Nature Reviews Immunology Contents October 2013 Volume 13 Number 10 pp 703-769

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TABLE OF CONTENTS
October 2013 Volume 13 Number 10		Advertisement
Impact Factor 33.129 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Autophagy in infection, inflammation and immunity Vojo Deretic, Tatsuya Saitoh & Shizuo Akira	Watch 126 sessions from the leading infectious diseases and antimicrobial agents conference, ICAAC 2013. Presentations cover antimicrobial resistance, vaccine development, immunology, microbial pathogenesis, laboratory diagnostics, clinical trials, and more. Earn AMA PRA Category 1 CreditsTM, view abstracts, and tour the iPoster Hall. www.icaaconline.com
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RESEARCH HIGHLIGHTS Top Dendritic cells: Tracing the origins of cDCs p703 | doi:10.1038/nri3541 Lineage tracing on the basis of DNGR1 expression history defines cells of the conventional DC lineage. PDF Asthma and allergy: A fibrinogen root to airway inflammation p704 | doi:10.1038/nri3538 TLR4 activation by fibrinogen cleavage products may contribute to allergic airway inflammation. PDF Pattern recognition receptors: DNA damage drives detection p704 | doi:10.1038/nri3539 Oxidative damage to self and foreign DNA potentiates its detection by the innate immune system. PDF Mucosal immunology: Air miles for T cells p705 | doi:10.1038/nri3537 Lung dendritic cells imprint CD4+ T cells with lung-homing and gut-homing receptors. PDF Neuroimmunology: Pain — blame it on the bug, eh? p706 | doi:10.1038/nri3533 Pain associated with acute bacterial infection is not secondary to immune activation but is directly induced by bacteria themselves. PDF Macrophages: Metabolic master prompts a change of tack p706 | doi:10.1038/nri3542 The metabolic regulator AMPK controls macrophage skewing during muscle repair. PDF B cell development: A window of opportunity p707 | doi:10.1038/nri3540 Early development of B cells can occur in the gut in response to resident microorganisms. PDF IN BRIEF Signalling: NF-κB signalosomes on the ER | Reproductive immunology: How NK cells affect pregnancy outcome | Immune regulation: IL-27 induces immunosuppressive DCs PDF Immunology JOBS of the week Faculty Position in Virology Department of Microbiology-Immunology Northwestern University Tenure - Track Faculty Position in Immunology University of Massachusetts Tenure-Track Faculty Positions in the Department of Biochemistry, Microbiology and Immunology University of Ottawa, Faculty of Medicine Postdoc in Cancer Immunology, Harvard Medical School Dana-Farber Cancer Institute / Harvard Medical School Postdoctoral Fellowship in Retroviral Immunology National Institute of Allergy & Infectious Diseases (NIAID) More Science jobs from Immunology EVENT Tumor Immunology and Immunotherapy 28.10.-01.11.2013 Suzhou, China More science events from
REVIEWS		Top
Macrophages in atherosclerosis: a dynamic balance Kathryn J. Moore, Frederick J. Sheedy & Edward A. Fisher p709 | doi:10.1038/nri3520 In this Review, the authors provide a comprehensive overview of the role of macrophage dynamics in determining the initiation, progression and regression of atherosclerotic inflammation. Understanding the factors that determine the inflammatory state of the plaque may help to identify potential therapeutic targets for plaque regression. Abstract | Full Text | PDF
Autophagy in infection, inflammation and immunity Vojo Deretic, Tatsuya Saitoh & Shizuo Akira p722 | doi:10.1038/nri3532 It is increasingly understood that autophagy is an ancient defence mechanism that has become incorporated into numerous immunological pathways. As discussed in this Review, its immunological roles include the elimination of microorganisms, the control of inflammation, the regulation of antigen presentation and lymphocyte homeostasis, and the secretion of immune mediators. Abstract | Full Text | PDF
The immune system and kidney disease: basic concepts and clinical implications Christian Kurts, Ulf Panzer, Hans-Joachim Anders & Andrew J. Rees p738 | doi:10.1038/nri3523 Chronic kidney disease affects approximately 10% of the Western population. Recent studies have elucidated some of the immune mechanisms that contribute to kidney injury and disease, which are described in this Review. In addition, the contribution of the kidneys to immune homeostasis and the effects of kidney failure on systemic immune functions are discussed. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
INNOVATION Tracking immune cells in vivo using magnetic resonance imaging Eric T. Ahrens & Jeff W. M. Bulte p755 | doi:10.1038/nri3531 This Innovation article describes the development of magnetic resonance imaging (MRI) methods for image-guided immune cell delivery and for the visualization of immune cell homing and engraftment, inflammation, cell physiology and gene expression. Abstract | Full Text | PDF
ESSAY The speed of change: towards a discontinuity theory of immunity? Thomas Pradeu, Sébastien Jaeger & Eric Vivier p764 | doi:10.1038/nri3521 Here, the authors present a new theoretical framework — the discontinuity theory — to account for how the immune system generates an appropriate immune response to any perceived disturbance. On the the basis of this theory, the authors present a mathematical model and provide examples to explain how this model can account for diverse immune responses. Abstract | Full Text | PDF
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*2012 Journal Citation Report (Thomson Reuters, 2013)

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