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|  |  |  | Volume 27, Issue 10 (October 2013) |  | In this issue
Reviews
Original Articles
Letters to the Editor
Corrigenda
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|  |  | Reviews | Top |  | Problems and pitfalls regarding WHO-defined diagnosis of early/prefibrotic primary myelofibrosis versus essential thrombocythemiaT Barbui, J Thiele, A M Vannucchi and A Tefferi Leukemia 2013 27: 1953-1958; advance online publication, March 7, 2013; 10.1038/leu.2013.74 Abstract | Full Text |  |  |  | Review of health-related quality of life data in multiple myeloma patients treated with novel agents OPENP Sonneveld, S G Verelst, P Lewis, V Gray-Schopfer, A Hutchings, A Nixon and M T Petrucci Leukemia 2013 27: 1959-1969; advance online publication, June 20, 2013; 10.1038/leu.2013.185 Abstract | Full Text |  | Original Articles | Top |  | ACUTE LEUKEMIAS
| Role of cysteine 288 in nucleophosmin cytoplasmic mutations: sensitization to toxicity induced by arsenic trioxide and bortezomibM Huang, D Thomas, M X Li, W Feng, S M Chan, R Majeti and B S Mitchell Leukemia 2013 27: 1970-1980; advance online publication, July 23, 2013; 10.1038/leu.2013.222 Abstract | Full Text |  |  |  | MYELODYSPLASIAS
| Flow cytometric detection of dyserythropoiesis: a sensitive and powerful diagnostic tool for myelodysplastic syndromesS Mathis, N Chapuis, C Debord, A Rouquette, I Radford-Weiss, S Park, F Dreyfus, C Lacombe, M C Béné, O Kosmider, M Fontenay and V Bardet Leukemia 2013 27: 1981-1987; advance online publication, June 14, 2013; 10.1038/leu.2013.178 Abstract | Full Text |  |  |  | Monosomal karyotype in MDS: explaining the poor prognosis?J Schanz, H Tüchler, F Solé, M Mallo, E Luño, J Cervera, J Grau, B Hildebrandt, M L Slovak, K Ohyashiki, C Steidl, C Fonatsch, M Pfeilstöcker, T Nösslinger, P Valent, A Giagounidis, C Aul, M Lübbert, R Stauder, O Krieger, M M Le Beau, J M Bennett, P Greenberg, U Germing and D Haase Leukemia 2013 27: 1988-1995; advance online publication, June 21, 2013; 10.1038/leu.2013.187 Abstract | Full Text |  |  |  | CHRONIC MYELOPROLIFERATIVE NEOPLASIAS
| Bcl-xL anti-apoptotic network is dispensable for development and maintenance of CML but is required for disease progression where it represents a new therapeutic targetJ G Harb, P Neviani, B J Chyla, J J Ellis, G J Ferenchak, J J Oaks, C J Walker, P Hokland, D C Roy, M A Caligiuri, G Marcucci, C S Huettner and D Perrotti Leukemia 2013 27: 1996-2005; advance online publication, May 14, 2013; 10.1038/leu.2013.151 Abstract | Full Text |  |  |  | Physiologic corticosterone oscillations regulate murine hematopoietic stem/progenitor cell proliferation and CXCL12 expression by bone marrow stromal progenitorsO Kollet, Y Vagima, G D'Uva, K Golan, J Canaani, T Itkin, S Gur-Cohen, A Kalinkovich, G Caglio, C Medaglia, A Ludin, K Lapid, E Shezen, A Neufeld-Cohen, D Varol, A Chen and T Lapidot Leukemia 2013 27: 2006-2015; advance online publication, May 17, 2013; 10.1038/leu.2013.154 Abstract | Full Text |  |  |  | The EUTOS prognostic score: review and validation in 1288 patients with CML treated frontline with imatinibV S Hoffmann, M Baccarani, D Lindoerfer, F Castagnetti, A Turkina, A Zaritsky, A Hellmann, W Prejzner, J-L Steegmann, J Mayer, K Indrak, A Colita, G Rosti and M Pfirrmann Leukemia 2013 27: 2016-2022; advance online publication, June 11, 2013; 10.1038/leu.2013.171 Abstract | Full Text |  |  |  | STEM CELLS
