The EDGE

Antitumour activity of abiraterone and diethylstilboestrol when administered sequentially to men with castration-resistant prostate cancer

A Omlin, C J Pezaro, S Zaidi, D Lorente, D Mukherji, D Bianchini, R Ferraldeschi, S Sandhu, D Dearnaley, C Parker, N Van As, J S de Bono and G Attard

Br J Cancer 2013 109: 1079-1084; advance online publication, August 8, 2013; 10.1038/bjc.2013.446

A multicenter phase 1 study of PX-866 in combination with docetaxel in patients with advanced solid tumours

D W Bowles, W W Ma, N Senzer, J R Brahmer, A A Adjei, M Davies, A J Lazar, A Vo, S Peterson, L Walker, D Hausman, C M Rudin and A Jimeno

Br J Cancer 2013 109: 1085-1092; advance online publication, August 13, 2013; 10.1038/bjc.2013.474

Critical weight loss is a major prognostic indicator for disease-specific survival in patients with head and neck cancer receiving radiotherapy

J A E Langius, S Bakker, D H F Rietveld, H M Kruizenga, J A Langendijk, P J M Weijs and C R Leemans

Br J Cancer 2013 109: 1093-1099; advance online publication, August 8, 2013; 10.1038/bjc.2013.458

High CC chemokine receptor 7 expression improves postoperative prognosis of lung adenocarcinoma patients

M Itakura, Y Terashima, M Shingyoji, S Yokoi, M Ohira, H Kageyama, Y Matui, Y Yoshida, H Ashinuma, Y Moriya, H Tamura, K Harigaya, K Matushima, T Iizasa, A Nakagawara and H Kimura

Br J Cancer 2013 109: 1100-1108; advance online publication, August 6, 2013; 10.1038/bjc.2013.440

Support vector machine-based nomogram predicts postoperative distant metastasis for patients with oesophageal squamous cell carcinoma

H X Yang, W Feng, J C Wei, T S Zeng, Z D Li, L J Zhang, P Lin, R Z Luo, J H He and J H Fu

Br J Cancer 2013 109: 1109-1116; advance online publication, August 13, 2013; 10.1038/bjc.2013.379

Cetuximab and platinum-based chemoradio- or chemotherapy of patients with epidermal growth factor receptor expressing adenoid cystic carcinoma: a phase II trial

E Hitre, B Budai, Z Takácsi-Nagy, G Rubovszky, E Tóth, É Remenár, C Polgár and I Láng

Br J Cancer 2013 109: 1117-1122; advance online publication, August 13, 2013; 10.1038/bjc.2013.468

High plasma fibrinogen level represents an independent negative prognostic factor regarding cancer-specific, metastasis-free, as well as overall survival in a European cohort of non-metastatic renal cell carcinoma patients

M Pichler, G C Hutterer, T Stojakovic, S Mannweiler, K Pummer and R Zigeuner

Br J Cancer 2013 109: 1123-1129; advance online publication, August 6, 2013; 10.1038/bjc.2013.443

External validation of an online nomogram in patients undergoing radical nephroureterectomy for upper urinary tract urothelial carcinoma

J H Ku, K C Moon, J H Jung, S H Jeong, C Kwak and H H Kim

Br J Cancer 2013 109: 1130-1136; advance online publication, August 15, 2013; 10.1038/bjc.2013.462

Ribosomal s6 protein kinase 4: a prognostic factor for renal cell carcinoma

L Fan, P Li, Z Yin, G Fu, D J Liao, Y Liu, J Zhu, Y Zhang, L Wang, Q Yan, Y Guo, C Shao, G Huang and Z Wang

Br J Cancer 2013 109: 1137-1146; advance online publication, August 13, 2013; 10.1038/bjc.2013.463

Which breast cancer decisions remain non-compliant with guidelines despite the use of computerised decision support?

