Nature Review Cancer contents November 2013 Volume 13 Number 11 pp 753-820

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TABLE OF CONTENTS
November 2013 Volume 13 Number 11
Impact Factor 35 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Inflammation–induced cancer: crosstalk between tumours, immune cells and microorganisms Eran Elinav, Roni Nowarski, Christoph A. Thaiss, Bo Hu, Chengcheng Jin & Richard A. Flavell
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RESEARCH HIGHLIGHTS Top Tumour microenvironment: Teaching old macrophages new tricks p753 | doi:10.1038/nrc3616 Inhibition of macrophage colony-stimulating factor 1 receptor (CSF1R) can block glioblastoma growth by changing the phenotype of tumour-associated macrophages from pro-tumorigenic to antitumorigenic. PDF Prostate cancer: Understanding why p754 | doi:10.1038/nrc3615 Two papers published in Cancer Discovery unveil the molecular mechanisms that underpin the improved response of patients with high-risk prostate cancer to ionizing radiation in the presence of androgen deprivation therapy. PDF IN THE NEWS To have and to hold p754 | doi:10.1038/nrc3620 A recent study published in the Journal of Clinical Oncology has indicated that married cancer patients fare better than singletons. PDF Cancer genomics: A panoramic view of cancer p755 | doi:10.1038/nrc3617 A coordinately published set of papers in Nature, Nature Genetics and other journals report data from up to 5,000 individual cancers, including cancers of the breast, uterus, ovaries, lung, brain, head and neck, colon and rectum, bladder, kidney and blood. PDF Tumour microenvironment: To me, to you p756 | doi:10.1038/nrc3618 Powers and colleagues characterize tumour-promoting fibroblast-basal breast cancer cell crosstalk. PDF Metabolism: IDH2 drives cancer in vivo p756 | doi:10.1038/nrc3619 Mutations in the metabolic gene isocitrate dehydrogenase 2 (IDH2) drive the development of leukaemia and sarcoma in vivo. PDF IN BRIEF Tumour microenvironment: Tissue-specific functions | Therapeutic resistance: Blocking a mutant | Tumour microenvironment: Time to decompress | Tumorigenesis: Loss of polarity PDF Cancer JOBS of the week Postdoc Position – Cancer Drug Resistance Brigham & Women's Hospital - Harvard Medical School Cancer Research Faculty Position Tulane University Health Sciences Center Postdoctoral Fellow - Breast Cancer Research Albert Einstein College Medicine PhD or Postdoc position in Cancer Bioinformatics VIB Center for the Biology of Disease, K.U.Leuven Outstanding Scientists Cancer Research UK Manchester Institute More Science jobs from Cancer EVENT American Association for Cancer Research Annual Meeting 2014 09.04.14 San Diego, USA More science events from
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REVIEWS		Top
Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms Eran Elinav, Roni Nowarski, Christoph A. Thaiss, Bo Hu, Chengcheng Jin & Richard A. Flavell p759 | doi:10.1038/nrc3611 The role of inflammation in tumorigenesis and tumour progression is increasingly coming into focus, and this Review discusses the current ideas about the mechanisms of inflammation-associated tumorigenesis and the association with the microbiota. Abstract | Full Text | PDF
Tyrosine kinase gene rearrangements in epithelial malignancies Alice T. Shaw, Peggy P. Hsu, Mark M. Awad & Jeffrey A. Engelman p772 | doi:10.1038/nrc3612 In this Review, the authors examine the aetiological, pathogenic and clinical features that are associated with cancers harbouring oncogenic fusion kinases, the clinical outcomes with targeted therapies, and strategies to discover additional kinases that are activated by chromosomal rearrangements in solid tumours. Abstract | Full Text | PDF | Supplementary information
The roles of TGFβ in the tumour microenvironment Michael Pickup, Sergey Novitskiy & Harold L. Moses p788 | doi:10.1038/nrc3603 The influence of the microenvironment on tumour progression is becoming clearer. This Review addresses the role of transforming growth factor-β in the regulation of components of the tumour microenvironment. Abstract | Full Text | PDF
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PERSPECTIVES		Top
OPINION The microbiome and cancer Robert F. Schwabe & Christian Jobin p800 | doi:10.1038/nrc3610 There is an emerging association between the microbiota and carcinogenesis. How might the microbiota modulate tumorigenesis, and what do we need to understand to more firmly conclude that the microbiome causes cancer? Abstract | Full Text | PDF
OPINION A central role for vesicle trafficking in epithelial neoplasia: intracellular highways to carcinogenesis James R. Goldenring p813 | doi:10.1038/nrc3601 This Opinion article outlines the roles of vesicle trafficking pathways in various phenotypes shown by cancer cells, especially loss of polarity and invasion, and argues that although these proteins are not drivers of transformation, they are integral to maintaining neoplastic phenotypes. Abstract | Full Text | PDF
Corrigendum: Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology Bengt Hallberg & Ruth H. Palmer p820 | doi:10.1038/nrc3614 Full Text | PDF
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Nature Collections TCGA pan-cancer analysis The Cancer Genome Atlas Pan-cancer initiative examines the similarities and differences among the genomic and cellular alterations found in the first dozen tumor types to be profiled by TCGA. This first look across cancer offers new tools in genomics and bioinformatics and the prospect of repurposing targeted therapies directed by the molecular pathology of the tumors in addition to their clinical classification. View the Collection and accompanying Podcast, FREE at:  www.nature.com/tcga Produced with support from Illumina
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*2012 Journal Citation Report (Thomson Reuters, 2013)

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