EMBO Reports - Table of Contents alert Volume 14 Issue 10, pp 847 - 945

TABLE OF CONTENTS October 2013 | Volume 14, Issue 10 Upfront Science & Society Review Scientific Reports Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement Top Downloads in 2013   The multifaceted role of mTORC1 in the control of lipid metabolism Stéphane Ricoult & Brendan Manning   Mechanosensitivity and compositional dynamics of cell–matrix adhesions Herbert Schiller & Reinhard Fässler  Upfront Top Editorial Had enough of that crummy stuff The mobile internet, launched amid great fanfare, falls far short of scientists' needs and expectations. Howy argues that it's time for a rethink. Howy Jacobs EMBO reports (2013), 14, 847; 10.1038/embor.2013.139 Full text | PDF Published online: 30 September 2013 Subject Categories: Technology, Development & Applications Opinion Taming the complexity of large models There are many complex biological models that fit the data perfectly and yet do not reflect the cellular reality. The process of validating a large model should therefore be viewed as an ongoing mission that refines underlying assumptions by improving low-confidence areas or gaps in the model's construction. Matthew Oberhardt and Eytan Ruppin EMBO reports (2013), 14, 848; 10.1038/embor.2013.145 Full text | PDF Published online: 06 September 2013 The Henrietta Lacks legacy grows Now that the NIH has reached an agreement with Henrietta Lacks's family concerning the use of the HeLa cell line, what lessons can we learn about informed consent and the unforeseen use of biological samples? Henry T Greely and Mildred K Cho EMBO reports (2013), 14, 849; 10.1038/embor.2013.148 Full text | PDF Published online: 13 September 2013 Subject Categories: Ethics | Health & Disease Hot off the Press DNGR-ing the dendritic cell lineage A recent groundbreaking study published in Cell provides the first ontogeny of dendritic cell (DC) development using in vivo cell tracking technology. This approach has shed light on several controversies in the DC field. Andreas Schlitzer and Florent Ginhoux EMBO reports (2013), 14, 850 - 851; 10.1038/embor.2013.129 Full text | PDF Published online: 16 August 2013 Subject Categories: Neuroscience Ncking BCR-mediated PI3K activation Nck has been recently shown to be a crucial regulator of B cell receptor (BCR) signaling and link it to PI3K pathways. Notably, this is independent from the known role of Nck in actin reorganization. Jennifer L Cannons, Fang Zhao and Pamela L Schwartzberg EMBO reports (2013), 14, 852 - 853; 10.1038/embor.2013.133 Full text | PDF Published online: 23 August 2013 Subject Categories: Immunology Nucleosome dynamics regulate Neurospora circadian clock How are circadian rhythms epigenetically regulated? Liu and colleagues have discovered a critical circadian clock component, CATP, that regulates rhythmic nucleosome occupancy at the clock gene frequency in Neurospora. Megumi Hatori and Satchidananda Panda EMBO reports (2013), 14, 854 - 855; 10.1038/embor.2013.143 Full text | PDF Published online: 13 September 2013 Subject Categories: Chromatin & Transcription Science & Society Top Organizing a PhD symposium—an inside view Planning a symposium organized by PhD students is a challenging prospect. Insight from the organizers of three such symposia sheds light on the highs and lows of the experience. Markus S Schröder, Dermot Harnett, Benedikt A Minke, Preethy Sasidharan Nair and Committee Member Consortium:  EMBO reports (2013), 14, 856 - 860; 10.1038/embor.2013.147 Full text | PDF Published online: 17 September 2013 Subject Categories: Scientific Training & Careers | Science Infrastructures & Publishing How many scientists does it take to change a paradigm? The scientific process requires a critical attitude towards existing hypotheses and obvious explanations. Teaching this mindset to students is both important and challenging. Neil R Smalheiser EMBO reports (2013), 14, 861 - 865; 10.1038/embor.2013.125 Full text | PDF Published online: 06 September 2013 Subject Categories: Philosophy & History of Science Brothers in arms The horrific injuries and difficult working conditions faced by military medical personnel have forced the military to fund biomedical research to treat soldiers; those new technologies and techniques contribute significantly to civilian medicine. Andrea Rinaldi EMBO reports (2013), 14, 866 - 870; 10.1038/embor.2013.146 Full text | PDF Published online: 13 September 2013 Subject Categories: Health & Disease | Technology, Development & Applications Gene patents and capital investment Will the US Supreme Court's ruling that genes can no longer be patented in the USA boost venture capital investment into biotech and medical startup companies? Howard Wolinsky EMBO reports (2013), 14, 871 - 873; 10.1038/embor.2013.144 Full text | PDF Published online: 13 September 2013 Subject Categories: Economics & Business Review Top The joy of sex pheromones Finding a mate of the right sex, species and optimal fecundity is not easy. Gomez-Diaz and Benton synthesize common principles of sex pheromone production, detection and evoked behaviours from a wide range of species, and single out the unknown molecular and neuronal mechanisms of sex pheromone action. Carolina Gomez-Diaz and Richard Benton EMBO reports (2013), 14, 874 - 883; 10.1038/embor.2013.140 Abstract | Full text | PDF Published online: 13 September 2013 Subject Categories: Neuroscience Scientific Reports Top Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation iRhom2 is essential in macrophages for the maturation of TACE, but how TACE is controlled in other tissues was unknown. This paper shows