B Séroussi, C Laouénan, J Gligorov, S Uzan, F Mentré and J Bouaud

Br J Cancer 2013 109: 1147-1156; advance online publication, August 13, 2013; 10.1038/bjc.2013.453

HER2-overexpressing breast cancer: FDG uptake after two cycles of chemotherapy predicts the outcome of neoadjuvant treatment

D Groheux, S Giacchetti, M Hatt, M Marty, L Vercellino, A de Roquancourt, C Cuvier, F Coussy, M Espié and E Hindié

Br J Cancer 2013 109: 1157-1164; advance online publication, August 13, 2013; 10.1038/bjc.2013.469

Clinical relevance of lymph node ratio in breast cancer patients with one to three positive lymph nodes

S I Kim, S-H Cho, J S Lee, H-G Moon, W C Noh, H J Youn, B K Ko and B-W Park

Br J Cancer 2013 109: 1165-1171; advance online publication, August 13, 2013; 10.1038/bjc.2013.465

The value of high adherence to tamoxifen in women with breast cancer: a community-based cohort study

C McCowan, S Wang, A M Thompson, B Makubate and D J Petrie

Br J Cancer 2013 109: 1172-1180; advance online publication, August 15, 2013; 10.1038/bjc.2013.464

Exploring inequalities in access to care and the provision of choice to women seeking breast reconstruction surgery: a qualitative study

S Potter, N Mills, S Cawthorn, S Wilson and J Blazeby

Br J Cancer 2013 109: 1181-1191; advance online publication, August 8, 2013; 10.1038/bjc.2013.461

Celebrities and screening: a measurable impact on high-grade cervical neoplasia diagnosis from the ‘Jade Goody effect’ in the UK

G M Casey, B Morris, M Burnell, A Parberry, N Singh and A N Rosenthal

Br J Cancer 2013 109: 1192-1197; advance online publication, August 20, 2013; 10.1038/bjc.2013.444

Translational Therapeutics

Interferon-β gene-modified human bone marrow mesenchymal stem cells attenuate hepatocellular carcinoma through inhibiting AKT/FOXO3a pathway

C Xie, D-Y Xie, B-L Lin, G-L Zhang, P-P Wang, L Peng and Z-L Gao

Br J Cancer 2013 109: 1198-1205; advance online publication, July 25, 2013; 10.1038/bjc.2013.422

The antibody-based targeted delivery of TNF in combination with doxorubicin eradicates sarcomas in mice and confers protective immunity

T Hemmerle, P Probst, L Giovannoni, A J Green, T Meyer and D Neri

Br J Cancer 2013 109: 1206-1213; advance online publication, July 25, 2013; 10.1038/bjc.2013.421

Src kinases in chondrosarcoma chemoresistance and migration: dasatinib sensitises to doxorubicin in TP53 mutant cells

J G van Oosterwijk, M A J H van Ruler, I H Briaire-de Bruijn, B Herpers, H Gelderblom, B van de Water and J V M G Bovée

Br J Cancer 2013 109: 1214-1222; advance online publication, August 6, 2013; 10.1038/bjc.2013.451

Molecular Diagnostics

Formation and repair kinetics of Pt-(GpG) DNA adducts in extracted circulating tumour cells and response to platinum treatment

I Nel, T C Gauler, W E Eberhardt, A-C Nickel, M Schuler, J Thomale and A-C Hoffmann

Br J Cancer 2013 109: 1223-1229; advance online publication, August 13, 2013; 10.1038/bjc.2013.419

Changes in tumour vessel density upon treatment with anti-angiogenic agents: relationship with response and resistance to therapy

N S Vasudev, V Goh, J K Juttla, V L Thompson, J M G Larkin, M Gore, P D Nathan and A R Reynolds

Br J Cancer 2013 109: 1230-1242; advance online publication, August 6, 2013; 10.1038/bjc.2013.429

MicroRNA-126 and epidermal growth factor-like domain 7–an angiogenic couple of importance in metastatic colorectal cancer. Results from the Nordic ACT trial

T F Hansen, R dP Christensen, R F Andersen, F B Sørensen, A Johnsson and A Jakobsen

Br J Cancer 2013 109: 1243-1251; advance online publication, August 6, 2013; 10.1038/bjc.2013.448

Proline-rich tyrosine kinase 2 and its phosphorylated form pY881 are novel prognostic markers for non-small-cell lung cancer progression and patients’ overall survival

