SciBX: Science-Business eXchange Contents: September 26 2013, Volume 6 / Issue 37

tr> TABLE OF CONTENTS September 26 2013, Volume 6 / Issue 37 Analysis Cover Story Targets and Mechanisms Tools The Distillery: Therapeutics Cancer Cardiovascular disease Endocrine/metabolic disease Inflammation Neurology The Distillery: Techniques Assays and screens Chemistry Computational models Disease models Imaging Markers Advertisement SciBX is pleased to present: SciBX Summit on Innovation in Drug Discovery and Development 2013 October 29-30, 2013 The Colonnade Hotel, Boston, MA, USA  Click here for more information or to register for this conference today! SciBX: Science-Business eXchange Collection on Antibiotic Resistance This special Collection from SciBX: Science-Business eXchange provides an overview of the state of affairs on antibiotic resistance from the scientific, business and regulatory perspectives.  Click here to access the Collection for free! Produced with support from: Cempra Inc., Cubist Pharmaceuticals Inc., Durata Therapeutics Inc., Polyphor Ltd.   Analysis Cover Story Top Anti-CD20 therapy for heart attack Michael J. Haas doi:10.1038/scibx.2013.1015 A multinational team has used anti-CD20 mAbs to treat heart attacks by depleting inflammation-causing CD20+ B cells at the infarct site. The researchers are planning a Phase IIa trial of Rituxan in MI, and at least one biotech with an anti-CD20 antibody is discussing the findings with its pharma partner. Full Text | PDF Targets and Mechanisms Top Two respiratory viruses, one antibody Tracey Baas doi:10.1038/scibx.2013.1016 Humabs and the Institute for Research in Biomedicine have identified an antibody that could be used to prevent as well as treat RSV, thus providing an advantage over the prophylactic Synagis. The mAb also could be effective against metapneumovirus, another common respiratory virus. Full Text | PDF Hedgehog battles Down syndrome Lev Osherovich doi:10.1038/scibx.2013.1017 Researchers at Johns Hopkins have shown that a hedgehog pathway activator could help improve brain development, learning and memory in patients with Down syndrome. The team is trying to narrow the therapeutic window to maximize neuronal response to boosted hedgehog signaling. Full Text | PDF Tools Top Trapping human genes Amy Donner doi:10.1038/scibx.2013.1018 The Research Center for Molecular Medicine of the Austrian Academy of Sciences and Haplogen have generated a library of haploid knockout human cells that allows for the systematic investigation of gene function in vitro. Haplogen is using the library for its drug discovery programs. Full Text | PDF Distillery: Therapeutics Cancer Top K(lysine) acetyltransferase 2B (KAT2B; PCAF) doi:10.1038/scibx.2013.1019 Cell culture and mouse studies suggest inhibiting PCAF could help treat brain cancer by reducing sonic hedgehog homolog (SHH) signaling. Full Text | PDF Dual specificity phosphatase 4 (DUSP4; MKP2); c-jun N-terminal kinase (JNK); MEK doi:10.1038/scibx.2013.1020 In vitro and mouse studies suggest inhibiting MEK and JNK could help treat triple-negative breast cancer by targeting cancer stem cells. Full Text | PDF Alkylglycerone phosphate synthase (AGPS) doi:10.1038/scibx.2013.1021 Studies in patient samples and mice suggest inhibiting AGPS could help treat cancer. Full Text | PDF E1A binding protein p300 (EP300; p300) doi:10.1038/scibx.2013.1022 Studies in mice suggest inhibiting p300 could help treat cancer by promoting antitumor immunity. Full Text | PDF Enhancer of zeste homolog 2 (EZH2); embryonic ectoderm development (EED) doi:10.1038/scibx.2013.1023 In vitro studies suggest inhibiting EZH2-EED interactions could help treat cancer. Full Text | PDF Follistatin-like 1 (FSTL1) doi:10.1038/scibx.2013.1024 Mouse and cell culture studies suggest inhibiting FSTL1 could help prevent cancer metastasis to the bone. Full Text | PDF Lysine-specific demethylase 2 (KDM2); KDM7 doi:10.1038/scibx.2013.1025 In vitro and cell culture studies identified a hydroxamate-based inhibitor of KDM2 and KDM7 that could help treat cancer. Full Text | PDF Fibroblast growth factor receptor 4 (FGFR4; CD334) doi:10.1038/scibx.2013.1026 Cell culture and mouse studies suggest antagonizing FGFR4 could help treat colorectal cancer. Full Text | PDF CXC chemokine receptor 7 (CXCR7) doi:10.1038/scibx.2013.1027 Mouse studies suggest CXCR7-targeting nanobodies could help treat head and neck cancers. Full Text | PDF Hydroxysteroid 3β dehydrogenase 1 (HSD3B1) doi:10.1038/scibx.2013.1028 In vitro and mouse studies suggest inhibiting HSD3B1 could help treat castration-resistant prostate cancer. Full Text | PDF Cardiovascular disease Top CD20; chemokine CC motif ligand 7 (CCL7; MCP3; SCYA6) doi:10.1038/scibx.2013.1029 Human serum and mouse studies suggest antibodies against CD20 could help treat MI. Full Text | PDF Endocrine/metabolic