Drug Discovery@nature.com 25 October 2013

Advertisement Discover Research Partnerships with Boehringer Ingelheim Our research teams know that they can only tackle some of the most important challenges in medicine today if we work together with colleagues outside our organisation. We invite academic institutions, non-profit research centres and external industry partners to help us deliver a better future for patients. Visit http://discoveringtogether.boehringer-ingelheim.com TABLE OF CONTENTS 25 October 2013 News Analysis Research Highlights Research & Reviews Careers Advertisement Frontiers Research Topics enable you and your colleagues to drive your field where you want to take it: Natural Polymers and their drug delivery applications Topic Editors: Ndidi C. Ngwuluka and Nelson A. Ochekpe ¦Submission deadline: 22 Mar 2014 This Research Topic from Frontiers in Pharmacology focuses on the processes and applications of natural polymers in drug delivery.  You can contribute to this Research Topic or even host your own  Nature Reviews Drug Discovery is on Twitter Advertisement Special section on epigenomics The special section on epigenomics in the July 2013 issue of Journal of Human Genetics features review and original articles by top-level epigenetic researchers, and covers various topics of epigenetic research, both basic and clinical.  Take advantage of FREE access to select articles today!    News Top Neurodevice startups target peripheral nervous system doi:10.1038/nbt1013-865 GlaxoSmithKline recently announced their US$50-million Action Potential Venture Capital funding program to support the nascent neuroengineering industry. Full Text Polypill improves adherence but fails to win all scientists' hearts doi:10.1038/nm1013-1192 Rolling a statin, an aspirin, a B vitamin and three blood pressure-lowering drugs into a single so-called polypill could help patients stay on their medication, but more research is needed to see whether this increased adherence leads to fewer cardiovascular events in the long run. Full Text China clampdown on GSK linked to drug costs doi:10.1038/nbt1013-861 China unleashed a crackdown on the pharma industry over accusations of bribery and misconduct, which analysts suggest is intended to ultimately push down drug prices in the Chinese pharma market. Full Text Scripps boosts research coffers by selling reagents to Sigma-Aldrich doi:10.1038/nbt1013-862b Six high-profile laboratories at The Scripps Research Institute have entered an alliance with Sigma-Aldrich with the aim of improving the coordination between reagent discovery and commercialization. Full Text Analysis Top Revving up cGAS doi:10.1038/scibx.2013.1117 Researchers have confirmed the role of cyclic GMP-AMP signaling in the innate immune system, making a case for developing adjuvants that agonize the pathway or antagonists of the pathway to treat autoimmune conditions. Full Text Pharmaceutical forecasting: throwing darts? doi:10.1038/nrd4127 Forecasting of the future commercial value of drugs is a crucial activity that affects many decisions by pharmaceutical companies. However, this analysis indicates that many forecasts are wrong, often substantially. Full Text Research Highlights Top Anticancer drugs: Stapled peptide reactivates p53 doi:10.1038/nrd4133 The stapled α-helical peptide ATSP-7041 - which is a specific dual inhibitor of MDM2 and MDMX - effectively induces p53-dependent apoptosis and inhibits cell proliferation in mouse models of human tumours. Full Text Biotechnology: Rice-derived rotavirus antibody shows promise doi:10.1038/nrd4131 Researchers have genetically engineered rice to produce high yields of a rotavirus-specific antibody fragment in the seeds. This antibody was effective in treating and preventing rotavirus-induced gastrointestinal symptoms in mice. Full Text Neurodegenerative diseases: New kinase targets for Alzheimer's disease doi:10.1038/nrd4132 Two recent studies show that inhibiting kinases involved in the regulation of amyloid precursor protein processing or protein synthesis by eukaryotic translation initiation factor 2α attenuates disease progression in mice. Full Text Research & Reviews Top Considerations for the successful co-development of targeted cancer therapies and companion diagnostics doi:10.1038/nrd4101 The authors discuss issues relating to the co-development of targeted cancer therapies and companion diagnostics that were not covered in depth in the draft guidance released by the US FDA in 2011. They also propose potential strategies that will be useful to mitigate challenges and to help guide the future co-development of drugs and diagnostics. Full Text Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology doi:10.1038/nrc3580 Anaplastic lymphoma kinase (ALK) is commonly altered - through mutation, overexpression or translocation - in many types of cancer, but the role of ALK signalling in mammalian cells and tumours remains enigmatic. What can we learn from model systems? And what progress has been made in targeting this receptor tyrosine kinase? Full Text p11 and its role in depression and therapeutic responses to antidepressants doi:10.1038/nrn3564 Recent studies have shown that the protein p11 (also known as S100A10) has an important role in depression-like behaviour and antidepressant actions. Greengard and colleagues discuss the molecular and cellular mechanisms that may underlie this role. Full Text Macrophages in atherosclerosis: a dynamic balance doi:10.1038/nri3520 In this Review, the authors provide a comprehensive overview of the role of macrophage dynamics in determining the initiation, progression and regression of atherosclerotic inflammation. Understanding the factors that determine the inflammatory state of the plaque may help to identify potential therapeutic targets for plaque regression. Full Text Drug Discovery JOBS of the week Postdoc Position – Cancer Drug Resistance Brigham & Women's Hospital - Harvard Medical School Senior Project Manager Drug Discovery and Development (m / f) Akron Molecules GmbH Full / Associate / Assistant Professor - Pharmaceutics / Drug Delivery / Bioengineering / Nanomedicine Wayne State University Postdoc Fellow– Drug / siRNA delivery nanoparticle-Polymer Chemistry–Molecular Biology University of Hawaii at Hilo, The Daniel K. Inouye College of Pharmacy PhD fellowship with focus on genetic interactions in response to drug treatment Technical University of Denmark (DTU) More Science jobs from Drug Discovery EVENT 6th International Conference on Drug Discovery and Therapy 10.02.14 Dubai More science events from Careers Top Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. 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