B-H Kuang, M-Q Zhang, L-H Xu, L-J Hu, H-B Wang, W-F Zhao, Y Du and X Zhang

Br J Cancer 2013 109: 1252-1263; advance online publication, August 6, 2013; 10.1038/bjc.2013.439

Clinical significance of disseminated tumour cells in non-small cell lung cancer

A K Rud, E Borgen, G M Mælandsmo, K Flatmark, H Le, D Josefsen, I Solvoll, C B Schirmer, Å Helland, L Jørgensen, O T Brustugun, Ø Fodstad and K Boye

Br J Cancer 2013 109: 1264-1270; advance online publication, August 13, 2013; 10.1038/bjc.2013.450

The tumour suppressor miR-34c targets MET in prostate cancer cells

Z Hagman, B S Haflidadottir, M Ansari, M Persson, A Bjartell, A Edsjö and Y Ceder

Br J Cancer 2013 109: 1271-1278; advance online publication, August 6, 2013; 10.1038/bjc.2013.449

Effects of platelet-activating factor and its differential regulation by androgens and steroid hormones in prostate cancers

B Xu, L Gao, L Wang, G Tang, M He, Y Yu, X Ni and Y Sun

Br J Cancer 2013 109: 1279-1286; advance online publication, August 15, 2013; 10.1038/bjc.2013.480

Epidemiology

Increased risk of second malignancies in chronic lymphocytic leukaemia patients as compared with follicular lymphoma patients: a Canadian population-based study

S Beiggi, J B Johnston, M D Seftel, M W Pitz, R Kumar, V Banerji, E J Griffith and S B Gibson

Br J Cancer 2013 109: 1287-1290; advance online publication, July 16, 2013; 10.1038/bjc.2013.381

Tubal ligation in relation to menopausal symptoms and breast cancer risk

H B Nichols, D D Baird, L A DeRoo, G E Kissling and D P Sandler

Br J Cancer 2013 109: 1291-1295; advance online publication, August 6, 2013; 10.1038/bjc.2013.433

Prospective validation of the breast cancer risk prediction model BOADICEA and a batch-mode version BOADICEACentre

R J MacInnis, A Bickerstaffe, C Apicella, G S Dite, J G Dowty, K Aujard, K-A Phillips, P Weideman, A Lee, M B Terry, G G Giles, M C Southey, A C Antoniou and J L Hopper

Br J Cancer 2013 109: 1296-1301; advance online publication, August 13, 2013; 10.1038/bjc.2013.382

Comparison of clinicopathologic features and survival in young American women aged 18–39 years in different ethnic groups with breast cancer

P Liu, X Li, E A Mittendorf, J Li, X L Du, J He, Y Ren, J Yang, K K Hunt and M Yi

Br J Cancer 2013 109: 1302-1309; advance online publication, August 1, 2013; 10.1038/bjc.2013.387

Weight change in adulthood and risk of postmenopausal breast cancer: the HUNT study of Norway

M D K Alsaker, I Janszky, S Opdahl, L J Vatten and P R Romundstad

Br J Cancer 2013 109: 1310-1317; advance online publication, July 23, 2013; 10.1038/bjc.2013.403

Cancer of unknown primary: a population-based analysis of temporal change and socioeconomic disparities

D Urban, A Rao, M Bressel, Y R Lawrence and L Mileshkin

Br J Cancer 2013 109: 1318-1324; advance online publication, July 16, 2013; 10.1038/bjc.2013.386

The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis

B Lajin and A Alachkar

Br J Cancer 2013 109: 1325-1337; advance online publication, July 16, 2013; 10.1038/bjc.2013.357

Do metastatic colorectal cancer patients who present with late relapse after curative surgery have a better survival?

