Nature Immunology Contents: November 2013 Volume 14 pp 1101 - 1198

TABLE OF CONTENTS November 2013 Volume 14, Issue 11 Correspondence Commentary News and Views Research Highlights Review Articles Resource Advertisement   Surface Plasmon Resonance (SPR) label-free interaction analysis systems Explore critical antibody-antigen interactions using Reichert Surface Plasmon Resonance systems. Kinetic (on/off rates), affinity and concentration data are generated, providing valuable insight into biological functions and facilitating therapeutic development.  ReichertSPR.com Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Just one of many high-quality articles from Frontiers in Immunology:  Cellular-level versus receptor-level response threshold hierarchies in T-cell activation (open access) In this original research article, the findings of Hugo Van Den Berg and colleagues elucidate the relationship between TCR/pMHCI kinetics and cellular function, thereby providing an integrated mechanistic understanding of T-cell response profiles.    Correspondence Top No antigen-presentation defect in Unc93b13d/3d (3d) mice   pp1101 - 1102 Jacques Deguine, Bettina L Lee, Zachary R Newman and Gregory M Barton doi:10.1038/ni.2733 See also: Correspondence by Tabeta et al. Respond to "No antigen-presentation defect in Unc93b13d/3d (3d) mice"   pp1102 - 1103 Koichi Tabeta, Kasper Hoebe, Edith M Janssen, Yu Xia and Bruce Beutler doi:10.1038/ni.2734 See also: Correspondence by Deguine et al. Commentary Top HIV-AIDS: much accomplished, much to do   pp1104 - 1107 Anthony S Fauci, Gregory K Folkers and Carl W Dieffenbach doi:10.1038/ni.2735 News and Views Top ADAPted secretion of cytokines in NK cells   pp1108 - 1110 Eric Vivier, Sophie Ugolini and Jacques A Nunès doi:10.1038/ni.2737 A signaling module consisting of the adaptor ADAP and the Carma1-Bcl-10-MALT1 (CBM)-TAK1 signalosome has been shown to selectively induce cytokine secretion but not cytotoxicity in natural killer cells. See also: Article by Rajasekaran et al. Polarized effector programs for innate-like thymocytes   pp1110 - 1111 Benjamin D McDonald, Michael G Constantinides and Albert Bendelac doi:10.1038/ni.2739 Distinct lineages of natural killer T cells arise in the thymus and are characterized by the signature transcription factors T-bet, GATA-3 or RORγt. See also: Article by Lee et al. You break it, you fix it: functions for AID downstream of deamination   pp1112 - 1114 Rebecca K Delker and F Nina Papavasiliou doi:10.1038/ni.2738 In a phosphorylation-dependent positive feedback loop, the cytidine deaminase AID amplifies the generation of double-strand DNA breaks, which shows it can also function downstream of deamination. See also: Article by Vuong et al. Bypassing T cell 'exhaustion'   pp1114 - 1116 Joachim R Göthert doi:10.1038/ni.2742 The hypoxia-inducible factor (HIF) pathway controls diverse aspects of the immunological response. Enhanced HIF activity is able to extend and potentiate the effector response of CD8+ T cells against chronic infections and tumor growth. See also: Article by Doedens et al. Immunology JOBS of the week Post-doc position in viro-immunology CIRI, Center for Infectiology Research Postdoctoral position in Molecular Immunology Baylor Institute for Immunology Research Postdoctoral Research Fellow in Immunology, Homburg, Germany Saarland University Hospital, Department of Internal Medicine, Nephrology and Hypertension Immunology PostDoc UT Health Science Center at Houston Junior Research Group Leader (M / F) German Cancer Research Center (DKFZ) More Science jobs from Immunology EVENT Malaria Immunology and Vaccination 2nd July 2014 London, UK More science events from Research Highlights Top A sirtuin switch in the brain | Lck availability | Peripheral Aire | Restricting HIV-1 | Dysfunctional T cells | Tolerogenic MUC2 Review Top Effect of helminth-induced immunity on infections with microbial pathogens   pp1118 - 1126 Padmini Salgame, George S Yap and William C Gause doi:10.1038/ni.2736 Under natural conditions, infections never occur in isolation, yet immunologists rarely consider the immunological outcome