Laboratory Investigation - Table of Contents alert Volume 93 Issue 10

TABLE OF CONTENTS Volume 93, Issue 10 (October 2013) In this issue Inside LI Research Articles Corrigenda Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Inside LI Top Inside Lab Invest 2013 93: 1066-1067; 10.1038/labinvest.2013.109 Full Text Research Articles Top ORAL, GASTROINTESTINAL, HEPATIC AND PANCREATIC SYSTEMS The pathological significance of Notch1 in oral squamous cell carcinoma Notch signaling is upregulated in human oral squamous cell carcinoma (OSCC) and is associated with proliferation and invasion of OSCC cells. The inactivation of Notch signaling with a γ-secretase inhibitor prevents cell proliferation and TNF-α-dependent invasion of OSCC cells. These results suggest that γ-secretase inhibitors could be useful for treatment of patients with OSCC. Ryoji Yoshida, Masashi Nagata, Hideki Nakayama, Kanako Niimori-Kita, Wael Hassan, Takuji Tanaka, Masanori Shinohara and Takaaki Ito 2013 93: 1068-1081; advance online publication, August 12, 2013; 10.1038/labinvest.2013.95 Abstract | Full Text Osteopontin delays resolution of liver fibrosis Osteopontin knockout (Opn-/-) mice show faster resolution from chronic fibrosis than wild type mice. Opn-/- mice have fewer activated hepatic stellate cells, less tissue inhibitor of metalloproteinase-1, and less collagen-I than wild type mice during resolution. This study shows that OPN delays liver fibrosis resolution due to sustained collagen-I deposition, suggesting that inhibition of OPN could be an effective therapeutic strategy for liver fibrosis. Tung-Ming Leung, Xiaodong Wang, Naoto Kitamura, Maria I Fiel and Natalia Nieto 2013 93: 1082-1089; advance online publication, September 2, 2013; 10.1038/labinvest.2013.104 Abstract | Full Text BREAST, SKIN, SOFT TISSUE AND BONE Characterization of Wnt/β-catenin signaling in rhabdomyosarcoma Canonical Wnt/β-catenin signaling is active in myogenesis, and its dysregulation has been shown to facilitate tumor invasion and metastasis. This study shows that the central regulatory components of Wnt/β-catenin signaling are expressed in rhabdomyosarcoma and that the pathway is functionally active in a significant subset of rhabdomyosarcoma tumors. Therefore, Wnt/β-catenin signaling might represent a novel therapeutic target for this malignant pediatric tumor. Srinivas R Annavarapu, Samantha Cialfi, Carlo Dominici, George K Kokai, Stefania Uccini, Simona Ceccarelli, Heather P McDowell and Timothy R Helliwell 2013 93: 1090-1099; advance online publication, September 2, 2013; 10.1038/labinvest.2013.97 Abstract | Full Text New chondrosarcoma cell lines and mouse models to study the link between chondrogenesis and chemoresistance Two new cell lines were established from chondrosarcoma biopsies. The cell lines harbor mutations in IDH1/2 (isocitrate dehydrogenases) and TP53 (p53), a deletion at the CDKN2A locus, and/or MDM2 (a p53 inhibitor) amplification. When cultured in chondrogenic 3D pellets, the cell lines are able to produce a hyaline cartilaginous matrix which impairs diffusion of mafosfamide and doxorubicin. These results indicate a mechanism by which cells with these genetic abnormalities may contribute to chemoresistance in patients with chondrosarcoma. David Monderer, Alexandrine Luseau, Amélie Bellec, Emmanuelle David, Stéphanie Ponsolle, Soraya Saiagh, Sylvain Bercegeay, Philippe Piloquet, Marc G Denis, Laurence Lodé, Françoise Rédini, Marine Biger, Dominique Heymann, Marie-Françoise Heymann, Ronan Le Bot, François Gouin and Frédéric Blanchard 2013 93: 1100-1114; advance online publication, August 19, 2013; 10.1038/labinvest.2013.101 Abstract | Full Text ANGIOGENESIS, CARDIOVASCULAR AND PULMONARY SYSTEMS Vascular tumors have increased p70 S6-kinase activation and are inhibited by topical rapamycin This study describes the importance of the mammalian target of rapamycin (mTOR) signaling pathways in benign and malignant vascular tumors. The