disease Top v-Maf musculoaponeurotic fibrosarcoma oncogene homolog A (MAFA; RIPE3b1); microRNA-204 (miR-204) doi:10.1038/scibx.2013.1030 Mouse and cell culture studies suggest inhibiting miR-204 could help treat diabetes. Full Text | PDF Inflammation Top Aspergillus fumigatus asperamide B doi:10.1038/scibx.2013.1031 In vitro and mouse studies suggest inhibiting asperamide B could help treat asthma triggered by Aspergillus. Full Text | PDF Neurology Top Ryanodine receptor 1 (RyR1); RyR2 doi:10.1038/scibx.2013.1032 Studies in mice suggest ryanodine receptor agonists could be useful for treating AD. Full Text | PDF Retinoblastoma binding protein 4 (RBBP4; RBAP48) doi:10.1038/scibx.2013.1033 Studies in patient samples and mice suggest increasing RBAP48 levels could help treat age-associated memory impairment. Full Text | PDF Calcium calmodulin-dependent protein kinase IIβ (CAMK2B) doi:10.1038/scibx.2013.1034 Rodent studies suggest decreasing CAMK2B activity in the lateral habenula region of the brain could help treat depression. Full Text | PDF Histone deacetylase 6 (HDAC6) doi:10.1038/scibx.2013.1035 In vitro and mouse studies suggest inhibiting HDAC6 in the brain could help treat depression. Full Text | PDF Smoothened (SMO) doi:10.1038/scibx.2013.1036 Mouse studies suggest agonizing SMO could be useful for treating neurodevelopmental deficits in patients with Down syndrome. Full Text | PDF Glutathione peroxidase 1 (GPX1); glutathione peroxidase 3 plasma (GPX3) doi:10.1038/scibx.2013.1037 Yeast and fly studies suggest glutathione peroxidase mimics could be used to treat Huntington's disease. Full Text | PDF Distillery: Techniques Assays and screens Top Highly specific, recombinant antibodies to detect histone H3 trimethylation doi:10.1038/scibx.2013.1038 Antibodies highly specific for H3K4me3 and H3K9me3 could be used to aid epigenetic drug development. Full Text | PDF Chemistry Top Synthesis of simaomicin-α to enable derivatization doi:10.1038/scibx.2013.1039 A method to synthesize the natural compound simaomicin-α could help the development of analogs for use in cancer. Full Text | PDF Computational models Top A computational model to reconstruct network effects of microRNAs and identify targets doi:10.1038/scibx.2013.1040 A computational model that reconstructs dynamic network effects of miRNAs could help identify miRNA targets for drug discovery. Full Text | PDF Disease models Top A doxycycline-inducible serum amyloid A (SAA) transgenic mouse model of systemic amyloidosis doi:10.1038/scibx.2013.1041 Mice expressing a doxycycline-inducible SAA transgene could help model systemic amyloidosis. Full Text | PDF Brain organoids to model microencephaly in vitro doi:10.1038/scibx.2013.1042 Cell culture studies suggest induced pluripotent stem (iPS) cell–derived brain tissue could aid the discovery of therapeutics for neurodevelopmental disorders. Full Text | PDF Collection of haploid human isogeneic cell lines with mutations in individual genes doi:10.1038/scibx.2013.1043 A collection of haploid human isogeneic cell lines with single mutations could be useful for creating new disease models and identifying therapeutic targets. Full Text | PDF Mice with epidermal-specific knockout of epidermal growth factor receptor (Egfr) to model skin toxicity associated with EGFR-targeted cancer therapy doi:10.1038/scibx.2013.1044 Mice with epidermal-specific knockout of Egfr could help model skin rashes that develop in patients receiving EGFR inhibitors. Full Text | PDF Imaging Top Monitoring response to preventive therapy in patients with Huntington's disease (HD) using 18F-labeled fluorodeoxyglucose PET (FDG-PET) imaging doi:10.1038/scibx.2013.1045 PET imaging of the brain could help monitor treatment responses in patients with presymptomatic and early symptomatic HD. Full Text | PDF Markers Top Genetic markers of statin-induced myopathy doi:10.1038/scibx.2013.1046 Genetic studies identified SNPs that could help stratify patients based on their risk for statin-induced myopathy. Full Text | PDF Measuring CD8+ T cell tumor infiltration to guide immunotherapy selection doi:10.1038/scibx.2013.1047 Studies in mice and in patient samples suggest measuring CD8+ T cell infiltration of tumors could help identify patients who will respond to immunotherapies. Full Text | PDF Single lipid vesicle assay to measure hydrolysis of disease-associated phospholipids doi:10.1038/scibx.2013.1048 An assay using single vesicles to measure phospholipid hydrolysis could be used to identify and quantify disease-associated biomarkers. Full Text | PDF Top Advertisement Nature Publishing Group and Relay Technology Management present: The Epigenetics Target Explorer  Click here to access this free online tool and the accompanying article in Nature Reviews Drug Discovery.

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