Laboratory Investigation - Table of Contents alert Volume 93 Issue 11

Advertisement CINtec® p16 Histology Empowering your comprehensive evaluation of cervical biopsies. CINtec p16 Histology biomarker results reveal more information than H&E alone. Now available in a ready-to-use dispenser. Fully automated on VENTANA BenchMark XT and BenchMark Ultra IHC/ISH staining instruments using Optiview DAB IHC or ultraView DAB detection. TABLE OF CONTENTS Volume 93, Issue 11 (November 2013) In this issue Inside LI Research Articles Sign up for e-alerts Recommend to your library Web feed Subscribe Inside LI Top Inside Lab Invest 2013 93: 1168-1169; 10.1038/labinvest.2013.117 Full Text Research Articles Top GENITOURINARY AND REPRODUCTIVE SYSTEMS Advanced glycation end products suppress lysyl oxidase and induce bone collagen degradation in a rat model of renal osteodystrophy Renal osteodystrophy (ROD) is a mineral and bone disorder characterized by high risk of fracture and low mortality. This work describes the regulatory role of advanced glycation end products (AGEs) in lysyl oxidase expression, and bone collagen degradation associated with accumulation of AGEs in osteoblasts in a rat model of ROD. These findings may provide clues to ROD pathogenesis. Chiharu Aoki, Kenta Uto, Kazuho Honda, Yoshiharu Kato and Hideaki Oda 2013 93: 1170-1183; advance online publication, August 26, 2013; 10.1038/labinvest.2013.105 Abstract | Full Text Transcriptional upregulation of HIF-1α by NF-κB/p65 and its associations with β-catenin/p300 complexes in endometrial carcinoma cells In endometrial carcinoma, hypoxia-inducible factor-1α (HIF-1α) expression correlates with tumor aggressiveness and is a regulator of tumor cell adaption to radiation therapy and hypoxia. This study reveals that transcriptional association of HIF-1α and NF-κB, as well as β-catenin/p300 complexes, may contribute to changes in tumor cell kinetics in response to microenvironmental hypoxia in endometrial carcinoma. Tsutomu Yoshida, Miki Hashimura, Toshihide Mastumoto, Yuki Tazo, Hisako Inoue, Takeshi Kuwata and Makoto Saegusa 2013 93: 1184-1193; advance online publication, September 16, 2013; 10.1038/labinvest.2013.111 Abstract | Full Text BLOOD, LYMPHATICS, IMMUNE SYSTEM AND STEM CELLS Auto-antibodies to vascular endothelial cadherin in humans: association with autoimmune diseases Circulating auto-antibodies to vascular endothelial-cadherin (AAVEs) are found in patients with early-stage autoimmune diseases. This paper demonstrate a potential pathogenic effect of AAVEs isolated from patients with dysimmune disease. AAVEs are therefore potential biomarkers for endothelial injury in the early pathogenicity of autoimmune disorders. L Bouillet, A E Baudet, A Deroux, A Sidibé, C Dumestre-Perard, T Mannic, B Treillard, M A Arboleas, C A Chiquet, D G Gulino-Debrac and I Y Vilgrain 2013 93: 1194-1202; advance online publication, September 23, 2013; 10.1038/labinvest.2013.106 Abstract | Full Text The Hippo signaling pathway is required for salivary gland development and its dysregulation is associated with Sjogren's syndrome Sjogren's syndrome (SS) is a chronic autoimmune disease of salivary and lacrimal glands. This paper shows that the Hippo signaling pathway, which functions downstream from E-cadherin-mediated cell-cell adhesion, is disrupted in SS. These findings add a new mechanism to the molecular model for the underlying pathology of SS. Tone B Enger, Arman Samad-Zadeh, Meghan P Bouchie, Kathrine Skarstein, Hilde K Galtung, Toshiyuki Mera, Janice Walker, A Sue Menko, Xaralabos Varelas, Denise L Faustman, Janicke L Jensen and Maria A Kukuruzinska 2013 93: 1203-1218; advance online publication, September 30, 2013; 10.1038/labinvest.2013.114 Abstract | Full Text ANGIOGENESIS, CARDIOVASCULAR AND PULMONARY SYSTEMS All-transretinoic acid ameliorates bleomycin-induced lung fibrosis by downregulating the TGF-β1/Smad3 signaling pathway in rats There are no known medications that can prevent or reverse lung fibrogenesis. However, the transforming growth factor-β1 (TGF-β1)/Smad3 signaling pathway is a potential therapeutic target because it plays a central role in the pathogenesis of lung fibrosis. In the present study, the authors reveal that all-trans retinoic acid attenuates lung fibrosis through regulation of TGF-β1/Smad3 signaling, suggesting that it may have potential therapeutic value in treatment this condition. Xiaodong Song, Weili Liu, Shuyang Xie, Meirong Wang, Guohong Cao, Cuiping Mao and Changjun Lv 2013 93: 1219-1231; advance online publication, September 16, 2013; 10.1038/labinvest.2013.108 Abstract | Full Text BREAST, SKIN, SOFT TISSUE AND BONE In vitro and in silico studies of MDM2/MDMX isoforms predict Nutlin-3A sensitivity in well/de-differentiated liposarcomas The molecular hallmark of well-differentiated/de-differentiated liposarcomas (WD/DD LPS) is MDM2 gene amplification. This paper explores the therapeutic potential of MDM2 antagonist Nutlin-3A. MDM2 and its homologue, MDMX, are transcribed as several different splice variants with different affinities for Nutlin-3A, and the distinct protein isoforms are expressed at varying levels. These findings therefore predict heterogeneous patient responses to Nutlin 3A. Fabio Bozzi, Elena Conca, Erik Laurini, Paola Posocco, Alessandra Lo Sardo, Genny Jocollè, Roberta Sanfilippo, Alessandro Gronchi, Federica Perrone, Elena Tamborini, Giuseppe Pelosi, Marco A Pierotti, Roberta Maestro, Sabrina Pricl and Silvana Pilotti 2013 93: 1232-1240; advance online publication, September 9, 2013; 10.1038/labinvest.2013.107 Abstract | Full Text MODELS AND TECHNIQUES Specific transduction and labeling of pancreatic ducts by targeted recombinant viral infusion into mouse pancreatic ducts The authors describe an improved technique for duct-specific labeling of cells after the infusion of recombinant adeno-associated virus into the mouse common biliary/pancreatic duct. This technique could greatly enhance the ability to study the pancreatic ductal cell contribution to pancreatic endocrine development, function and pathology. Ping Guo, Xiangwei Xiao, Yousef El-Gohary, Angela Criscimanna, Krishna Prasadan, Christopher Rymer, Chiyo Shiota, John Wiersch, Iliana Gaffar, Farzad Esni and George K Gittes 2013 93: 1241-1253; advance online publication, October 7, 2013; 10.1038/labinvest.2013.113 Abstract | Full Text Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells This paper describes the establishment of a system for monitoring the dynamic endoplasmic reticulum (ER) redox state in mammalian cells. This system can be used to study the mechanisms of ER redox regulation, and provides a foundation for an approach to develop novel therapeutic modalities for human diseases related to dysregulated ER homeostasis. Kohsuke Kanekura, Shinsuke Ishigaki, Philip I Merksamer, Feroz R Papa and Fumihiko Urano 2013 93: 1254-1258; advance online publication, September 16, 2013; 10.1038/labinvest.2013.112 Abstract | Full Text Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Laboratory Investigation. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. 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