Nature Biotechnology Contents: Volume 31 pp 857 - 942

TABLE OF CONTENTS October 2013 Volume 31, Issue 10 Editorial News News Feature Bioentrepreneur Opinion and Comment Features News and Views Computational Biology Research Careers and Recruitment Advertisement   Discover now Takyon™ qPCR kits for SYBR® and Probes assays. Emerging from the combination of an optimized reaction buffer and a new efficient enzyme, Takyon™ kits ensure sensitivity and fast delivery of accurate and reproducible results! Takyon™  was inspired by the faster than light particle, "Tachyon". Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement Frontiers in Bioengineering and Biotechnology is a new journal benefiting from the Frontiers Research network and open access publishing platform. We're building a highly regarded editorial board of outstanding scientists. We are currently looking for a Speciality Chief Editor for Biochemical and Biomolecular Engineering, amongst other key specialities in this field.  Be a part of the future of research publication.    Editorial Top In need of an upgrade   p857 doi:10.1038/nbt.2717 Improving the integration of computational analysis into biology will require better documentation, validation and accessibility of software associated with papers. News Top Amgen swallows Onyx whole   pp859 - 860 Malini Guha doi:10.1038/nbt1013-859 Courts defer ruling on science   p860 Jeffrey L Fox doi:10.1038/nbt1013-860 China clampdown on GSK linked to drug costs   p861 Hepeng Jia doi:10.1038/nbt1013-861 First mass spectrometry diagnostic approved in US   p862 Jennifer Rohn doi:10.1038/nbt1013-862a Scripps boosts research coffers by selling reagents to Sigma-Aldrich   pp862 - 864 Mark Ratner doi:10.1038/nbt1013-862b Elan's Irish tax allure   p864 Emily Waltz doi:10.1038/nbt1013-864 Neurodevice startups target peripheral nervous system   pp865 - 866 Michael Eisenstein doi:10.1038/nbt1013-865 Korea's 9 billion injection   p866 Allison Proffitt doi:10.1038/nbt1013-866 Mars collaborates to sequence Africa's neglected food crops   p867 Jeffrey L Fox doi:10.1038/nbt1013-867a Correction   p867 doi:10.1038/nbt1013-867b Correction   p867 doi:10.1038/nbt1013-867c From the bottom of a DNA cocktail glass   p868 Nuala Moran doi:10.1038/nbt1013-868 India's onslaught on drug patents continues   p869 Lisa Melton doi:10.1038/nbt1013-869a Around the world in a month   p869 doi:10.1038/nbt1013-869b News Feature Top Big oil turns on biofuels   pp870 - 873 Cormac Sheridan doi:10.1038/nbt.2704 Despite government incentives and mandates, second-generation biofuels are proving tough to bring to market. Cormac Sheridan investigates. Advertisement Biologics Analysis Workflow Increase electrophoresis throughput, simplify staining, and streamline imaging and data analysis with the Biologics Analysis Workflow - a proven, efficient way to assess the purity of biologics reproducibly in a cGMP-regulated environment. Leading labs have made the change easily and with little effort. View the comparability study. Bioentrepreneur Top Data Page Top US universities, institutes for life sciences in 2012   p874 Brady Huggett doi:10.1038/nbt.2719 Opinion and Comment Top Correspondence What is the point of large-scale collections of human induced pluripotent stem cells?   pp875 - 877 Ruth McKernan and Fiona M Watt doi:10.1038/nbt.2710 A proposal to use gamete cycling in vitro to improve crops and livestock   pp877 - 880 Seth C Murray, Philip Eckhoff, Lowell Wood and Andrew H Paterson doi:10.1038/nbt.2707 The regulatory landscape for actively personalized cancer immunotherapies   pp880 - 882 Cedrik M Britten, Harpreet Singh-Jasuja, Bruno Flamion, Axel Hoos, Christoph Huber et al. doi:10.1038/nbt.2708 The value of non-human primates in the development of monoclonal antibodies   pp882 - 883 P J K van Meer, M Kooijman, J W van der Laan, E H M Moors and H Schellekens doi:10.1038/nbt.2709 Features Top Patents DREAMing of a patent-free human genome for clinical sequencing   pp884 - 887 Kevin J McKernan, Jessica Spangler, Yvonne Helbert, Lei Zhang and Vasisht Tadigotla doi:10.1038/nbt.2703 Can methylation be the key to challenging the interpretation of existing gene patent claims? And can a novel PCR method be used to enable the sequencing of hundreds of genes? Recent patent applications in DNA sequencing   p888 doi:10.1038/nbt.2724 News and Views Top Phospho-specific antibodies by design   pp889 - 891 Oda Stoevesandt and Michael J Taussig doi:10.1038/nbt.2712 Antibodies specific to