 | | Featured Article | |  | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities |
| This study defines a network of synthetic sick/lethal interactions with a set of query genes in a series of isogenic cancer cell lines. Analysis of differential essentiality reveals general properties in genetic interaction networks derived from studies on model organisms. Franco J Vizeacoumar, Roland Arnold, Frederick S Vizeacoumar, Megha Chandrashekhar, Alla Buzina, Jordan T F Young, Julian H M Kwan, Azin Sayad, Patricia Mero, Steffen Lawo, Hiromasa Tanaka, Kevin R Brown, Anastasia Baryshnikova, Anthony B Mak, Yaroslav Fedyshyn, Yadong Wang, Glauber C Brito, Dahlia Kasimer, Taras Makhnevych, Troy Ketela, Alessandro Datti, Mohan Babu, Andrew Emili, Laurence Pelletier, Jeff Wrana, Zev Wainberg, Philip M Kim, Robert Rottapel, Catherine A O’Brien, Brenda Andrews, Charles Boone & Jason Moffat Molecular Systems Biology 9:696; doi:10.1038/msb.2013.54; published 8 October 2013 Full Text | PDF | Supp. Inf. | Review Process | | Research Articles | |  | A competitive protein interaction network buffers Oct4-mediated differentiation to promote pluripotency in embryonic stem cells |
| The dynamic competition for complex formation between the pluripotency network components Oct4, Nanog, Tcf3, and β-catenin prevents embryonic stem cell differentiation by controlling the levels of free Oct4. Silvia Muñoz Descalzo, Pau Rué, Fernando Faunes, Penelope Hayward, Lars Martin Jakt, Tina Balayo, Jordi Garcia-Ojalvo & Alfonso Martinez Arias Molecular Systems Biology 9:694; doi:10.1038/msb.2013.49; published 8 October 2013 Full Text | PDF | Supp. Inf. | Review Process | | |  | Natural sequence variants of yeast environmental sensors confer cell-to-cell expression variability |
| DNA polymorphisms that change cell-to-cell variability in gene expression are identified in a screen for ‘Probabilistic Trait Loci’ in yeast. By modifying transmembrane transporter genes, these natural variants modulate intraclonal phenotypic diversification. Steffen Fehrmann, Hélène Bottin-Duplus, Andri Leonidou, Esther Mollereau, Audrey Barthelaix, Wu Wei, Lars M Steinmetz & Gaël Yvert Molecular Systems Biology 9:695; doi:10.1038/msb.2013.53; published 8 October 2013 Full Text | PDF | Supp. Inf. | Review Process | | |  | Temporal control of self-organized pattern formation without morphogen gradients in bacteria |
| The generation of self-organized ring patterns of gene expression in the absence of a morphogen gradient was demonstrated using bacteria programmed by a synthetic gene circuit. This work presents a timing mechanism of pattern formation. Stephen Payne, Bochong Li, Yangxiaolu Cao, David Schaeffer, Marc D Ryser & Lingchong You Molecular Systems Biology 9:697; doi:10.1038/msb.2013.55; published 8 October 2013 Full Text | PDF | Supp. Inf. | Review Process | |
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