nrg3595 Full Text | PDF
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