phosphorylated peptides are readily generated through structure-based engineering and in vitro selection. See also: Research by Koerber et al. Modified RNA kick-starts cardiac repair   pp891 - 892 Seppo Yla-Herttuala and Einari Aavik doi:10.1038/nbt.2716 The survival of mice after experimental heart attack is greatly improved by a pulse of RNA therapy. See also: Research by Zangi et al. Differences that matter in cancer genomics   pp892 - 893 Li Ding and Michael C Wendl doi:10.1038/nbt.2715 Correcting for mutational heterogeneity within and between tumor samples improves cancer genome analyses. Research Highlights   p893 doi:10.1038/nbt.2718 Biotechnology JOBS of the week Director, Institute of Biotechnology and Pharmaceutical Research National Health Research Institutes (NHRI) QA GMP Expert - Biotechnology Company / Brussels area, Belgium Pharma Professionals Europe Ltd. 1020BR Scientist / Sr. Scientist - Metabolic Disease Group Regeneron Pharmaceuticals, Inc. Postdoctoral Fellow Medical University of South Carolina Biology of Cancer - (Tenure-Track or Tenured) Department of Molecular and Cell Biology More Science jobs from Biotechnology EVENT Australia Biotech Invest 2013 October 28-29, 2013 Australia More science events from Computational Biology Top Feature The anatomy of successful computational biology software   pp894 - 897 Stephen Altschul, Barry Demchak, Richard Durbin, Robert Gentleman, Martin Krzywinski et al. doi:10.1038/nbt.2721 Creators of software widely used in computational biology discuss the factors that contributed to their success Research Top Articles Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction   pp898 - 907 Lior Zangi, Kathy O Lui, Alexander von Gise, Qing Ma, Wataru Ebina et al. doi:10.1038/nbt.2682 Pulse-like expression of VEGF-A from modified RNA extends survival in a mouse model of myocardial infarction. See also: News and Views by Yla-Herttuala & Aavik Accelerating the design of biomimetic materials by integrating RNA-seq with proteomics and materials science   pp908 - 915 Paul A Guerette, Shawn Hoon, Yiqi Seow, Manfred Raida, Admir Masic et al. doi:10.1038/nbt.2671 The engineering of biomimetic materials is accelerated by combining high-throughput RNA sequencing and proteomics. Nature-inspired design of motif-specific antibody scaffolds   pp916 - 921 James T Koerber, Nathan D Thomsen, Brett T Hannigan, William F Degrado and James A Wells doi:10.1038/nbt.2672 Engineering motif-specific 'hot spots' into an antibody scaffold yields antibodies with high affinity to targets containing phosphoserine, phosphothreonine or phosphotyrosine. See also: News and Views by Stoevesandt & Taussig Identifying producers of antibacterial compounds by screening for antibiotic resistance   pp922 - 927 Maulik N Thaker, Wenliang Wang, Peter Spanogiannopoulos, Nicholas Waglechner, Andrew M King et al. doi:10.1038/nbt.2685 Selecting for microorganisms resistant to known antibiotics enables discovery of strains that produce structurally related compounds. Letters Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy   pp928 - 933 Maria Themeli, Christopher C Kloss, Giovanni Ciriello, Victor D Fedorov, Fabiana Perna et al. doi:10.1038/nbt.2678 T cells generated from human iPSCs engineered to express a chimeric antigen receptor display innate lymphoid properties and inhibit tumor growth in mice. Conditional targeted genome editing using somatically expressed TALENs in C. elegans    pp934 - 937 Ze Cheng, Peishan Yi, Xiangming Wang, Yongping Chai, Guoxin Feng et al. doi:10.1038/nbt.2674 TALENs expressed in somatic cells under the control of tissue-specific or inducible promoters generate conditional knockouts in C. elegans. Careers and Recruitment Top The missing piece to changing the university culture   pp938 - 941 Maximiliaan Schillebeeckx, Brett Maricque and Cory Lewis doi:10.1038/nbt.2706 A new type of initiative is empowering graduate students and postdocs to reshape their academic training, providing another avenue to express their passion for research. People People   p942 doi:10.1038/nbt.2723 Top Advertisement nature.com webcasts Macmillan Science Communication presents a custom webcast on: Multi-omics in metabolic disease: investigating the potential to predict diabetes Friday October 11th 7am PDT / 10am EDT / 3pm BST / 4pm CEST  Register for the free webcast followed by our live Q & A session  Sponsored by:      Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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