Friday, October 25, 2013

Drug Discovery@nature.com 25 October 2013

Drug Discovery

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TABLE OF CONTENTS

25 October 2013

News
Analysis
Research Highlights
Research & Reviews
Careers
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News

Top

Neurodevice startups target peripheral nervous system
doi:10.1038/nbt1013-865
GlaxoSmithKline recently announced their US$50-million Action Potential Venture Capital funding program to support the nascent neuroengineering industry.
Full Text

Polypill improves adherence but fails to win all scientists' hearts
doi:10.1038/nm1013-1192
Rolling a statin, an aspirin, a B vitamin and three blood pressure-lowering drugs into a single so-called polypill could help patients stay on their medication, but more research is needed to see whether this increased adherence leads to fewer cardiovascular events in the long run.
Full Text

China clampdown on GSK linked to drug costs
doi:10.1038/nbt1013-861
China unleashed a crackdown on the pharma industry over accusations of bribery and misconduct, which analysts suggest is intended to ultimately push down drug prices in the Chinese pharma market.
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Scripps boosts research coffers by selling reagents to Sigma-Aldrich
doi:10.1038/nbt1013-862b
Six high-profile laboratories at The Scripps Research Institute have entered an alliance with Sigma-Aldrich with the aim of improving the coordination between reagent discovery and commercialization.
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Analysis

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Revving up cGAS
doi:10.1038/scibx.2013.1117
Researchers have confirmed the role of cyclic GMP-AMP signaling in the innate immune system, making a case for developing adjuvants that agonize the pathway or antagonists of the pathway to treat autoimmune conditions.
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Pharmaceutical forecasting: throwing darts?
doi:10.1038/nrd4127
Forecasting of the future commercial value of drugs is a crucial activity that affects many decisions by pharmaceutical companies. However, this analysis indicates that many forecasts are wrong, often substantially.
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Research Highlights

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Anticancer drugs: Stapled peptide reactivates p53
doi:10.1038/nrd4133
The stapled α-helical peptide ATSP-7041 - which is a specific dual inhibitor of MDM2 and MDMX - effectively induces p53-dependent apoptosis and inhibits cell proliferation in mouse models of human tumours.
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Biotechnology: Rice-derived rotavirus antibody shows promise
doi:10.1038/nrd4131
Researchers have genetically engineered rice to produce high yields of a rotavirus-specific antibody fragment in the seeds. This antibody was effective in treating and preventing rotavirus-induced gastrointestinal symptoms in mice.
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Neurodegenerative diseases: New kinase targets for Alzheimer's disease
doi:10.1038/nrd4132
Two recent studies show that inhibiting kinases involved in the regulation of amyloid precursor protein processing or protein synthesis by eukaryotic translation initiation factor 2α attenuates disease progression in mice.
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Research & Reviews

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Considerations for the successful co-development of targeted cancer therapies and companion diagnostics
doi:10.1038/nrd4101
The authors discuss issues relating to the co-development of targeted cancer therapies and companion diagnostics that were not covered in depth in the draft guidance released by the US FDA in 2011. They also propose potential strategies that will be useful to mitigate challenges and to help guide the future co-development of drugs and diagnostics.
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Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology
doi:10.1038/nrc3580
Anaplastic lymphoma kinase (ALK) is commonly altered - through mutation, overexpression or translocation - in many types of cancer, but the role of ALK signalling in mammalian cells and tumours remains enigmatic. What can we learn from model systems? And what progress has been made in targeting this receptor tyrosine kinase?
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p11 and its role in depression and therapeutic responses to antidepressants
doi:10.1038/nrn3564
Recent studies have shown that the protein p11 (also known as S100A10) has an important role in depression-like behaviour and antidepressant actions. Greengard and colleagues discuss the molecular and cellular mechanisms that may underlie this role.
Full Text

Macrophages in atherosclerosis: a dynamic balance
doi:10.1038/nri3520
In this Review, the authors provide a comprehensive overview of the role of macrophage dynamics in determining the initiation, progression and regression of atherosclerotic inflammation. Understanding the factors that determine the inflammatory state of the plaque may help to identify potential therapeutic targets for plaque regression.
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Drug Discovery
JOBS of the week
Postdoc Position – Cancer Drug Resistance
Brigham & Women's Hospital - Harvard Medical School
Senior Project Manager Drug Discovery and Development (m / f)
Akron Molecules GmbH
Full / Associate / Assistant Professor - Pharmaceutics / Drug Delivery / Bioengineering / Nanomedicine
Wayne State University
Postdoc Fellow– Drug / siRNA delivery nanoparticle-Polymer Chemistry–Molecular Biology
University of Hawaii at Hilo, The Daniel K. Inouye College of Pharmacy
PhD fellowship with focus on genetic interactions in response to drug treatment
Technical University of Denmark (DTU)
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Drug Discovery
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6th International Conference on Drug Discovery and Therapy
10.02.14
Dubai
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Careers

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Career snapshots archive
Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field.
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