of multiple infections. In this Review, Gause and colleagues discuss how helminth infection affects antibacterial and antiviral responses. Articles Top Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells   pp1127 - 1136 Kamalakannan Rajasekaran, Pawan Kumar, Kristina M Schuldt, Erik J Peterson, Bart Vanhaesebroeck et al. doi:10.1038/ni.2708 Effector responses of NK cells occur via cytoxicity and cytokine secretion. Malarkannan and colleagues identify a signaling module that selectively controls the cytokine production of NK cells. See also: News and Views by Vivier et al. CD1d-lipid antigen recognition by the γδ TCR   pp1137 - 1145 Adam P Uldrich, Jérôme Le Nours, Daniel G Pellicci, Nicholas A Gherardin, Kirsty G McPherson et al. doi:10.1038/ni.2713 How γδ TCRs bind antigen presented by antigen-presenting molecules remains unclear. Godfrey and colleagues describe a population of human γδ T cells that interacts with CD1d and provide a molecular basis for how a γδ TCR binds CD1d-α-GalCer. Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells   pp1146 - 1154 You Jeong Lee, Keli L Holzapfel, Jinfang Zhu, Stephen C Jameson and Kristin A Hogquist doi:10.1038/ni.2731 Mature invariant natural killer T cells (iNKT cells) are an early innate source of cytokines. Hogquist and colleagues classify three lineages of iNKT cells by their distinct transcription factors and cytokine profiles. See also: News and Views by McDonald et al. The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells   pp1155 - 1165 Kevin Man, Maria Miasari, Wei Shi, Annie Xin, Darren C Henstridge et al. doi:10.1038/ni.2710 Clonal expansion of cytotoxic T lymphocytes entails profound energetic demands. Kallies and colleagues show that the transcription factor IRF4 is critical for the metabolic reprogramming, survival and effector function of these cells during clonal expansion. Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation   pp1166 - 1172 Christopher S Garris, Linfeng Wu, Swati Acharya, Ahmet Arac, Victoria A Blaho et al. doi:10.1038/ni.2730 S1P1 is a sphingosine phosphate receptor expressed on lymphocytes. Han and colleagues show that phosphorylated S1P1 accumulates in brain lesions of patients with multiple sclerosis. Similarly, mice bearing mutant S1P1 develop more severe experimental autoimmune encephalomyelitis. Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen   pp1173 - 1182 Andrew L Doedens, Anthony T Phan, Martin H Stradner, Jessica K Fujimoto, Jessica V Nguyen et al. doi:10.1038/ni.2714 The transcription factor HIF is induced in response to hypoxic stress, TCR activation and cytokines. Goldrath and colleagues show that HIF signaling enhances CTL effector responses and can render cells refractory to immune exhaustion. See also: News and Views by Gothert A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination   pp1183 - 1189 Bao Q Vuong, Kayleigh Herrick-Reynolds, Bharat Vaidyanathan, Joseph N Pucella, Anna J Ucher et al. doi:10.1038/ni.2732 The cytidine deaminase AID mediates immunoglobulin class-switch recombination. Chaudhuri and colleagues show that a phosphorylation-dependent positive feedback loop regulates AID activity and is initiated by DNA breaks. See also: News and Views by Delker & Papavasiliou Advertisement Multiplex your ELISA for greater productivity. The Bio-Plex® MAGPIX™ Multiplex Reader, combined with our intuitive software and wide selection of assays, makes multiplex immunoassays easy and affordable.   Resource Top Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation   pp1190 - 1198 Gangqing Hu, Qingsong Tang, Suveena Sharma, Fang Yu, Thelma M Escobar et al. doi:10.1038/ni.2712 Intergenic long noncoding RNAs (lincRNAs) regulate gene expression in various tissues. Zhao and colleagues identify 1,524 lincRNA clusters in thymocytes and mature T cell subsets and reveal dynamic and cell-specific patterns of lincRNA expression during T cell differentiation. Top Advertisement Nature Communications is ranked #3 in the Multidisciplinary Sciences with an Impact Factor of 10.015* Your research. Our reach. 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