that TACE activity in all cells depends on iRhom1 and/or iRhom2, demonstrating that iRhoms are essential and specific regulators of multiple signaling pathways. Yonka Christova, Colin Adrain, Paul Bambrough, Ashraf Ibrahim and Matthew Freeman EMBO reports (2013), 14, 884 - 890; 10.1038/embor.2013.128 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 23 August 2013 Subject Categories: Signal Transduction | Cellular Metabolism The phosphatidylinositol-transfer protein Nir2 binds phosphatidic acid and positively regulates phosphoinositide signalling This study shows that the PI-transfer protein Nir2 also binds to phosphatidic acid and that it translocates from the Golgi complex to the plasma membrane in response to growth factor stimulation. At the membrane it positively regulates the production of PI(4,5)P2 and PI(3,4,5)P3 and concomitantly the MAPK and PI3K/AKT signalling pathways. SoHui Kim, Amir Kedan, Merav Marom, Nancy Gavert, Omer Keinan, Michael Selitrennik, Orly Laufman and Sima Lev EMBO reports (2013), 14, 891 - 899; 10.1038/embor.2013.113 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 30 July 2013 Subject Categories: Membranes & Transport | Signal Transduction Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome Cyclic dinucleotides have been recently shown to induce type I interferon secretion. This study shows they also activate the NLRP3 inflammasome to stimulate robust IL-1b secretion through a novel pathway that does not generate mitochondrial ROS. Ali A Abdul-Sater, Ivan Tattoli, Lei Jin, Andrzej Grajkowski, Assaf Levi, Beverly H Koller, Irving C Allen, Serge L Beaucage, Katherine A Fitzgerald, Jenny P -Y Ting, John C Cambier, Stephen E Girardin and Christian Schindler EMBO reports (2013), 14, 900 - 906; 10.1038/embor.2013.132 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 06 September 2013 Subject Categories: Immunology | Microbiology & Pathogens The myotubularin–amphiphysin 2 complex in membrane tubulation and centronuclear myopathies MTM1 and BIN1 are mutated in different forms of centronuclear myopathy. Here, MTM1 is identified as a novel binding partner of BIN1 that enhances BIN1-mediated membrane tubulation. Mutations found in patients induce a conformational change in BIN1 and alter its binding and regulation by MTM1. Barbara Royer, Karim Hnia, Christos Gavriilidis, Hélène Tronchère, Valérie Tosch and Jocelyn Laporte EMBO reports (2013), 14, 907 - 915; 10.1038/embor.2013.119 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 06 August 2013 Subject Categories: Membranes & Transport | Molecular Biology of Disease Messenger RNA is a functional component of a chromatin insulator complex Specific mRNAs associate with the gypsy chromatin insulator complex in Drosophila, and ectopic expression of untranslatable insulator-associated transcripts alters insulator function and localization. This suggests that some mRNAs have a noncoding nuclear function. Leah H Matzat, Ryan K Dale and Elissa P Lei EMBO reports (2013), 14, 916 - 922; 10.1038/embor.2013.118 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 06 August 2013 Subject Categories: Chromatin & Transcription | RNA CATP is a critical component of the Neurospora circadian clock by regulating the nucleosome occupancy rhythm at the frequency locus A circadian histone occupancy rhythm is identified at the promoter of the Neurospora clock gene frq and is regulated by the novel, essential clock component, CATP. CATP promotes histone removal at frq and WCC target gene loci to support circadian gene transcription. Joonseok Cha, Mian Zhou and Yi Liu EMBO reports (2013), 14, 923 - 930; 10.1038/embor.2013.131 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 20 August 2013 Subject Categories: Chromatin & Transcription STAT3 promotes corticospinal remodelling and functional recovery after spinal cord injury Sustained STAT3 activation promotes the remodeling of damaged fibers in the injured spinal cord. It also recruits undamaged fibers from the contralateral site that cross the midline and restore ipsilateral forelimb function. Claudia Lang, Peter M Bradley, Anne Jacobi, Martin Kerschensteiner and Florence M Bareyre EMBO reports (2013), 14, 931 - 937; 10.1038/embor.2013.117 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 09 August 2013 Subject Categories: Neuroscience Structure homology and interaction redundancy for discovering virus–host protein interactions This study describes a new method for the prediction of high-confidence interactions between viral and human proteins based on structure homologies and interactome data which is then used to identify new influenza A virus NS1 functional targets. Benoît de Chassey, Laurène Meyniel-Schicklin, Anne Aublin-Gex, Vincent Navratil, Thibaut Chantier, Patrice André and Vincent Lotteau EMBO reports (2013), 14, 938 - 944; 10.1038/embor.2013.130 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 06 September 2013 Subject Categories: Microbiology & Pathogens | Genomic & Computational Biology Corrections Top Addendum The A to T of historical evidence Howard Wolinsky EMBO reports (2013), 14, 945; 10.1038/embor.2013.127 Full text | PDF Published online: 13 September 2013 Corrigendum Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling Badia Barakat, Liang Yu, Camden Lo, Duc Vu, Elisabetta De Luca, Jason E Cain, Luciano G Martellotto, Shoukat Dedhar, Anthony J Sadler, Die Wang, D Neil Watkins and Gregory E Hannigan EMBO reports (2013), 14, 945; 10.1038/embor.2013.150 Full text | PDF Published online: 03 September 2013 Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to EMBO reports. 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