Molecular Systems Biology - New articles published 29 October 2013

Latest Articles 29th October 2013   Featured Article Research Articles News and Views   Web feeds About Open access Advertisement Molecular Systems Biology - Resources  A yeast one-hybrid and microfluidics-based pipeline to map mammalian gene regulatory networks Bart Deplancke   The functional interactome landscape of the human histone deacetylase family Ileana Cristea   A global S. cerevisiae small ubiquitin-related modifier (SUMO) system interactome Brian Raught      Featured Article Promoters maintain their relative activity levels under different growth conditions Libraries of S. cerevisiae and E. coli promoter reporters measured under different conditions reveal scaling relationships between expression profiles across conditions and suggest that most changes in activity are due to global effects. Leeat Keren, Ora Zackay, Maya Lotan-Pompan, Uri Barenholz, Erez Dekel, Vered Sasson, Guy Aidelberg, Anat Bren, Danny Zeevi, Adina Weinberger, Uri Alon, Ron Milo & Eran Segal Molecular Systems Biology 9:701; doi:10.1038/msb.2013.59; published 29 October 2013 Full Text | PDF | Supp. Inf. | Review Process Research Articles Sequential induction of auxin efflux and influx carriers regulates lateral root emergence Emergence of a new lateral root primordium through the outer layers of the parental root requires the sequential auxin-mediated induction of two auxin transporters. This positive feedback regulatory loop coordinates patterned gene expression in outer tissues. Benjamin Péret, Alistair M Middleton, Andrew P French, Antoine Larrieu, Anthony Bishopp, Maria Njo, Darren M Wells, Silvana Porco, Nathan Mellor, Leah R Band, Ilda Casimiro, Jürgen Kleine-Vehn, Steffen Vanneste, Ilkka Sairanen, Romain Mallet, Göran Sandberg, Karin Ljung, Tom Beeckman, Eva Benkova, Jiří Friml, Eric Kramer, John R King, Ive De Smet, Tony Pridmore, Markus Owen & Malcolm J Bennett Molecular Systems Biology 9:699; doi:10.1038/msb.2013.43; published 22 October 2013 Full Text | PDF | Supp. Inf. | Review Process Design of orthogonal genetic switches based on a crosstalk map of σs, anti-σs, and promoters The interaction specificities of extracytoplasmic function (ECF) sigma (σ) factors with promoters and their negative regulators (anti-σs) were mapped to identify non-crossreacting parts. These orthogonal sets represent a synthetic biology toolbox of genetic switches. Virgil A Rhodius, Thomas H Segall-Shapiro, Brian D Sharon, Amar Ghodasara, Ekaterina Orlova, Hannah Tabakh, David H Burkhardt, Kevin Clancy, Todd C Peterson, Carol A Gross & Christopher A Voigt Molecular Systems Biology 9:702; doi:10.1038/msb.2013.58; published 29 October 2013 Full Text | PDF | Supp. Inf. | Review Process Bacterial evolution of antibiotic hypersensitivity Understanding how adaptation to a given antibiotic increases the sensitivity to other antibiotics is of great medical importance for the understanding of evolutionary trade-offs. Here, the first experimental map of such collateral sensitivity is presented, along with insights into the underlying mechanisms. Viktória Lázár, Gajinder Pal Singh, Réka Spohn, István Nagy, Balázs Horváth, Mónika Hrtyan, Róbert Busa-Fekete, Balázs Bogos, Orsolya Méhi, Bálint Csörgő, György Pósfai, Gergely Fekete, Balázs Szappanos, Balázs Kégl, Balázs Papp & Csaba Pál Molecular Systems Biology 9:700; doi:10.1038/msb.2013.57; published 29 October 2013 Full Text | PDF | Supp. Inf. | Review Process News and Views Root systems analysis branches out Klaus Palme, & William Teale Molecular Systems Biology 9:698; doi:10.1038/msb.2013.51; published 22 October 2013 Full Text | PDF     You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.