Nature Review Cancer contents October 2013 Volume 13 Number 10 pp 679-752

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TABLE OF CONTENTS
October 2013 Volume 13 Number 10		Advertisement
Impact Factor 35 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology Bengt Hallberg & Ruth H. Palmer	New CLARIOstar® with Triple Technology The CLARIOstar® multimode microplate reader outperforms conventional instruments with triple technology - LVF Monochromators, filters, and an ultra-fast spectrometer ensure no compromise on flexibility or sensitivity. With the CLARIOstar from BMG LABTECH, anything is possible. Any wavelength. Any bandwidth. Any assay. Learn more at www.bmglabtech.com.
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RESEARCH HIGHLIGHTS Top DNA damage: Running in parallel p679 | doi:10.1038/nrc3607 Simon Boulton and colleagues have found that the 3′-5′ superfamily 2 helicase HELQ is important to prevent germ cell attrition and tumour development in mice. PDF Epigenetics: Showing a more sensitive side p680 | doi:10.1038/nrc3605 Leandro Cerchietti, Ari Melnick and colleagues present evidence that DNA methyltransferase inhibitors (DNMTIs) might be one route through which to improve the outcome for patients with diffuse large B cell lymphoma who have a high risk of relapse. PDF IN THE NEWS Education is key p680 | doi:10.1038/nrc3609 Two new studies have highlighted the lack of understanding many women have about their own breast cancer risk and treatment. PDF Genomics: Mutator catalogues p681 | doi:10.1038/nrc3608 Three papers assess the mutational landscapes of human tumours, and all three find evidence for a role of APOBECs. PDF Signalling: Keeping TABs on p53 p682 | doi:10.1038/nrc3600 This paper shows that apoptosis induced by cisplatin relies on signals that involve MDM2, MDMX, p53, NOXA and TAB1. PDF Mouse models: Novel in vivo RNAi screen in mice p682 | doi:10.1038/nrc3604 A novel in vivo genome-wide RNAi screening method in mice provides insights into the biology of skin growth and skin carcinogenesis. PDF Signalling: Seeing the big picture p683 | doi:10.1038/nrc3602 Two recent papers have uncovered important roles for the receptor tyrosine kinase (RTK) AXL in both resistance to inhibitors of the ERBB family of RTKs and inflammation-induced tumorigenesis. PDF Cancer JOBS of the week Postdoctoral fellowship in Cancer Biology University of California San Francisco (UCSF) - Müschen Lab Postdoctoral fellow in Epigenetics and Cancer Biology at Boston Univeristy School of Medicine Boston University Faculty Positions in Cancer Biology / Genetics OMRF Postdoc in Cancer Immunology, Harvard Medical School Dana-Farber Cancer Institute / Harvard Medical School Tenure Track Faculty Positions Cancer Biology Memorial Sloan-Kettering Cancer Center More Science jobs from Cancer EVENT The Translational Impact of Model Organisms in Cancer 05.11.13 San Diego, USA More science events from
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REVIEWS		Top
Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology Bengt Hallberg & Ruth H. Palmer p685 | doi:10.1038/nrc3580 Anaplastic lymphoma kinase (ALK) is commonly altered — through mutation, overexpression or translocation — in many types of cancer, but the role of ALK signalling in mammalian cells and tumours remains enigmatic. What can we learn from model systems? And what progress has been made in targeting this receptor tyrosine kinase? Abstract | Full Text | PDF
Krüppel-like factors in cancer Marie-Pier Tetreault, Yizeng Yang & Jonathan P. Katz p701 | doi:10.1038/nrc3582 Krüppel-like factor (KLF) transcriptional regulators have diverse functions in many cancer-relevant processes. This Review discusses the context-dependent roles for KLFs in different cancers and identifies key questions for the field. Abstract | Full Text | PDF | Supplementary information
Cancer drug resistance: an evolving paradigm Caitriona Holohan, Sandra Van Schaeybroeck, Daniel B. Longley & Patrick G. Johnston p714 | doi:10.1038/nrc3599 This Review discusses mechanisms of resistance to 'classical' cytotoxic chemotherapeutics and molecularly targeted therapies, which share many features. It is hoped that an improved understanding of the molecular basis of resistance will lead to rational drug combinations and predictive biomarkers. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Unravelling cancer stem cell potential Benjamin Beck & Cédric Blanpain p727 | doi:10.1038/nrc3597 What can we learn about cancer stem cells and tumour tissue hierarchy from what we know about stem cells? Read this Opinion article to find out how our knowledge of normal stem cells applies to cancer stem cells in solid tumours. Abstract | Full Text | PDF
TIMELINE History of myeloid-derived suppressor cells James E. Talmadge & Dmitry I. Gabrilovich p739 | doi:10.1038/nrc3581 Myeloid-derived suppressor cells (MDSCs) remain steeped in mystery and controversy — how do we identify them? How are they recruited to the tumour microenvironment? How do they suppress antitumour immunity? This Timeline article discusses the discovery of MDSCs and what we know now — and need to know in the future — about the role of MDSCs in cancer biology. Abstract | Full Text | PDF
Corrigendum: The DREAM complex: master coordinator of cell cycle-dependent gene expression Subhashini Sadasivam & James A. DeCaprio p752 | doi:10.1038/nrc3598 Full Text | PDF
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*2012 Journal Citation Report (Thomson Reuters, 2013)

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