| A stem cell-like gene expression signature associates with inferior outcomes and a distinct microRNA expression profile in adults with primary cytogenetically normal acute myeloid leukemiaK H Metzeler, K Maharry, J Kohlschmidt, S Volinia, K Mrózek, H Becker, D Nicolet, S P Whitman, J H Mendler, S Schwind, A-K Eisfeld, Y-Z Wu, B L Powell, T H Carter, M Wetzler, J E Kolitz, M R Baer, A J Carroll, R M Stone, M A Caligiuri, G Marcucci and C D Bloomfield Leukemia 2013 27: 2023-2031; advance online publication, June 14, 2013; 10.1038/leu.2013.181 Abstract | Full Text |  |  |  | MINIMAL RESIDUAL DISEASE
| Establishing optimal quantitative-polymerase chain reaction assays for routine diagnosis and tracking of minimal residual disease in JAK2-V617F-associated myeloproliferative neoplasms: a joint European LeukemiaNet/MPN&MPNr-EuroNet (COST action BM0902) study OPENJ V Jovanovic, A Ivey, A M Vannucchi, E Lippert, E Oppliger Leibundgut, B Cassinat, N Pallisgaard, N Maroc, S Hermouet, G Nickless, P Guglielmelli, B A van der Reijden, J H Jansen, T Alpermann, S Schnittger, A Bench, K Tobal, B Wilkins, K Cuthill, D McLornan, K Yeoman, S Akiki, J Bryon, S Jeffries, A Jones, M J Percy, S Schwemmers, A Gruender, T W Kelley, S Reading, A Pancrazzi, M F McMullin, H L Pahl, N C P Cross, C N Harrison, J T Prchal, C Chomienne, J J Kiladjian, T Barbui and D Grimwade Leukemia 2013 27: 2032-2039; advance online publication, July 17, 2013; 10.1038/leu.2013.219 Abstract | Full Text |  |  |  | NORMAL HEMOPOIESIS
| mTOR regulates DNA damage response through NF-κB-mediated FANCD2 pathway in hematopoietic cellsF Guo, J Li, W Du, S Zhang, M O'Connor, G Thomas, S Kozma, B Zingarelli, Q Pang and Y Zheng Leukemia 2013 27: 2040-2046; advance online publication, March 29, 2013; 10.1038/leu.2013.93 Abstract | Full Text |  |  |  | TRANSCRIPTIONAL CONTROL AND SIGNAL TRANSDUCTION
| The eukaryotic translation initiation factor eIF4E is a direct transcriptional target of NF-κB and is aberrantly regulated in acute myeloid leukemiaF Hariri, M Arguello, L Volpon, B Culjkovic-Kraljacic, T H Nielsen, J Hiscott, K K Mann and K L B Borden Leukemia 2013 27: 2047-2055; advance online publication, March 7, 2013; 10.1038/leu.2013.73 Abstract | Full Text |  |  |  | MYELOMA
| A multiparameter flow cytometry immunophenotypic algorithm for the identification of newly diagnosed symptomatic myeloma with an MGUS-like signature and long-term disease controlB Paiva, M-B Vídriales, L Rosiñol, J Martínez-López, M-V Mateos, E M Ocio, M-Á Montalbán, L Cordón, N C Gutiérrez, L Corchete, A Oriol, M-J Terol, M-A Echeveste, R De Paz, F De Arriba, L Palomera, J de la Rubia, J Díaz-Mediavilla, M Granell, A Gorosquieta, A Alegre, A Orfao, J-J Lahuerta, J Bladé and J F San Miguel on behalf of the GEM (Grupo Español de MM)/PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatías Malignas) cooperative study group Leukemia 2013 27: 2056-2061; advance online publication, June 7, 2013; 10.1038/leu.2013.166 Abstract | Full Text |  |  |  | Long-term outcome with lenalidomide and dexamethasone therapy for newly diagnosed multiple myelomaG Srivastava, V Rana, M Q Lacy, F K Buadi, S R Hayman, A Dispenzieri, M A Gertz, D Dingli, S Zeldenrust, S Russell, A McCurdy, P Kapoor, R Kyle, S V Rajkumar and S Kumar Leukemia 2013 27: 2062-2066; advance online publication, May 7, 2013; 10.1038/leu.2013.143 Abstract | Full Text |  | Letters to the Editor | Top |  | Degree of focal immunoglobulin heavy chain locus deletion as a measure of B-cell tumor purityP L Bergsagel and W M Kuehl Leukemia 2013 