V T Broadbridge, C S Karapetis, C Beeke, R J Woodman, R Padbury, G Maddern, S W Kim, D Roder, P Hakendorf and T J Price

Br J Cancer 2013 109: 1338-1343; advance online publication, July 16, 2013; 10.1038/bjc.2013.388

The association of coffee intake with liver cancer incidence and chronic liver disease mortality in male smokers

G Y Lai, S J Weinstein, D Albanes, P R Taylor, K A McGlynn, J Virtamo, R Sinha and N D Freedman

Br J Cancer 2013 109: 1344-1351; advance online publication, July 23, 2013; 10.1038/bjc.2013.405

Prospective study of the relationship between coffee and tea with colorectal cancer risk: The PLCO Cancer Screening Trial

C Dominianni, W-Y Huang, S Berndt, R B Hayes and J Ahn

Br J Cancer 2013 109: 1352-1359; advance online publication, August 1, 2013; 10.1038/bjc.2013.434

The role of Mediterranean diet on the risk of pancreatic cancer

C Bosetti, F Turati, A Dal Pont, M Ferraroni, J Polesel, E Negri, D Serraino, R Talamini, C La Vecchia and M P Zeegers

Br J Cancer 2013 109: 1360-1366; advance online publication, August 8, 2013; 10.1038/bjc.2013.345

Poor oral hygiene and risk of esophageal squamous cell carcinoma in Kashmir

N A Dar, F Islami, G A Bhat, I A Shah, M A Makhdoomi, B Iqbal, R Rafiq, M M Lone, C C Abnet and P Boffetta

Br J Cancer 2013 109: 1367-1372; advance online publication, July 30, 2013; 10.1038/bjc.2013.437

Longitudinal patterns of psychological distress in adult survivors of childhood cancer

T M Brinkman, L Zhu, L K Zeltzer, C J Recklitis, C Kimberg, N Zhang, A C Muriel, M Stovall, D K Srivastava, L L Robison and K R Krull

Br J Cancer 2013 109: 1373-1381; advance online publication, July 23, 2013; 10.1038/bjc.2013.428

Letters to the Editor

Comment: childhood leukaemia and power lines – the Geocap study: is proximity an appropriate MF exposure surrogate?

M Bonnet-Belfais, J Lambrozo and A Aurengo

Br J Cancer 2013 109: 1382-1383; advance online publication, August 15, 2013; 10.1038/bjc.2013.423

Reply: Comment on ‘Childhood leukaemia close to high-voltage power lines – the Geocap study, 2002–2007’ – Is proximity an appropriate MF exposure surrogate?

J Clavel, C Sermage-Faure, C Demoury, J Rudant, S Goujon-Bellec, A Guyot-Goubin, F Deschamps and D Hémon

Br J Cancer 2013 109: 1383-1384; advance online publication, August 15, 2013; 10.1038/bjc.2013.424

Comment on ‘Childhood leukaemia close to high-voltage power lines – the Geocap study, 2002–2007’ – Odds ratio and confidence interval

M T Magaña Torres and J R Gonzalez Garcia

Br J Cancer 2013 109: 1384-1385; advance online publication, August 15, 2013; 10.1038/bjc.2013.425

Reply: Comment on ‘Childhood leukaemia close to high-voltage power lines – the Geocap study, 2002–2007’ – Odds ratio and confidence interval

J Clavel and D Hémon

Br J Cancer 2013 109: 1385; advance online publication, August 15, 2013; 10.1038/bjc.2013.426

Comment on ‘Allergy and acute leukaemia in children with Down syndrome: a population study. Report from the Mexican Inter Institutional Group for the Identification of the Causes of Childhood Leukaemia (MIGICCL)’ – Is increased surveillance by hypersensitive immune system a reality or myth?

Z Aryan and N Rezaei

Br J Cancer 2013 109: 1386-1388; advance online publication, August 1, 2013; 10.1038/bjc.2013.435

Reply: Comment on ‘Allergy and acute leukaemia in children with Down syndrome: a population study. Report from the Mexican Inter-Institutional Group for the Identification of the Causes of Childhood Leukaemia (MIGICCL)’ – A reality or myth or two viewpoints about the association between allergies and acute leukaemia in Down syndrome children

J C Núñez-Enríquez, A Fajardo-Gutiérrez, E P Buchán-Durán, E Jiménez-Hernández and J M Mejía-Aranguré

Br J Cancer 2013 109: 1388-1390; advance online publication, August 1, 2013; 10.1038/bjc.2013.436