authors show that mTOR may be an important therapeutic target in these tumors because topically-applied rapamycin effectively reduces tumor growth with limited systemic drug absorption. Wa Du, Damien Gerald, Carole A Perruzzi, Paul Rodriguez-Waitkus, Ladan Enayati, Bhuvaneswari Krishnan, Joseph Edmonds, Marcelo L Hochman, Dina C Lev and Thuy L Phung 2013 93: 1115-1127; advance online publication, August 12, 2013; 10.1038/labinvest.2013.98 Abstract | Full Text NOD2 deletion promotes cardiac hypertrophy and fibrosis induced by pressure overload Defining the mechanisms that regulate the pathways involved in the development of cardiac hypertrophy is vital for management of heart disease. The effects of NOD2 deficiency on cardiac hypertrophy induced by aortic banding in mice are revealed in this study. NOD2 inhibits cardiac hypertrophy and fibrosis in response to hypertrophic stimuli in mice by blocking TLR4 and TGF-β/ Smad signaling, and by regulation of pro-fibrotic cytokines and collagen content. Jing Zong, Mohamed Salim, Heng Zhou, Zhou-yan Bian, Jia Dai, Yuan Yuan, Wei Deng, Jie-yu Zhang, Rui Zhang, Qing-qing Wu and Qi-zhu Tang 2013 93: 1128-1136; advance online publication, August 19, 2013; 10.1038/labinvest.2013.99 Abstract | Full Text Enhanced autophagy is required for survival in EGFR-independent EGFR-mutant lung adenocarcinoma cells Activating mutations in the EGFR gene are critical for survival of lung cancer cells. This paper reveals an EGFR-independent mechanism as well. EGFR-mutated lung adenocarcinoma cell lines also harbor a subpopulation of cells with an epithelial-to-mesenchymal transitional phenotype, and these cells can survive under hypoxic conditions in the because of enhanced autophagy. Therefore, targeting autophagy could be an effective additional approach for treatment of lung cancer. Yuji Sakuma, Shoichi Matsukuma, Yoshiyasu Nakamura, Mitsuyo Yoshihara, Shiro Koizume, Hironobu Sekiguchi, Haruhiro Saito, Haruhiko Nakayama, Yoichi Kameda, Tomoyuki Yokose, Sachiko Oguni, Toshiro Niki and Yohei Miyagi 2013 93: 1137-1146; advance online publication, August 12, 2013; 10.1038/labinvest.2013.102 Abstract | Full Text Role of survivin in acute lung injury: epithelial cells of mice and humans This study reveals that survivin, which regulates cell division and survival, is also an important mediator of cytoprotection in noncancerous epithelial cells during acute lung injury. Survivin operates by a mechanism that involves inhibition of apoptosis. Understanding the precise role of survivin in normal lung cells is the first step towards its therapeutic development as an anticancer drug. Yasuhiro Terasaki, Mika Terasaki, Hirokazu Urushiyama, Shinya Nagasaka, Mikiko Takahashi, Shinobu Kunugi, Arimi Ishikawa, Kyoko Wakamatsu, Naomi Kuwahara, Koichi Miyake and Yuh Fukuda 2013 93: 1147-1163; advance online publication, August 26, 2013; 10.1038/labinvest.2013.103 Abstract | Full Text Corrigenda Top Adenosine A2B receptor-mediated VEGF induction promotes diabetic glomerulopathy Angel Cárdenas, Camilo Toledo, Carlos Oyarzún, Angélica Sepúlveda, Claudia Quezada, Elena Guillén-Gómez, Montserrat M Díaz-Encarnación, Marçal Pastor-Anglada and Rody San Martín 2013 93: 1164; 10.1038/labinvest.2013.56 Full Text The inhibitory action of PDCD4 in lipopolysaccharide/D-galactosamine-induced acute liver injury Xiaoyan Wang, Lining Zhang, Zengtao Wei, Xia Zhang, Qi Gao, Yanyan Ma, Xingli Liu, Yang Jiang, Xianglan Liu, Chun Guo and Xiaoyan Wang 2013 93: 1164; 10.1038/labinvest.2013.75 Full Text Gene silencing of EREG mediated by DNA methylation and histone modification in human gastric cancers Jiyeon Yun, Sang-Hyun Song, Jinah Park, Hwang-Phill Kim, Young-Kwang Yoon, Kyung-Hun Lee, Sae-Won Han, Do-Youn Oh, Seock-Ah Im, Yung-Jue Bang and Tae-You Kim 2013 93: 1165; 10.1038/labinvest.2013.100 Full Text Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Laboratory Investigation. 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