27: 2067-2068; advance online publication, May 6, 2013; 10.1038/leu.2013.139 Full Text |  |  |  | Early intervention with allogeneic hematopoietic cell transplantation during chemotherapy-induced aplasia in patients with high-risk acute myeloid leukemiaF Stölzel, U Platzbecker, B Mohr, C Röllig, J M Middeke, C Thiede, M Füssel, M Hänel, M Schaich, G Ehninger, J Schetelig and M Bornhäuser Leukemia 2013 27: 2068-2072; advance online publication, May 7, 2013; 10.1038/leu.2013.142 Full Text |  |  |  | SETBP1 mutation analysis in 944 patients with MDS and AMLF Thol, K J Suchanek, C Koenecke, M Stadler, U Platzbecker, C Thiede, T Schroeder, G Kobbe, S Kade, P Löffeld, S Banihosseini, G Bug, O Ottmann, W-K Hofmann, J Krauter, N Kröger, A Ganser and M Heuser Leukemia 2013 27: 2072-2075; advance online publication, May 7, 2013; 10.1038/leu.2013.145 Full Text |  |  |  | Reduced CXCR4 expression is associated with extramedullary disease in a mouse model of myeloma and predicts poor survival in multiple myeloma patients treated with bortezomibH A F Stessman, A Mansoor, F Zhan, S Janz, M A Linden, L B Baughn and B Van Ness Leukemia 2013 27: 2075-2077; advance online publication, May 14, 2013; 10.1038/leu.2013.148 Full Text |  |  |  | NRAS mutations with low allele burden have independent prognostic significance for patients with lower risk myelodysplastic syndromesD M Murphy, R Bejar, K Stevenson, D Neuberg, Y Shi, C Cubrich, K Richardson, P Eastlake, G Garcia-Manero, H Kantarjian, B L Ebert and G Mike Makrigiorgos Leukemia 2013 27: 2077-2081; advance online publication, May 27, 2013; 10.1038/leu.2013.160 Full Text |  |  |  | Dynamic acquisition of FLT3 or RAS alterations drive a subset of patients with lower risk MDS to secondary AMLK Takahashi, E Jabbour, X Wang, R Luthra, C Bueso-Ramos, K Patel, S Pierce, H Yang, Y Wei, N Daver, S Faderl, F Ravandi, Z Estrov, J Cortes, H Kantarjian and G Garcia-Manero Leukemia 2013 27: 2081-2083; advance online publication, June 7, 2013; 10.1038/leu.2013.165 Full Text |  |  |  | Elevated C-reactive protein is associated with shortened leukemia-free survival in patients with myelofibrosisT Barbui, A Carobbio, G Finazzi, P Guglielmelli, S Salmoiraghi, V Rosti, A Rambaldi, A M Vannucchi and G Barosi Leukemia 2013 27: 2084-2086; advance online publication, July 5, 2013; 10.1038/leu.2013.207 Full Text |  |  |  | The CIBMTR score predicts survival of AML patients undergoing allogeneic transplantation with active disease after a myeloablative or reduced intensity conditioning: a retrospective analysis of the Gruppo Italiano Trapianto Di Midollo Osseo OPENE Todisco, F Ciceri, E Oldani, C Boschini, C Micò, M T VanLint, I Donnini, F Patriarca, P E Alessandrino, F Bonifazi, W Arcese, W Barberi, P Marenco, E Terruzzi, S Cortelazzo, S Santarone, A Proia, P Corradini, E Tagliaferri, S Falcioni, G Irrera, L Dallanegra, L Castagna, A Santoro, A Camboni, N Sacchi, A Bosi, A Bacigalupo and A Rambaldi Leukemia 2013 27: 2086-2091; advance online publication, July 9, 2013; 10.1038/leu.2013.208 Full Text |  |  |  | Clonal mast cell disease not meeting WHO criteria for diagnosis of mastocytosis: clinicopathologic features and comparison with indolent mastocytosisA Pardanani, D Chen, R A Abdelrahman, K K Reichard, D Zblewski, A J Wood, R F McClure, J H Butterfield, C A Hanson and A Tefferi Leukemia 2013 27: 2091-2094; advance online publication, July 30, 2013; 10.1038/leu.2013.227 Full Text |  |  |  | CX-4945, a selective inhibitor of casein kinase-2 (CK2), exhibits anti-tumor activity in hematologic malignancies including enhanced activity in chronic lymphocytic leukemia when combined with fludarabine and inhibitors of the B-cell receptor pathwayR C Prins, R T Burke, J W Tyner, B J Druker, M M Loriaux and S E Spurgeon Leukemia 2013 27: 2094-2096; advance online publication, July 31, 2013; 10.1038/leu.2013.228 Full Text |  |  |  | γ-Catenin is expressed throughout normal human hematopoietic development and is required for normal PU.1-dependent monocyte differentiationR G Morgan, K Liddiard, L Pearn, S L Pumford, A K Burnett, R L Darley and A Tonks Leukemia 2013 27: 2096-2100; advance online publication, April 2, 2013; 10.1038/leu.2013.96 Full Text |  |  |  | SETBP1 mutations in 415 patients with primary myelofibrosis or chronic myelomonocytic leukemia: independent prognostic impact in CMML OPENR R Laborde, M M Patnaik, T L Lasho, C M Finke, C A Hanson, R A Knudson, R P Ketterling, A Pardanani and A Tefferi Leukemia 2013 27: 2100-2102; advance online publication, April 5, 2013; 10.1038/leu.2013.97 Full Text |  |  |  | Baseline differential blood count and prognosis in CD20-positive post-transplant lymphoproliferative disorder in the prospective PTLD-1 trialH Zimmermann, S Choquet, J Moore, G Salles, F Morschhauser, T Lamy, A Jaccard, H A Horst, M Leithäuser, U Dührsen, P Reinke, Y Lebranchu, R Neuhaus, H Lehmkuhl, C Tarella, P Schlattmann, H Riess, V Leblond and R U Trappe for the German PTLD study group and the European PTLD Network Leukemia 2013 27: 2102-2105; advance online publication, April 15, 2013; 10.1038/leu.2013.110 Full Text |  |  |  | Distribution of genomic breakpoints in chronic myeloid leukemia: analysis of 308 patientsD M Ross, M O'Hely, P A Bartley, P Dang, J Score, J M Goyne, M Sobrinho-Simoes, N C P Cross, J V Melo, T P Speed, T P Hughes and A A Morley Leukemia 2013 27: 2105-2107; advance online publication, April 16, 2013; 10.1038/leu.2013.116 Full Text |  |  |  | Computational dissection of distinct microRNA activity signatures associated with peripheral T cell lymphoma subtypesH I Suzuki, H Matsuyama, M Noguchi, T Yao, N Komatsu, H Mano, K Sugimoto and K Miyazono Leukemia 2013 27: 2107-2111; advance online publication, April 18, 2013; 10.1038/leu.2013.121 Full Text |  | Corrigenda | Top |  | A multiparameter flow cytometry immunophenotypic algorithm for the identification of newly diagnosed symptomatic myeloma with an MGUS-like signature and long-term disease controlB Paiva, M-B Vídriales, L Rosiñol, J Martínez-López, M-V Mateos, E M Ocio, M-Á Montalbán, L Cordón, N C Gutiérrez, L Corchete, A Oriol, M-J Terol, M-A Echeveste, R De Paz, F De Arriba, L Palomera, J de la Rubia, J Díaz-Mediavilla, M Granell, A Gorosquieta, A Alegre, A Orfao, J-J Lahuerta, J Bladé and J F San Miguel on behalf of the GEM (Grupo Español de MM)/PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatías Malignas) cooperative study group Leukemia 2013 27: 2112; 10.1038/leu.2013.213 Full Text |  |  |  | Mayo prognostic model for WHO-defined chronic myelomonocytic leukemia: ASXL1 and spliceosome component mutations and outcomesM M Patnaik, E Padron, R R LaBorde, T L Lasho, C M Finke, C A Hanson, J M Hodnefield, R A Knudson, R P Ketterling, A Al-kali, A Pardanani, N A Ali, R S Komrokji and A Tefferi Leukemia 2013 27: 2112; 10.1038/leu.2013.229 Full Text |  |  |  |  | | Advertisement |  | |  |  |  |  |  |  |  |  |  | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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