EMBO Reports - Table of Contents alert Volume 14 Issue 8, pp 659-747

TABLE OF CONTENTS August 2013 | Volume 14, Issue 8 Upfront Science & Society Review Scientific Reports Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement Latest online: the molecular basis for Parkinson’s disease Compact Parkin only: insights into the structure of an autoinhibited ubiquitin ligase R Andrew Byrd and Allan M Weissman Structure of the human Parkin ligase domain in an autoinhibited state Tobias Wauer and David Komander   Upfront Top Editorial Island of hope Two years on from the terrorist massacre in Norway, Howy argues that we still need to rebut the pernicious ideology that motivated the perpetrator. Howy Jacobs EMBO reports (2013), 14, 659; 10.1038/embor.2013.91 Full text | PDF Published online: 01 August 2013 Subject Categories: Philosophy & History of Science Opinion The sacredness of human life Christian De Duve's decision to voluntarily pass away gives us a pause to consider the value and meaning of death. Biologists have much to contribute to the discussion of dying with dignity. Ladislav Kováč EMBO reports (2013), 14, 660; 10.1038/embor.2013.98 Full text | PDF Published online: 12 July 2013 Subject Categories: Philosophy & History of Science Why haven't we made an efficacious vaccine for malaria? The malaria parasite has an extraordinary ability to evade the immune system, which may explain the failure of malaria vaccines to date. It is high time to think seriously of new treatments for this disease. Michelle N Wykes EMBO reports (2013), 14, 661; 10.1038/embor.2013.103 Full text | PDF Published online: 12 July 2013 Subject Categories: Immunology | Microbiology & Pathogens Endless paces of degeneration—applying comparative genomics to study evolution's moulding of longevity Why do mice and humans have such different lifespans? Genome sequencing efforts are allowing researchers to pick apart the genetic foundations of longevity, with some promising results beginning to emerge. João Pedro de Magalhães and Michael Kean EMBO reports (2013), 14, 661 - 662; 10.1038/embor.2013.96 Full text | PDF Published online: 12 July 2013 Subject Categories: Genomic & Computational Biology | Cellular Metabolism | Development Hot off the Press Nuclear microbiology—bacterial assault on the nucleolus New research by Ting Li, Feng Shao and colleagues shows that bacterial pathogens, such as Legionella and Burkholderia spp., can hijack the nucleolus by secreting SET-domain effectors that target and modify rDNA chromatin. Hélène Bierne EMBO reports (2013), 14, 663 - 664; 10.1038/embor.2013.105 Full text | PDF Published online: 16 July 2013 Subject Categories: Microbiology & Pathogens | Molecular Biology of Disease DNA repair pathway choice—a PTIP of the hat to 53BP1 In the June issue of Cell, Nussenzweig and colleagues identify PTIP/PAXIP as a 53BP1 effector protein in the regulatory network that controls DSB repair pathway choice. Cristina Escribano-Diaz and Daniel Durocher EMBO reports (2013), 14, 665 - 666; 10.1038/embor.2013.99 Full text | PDF Published online: 12 July 2013 Subject Categories: Genome Stability & Dynamics Meeting Point Bacterial regulatory networks—from self-organizing molecules to cell shape and patterns in bacterial communities The ESF–EMBO Conference on ‘Bacterial Networks’ was held in March, 2013. It brought together molecular microbiologists, bacteral systems biologists and synthetic biologists to discuss the architecture, function and dynamics of regulatory networks in bacteria. Regine Hengge and Victor Sourjik EMBO reports (2013), 14, 667 - 669; 10.1038/embor.2013.93 Full text | PDF Published online: 12 July 2013 Subject Categories: Microbiology & Pathogens | Signal Transduction | Cellular Metabolism Correspondence Comment on ‘Howyland’ Ivan Couée EMBO reports (2013), 14, 670; 10.1038/embor.2013.100 Full text | PDF Published online: 12 July 2013 Subject Categories: Science Policy & Funding Science & Society Top Society and GMOs—chicken and egg? The debate about GM crops in Europe holds valuable lessons about risk management and risk communication. These lessons will be helpful for the upcoming debate on GM animals. Núria Vàzquez-Salat and Louis-Marie Houdebine EMBO reports (2013), 14, 671 - 674; 10.1038/embor.2013.101 Full text | PDF Published online: 16 July 2013 Subject Categories: Evolution, Environment & Agriculture | Genetically Modified Organisms Lost in translation Some view social constructivism as a threat to the unique objectivity of science in describing the world. But social constructivism merely observes the process of science and can offer ways for science to regain public esteem. Monica Racovita EMBO reports (2013), 14, 675 - 678; 10.1038/embor.2013.90 Full text | PDF Published online: 16 July 2013 Subject Categories: Philosophy & History of Science The A to T of historical evidence Geneticists and historians collaborated recently to identify the remains of King Richard III of England, found buried under a car park. Genetics has many more contributions to make to history, but scientists and historians must learn to speak each other's languages. Howard Wolinsky EMBO reports (2013), 14, 679 - 682; 10.1038/embor.2013.97 Full text | PDF Published online: 12 July 2013 Subject Categories: Technology, Development & Applications The secret garden's gardeners The role of the microbial fauna in our gut for health and well-being is undisputed. Now, scientists are discovering that gut viruses also play a crucial role in modulating our risk for a wide range of diseases. Philip Hunter EMBO reports (2013), 14, 683 - 685; 10.1038/embor.2013.104 Full text | PDF Published online: 16 July 2013 Subject Categories: Health & Disease Review Top Cancer heterogeneity—a multifaceted view In this review Jan Paul Medema and colleagues discuss the differences associated with organ-specific cancer subtypes and the factors that contribute to intra-tumour heterogeneity. Understanding tumour heterogeneity is crucial for the development of more rational anti-cancer treatments. Felipe De Sousa E Melo, Louis Vermeulen, Evelyn Fessler and Jan Paul Medema EMBO reports (2013), 14, 686 - 695; 10.1038/embor.2013.92 Abstract | Full text | PDF Published online: 12 July 2013 Subject Categories: Molecular Evolution | Signal Transduction | Molecular Biology of Disease Scientific Reports Top Adherens junctions determine the apical position of the midbody during follicular epithelial cell division This study reports that asymmetric cytokinesis in epithelial cells does not result from intrinsic polarization of contractile ring components. Instead, it relies on the asymmetric distribution of adherens junction proteins, which determines the apical position of the midbody. Eurico Morais-de-Sá and Claudio Sunkel EMBO reports (2013), 14, 696 - 703; 10.1038/embor.2013.85 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 18 June 2013 Subject Categories: Cell & Tissue Architecture | Cell Cycle The chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres The chromatin remodelling complex NoRC silences rRNA genes. This study shows that NoRC also establishes repressive heterochromatin at centromeres and telomeres, and thereby preserves the structural and functional integrity of these loci. Anna Postepska-Igielska, Damir Krunic, Nina Schmitt, Karin M Greulich-Bode, Petra Boukamp and Ingrid Grummt EMBO reports (2013), 14, 704 - 710; 10.1038/embor.2013.87 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 25 June 2013 Subject Categories: Chromatin & Transcription | Genome Stability & Dynamics An alternative beads-on-a-string chromatin architecture in Thermococcus kodakarensis Chromatin-sequencing reveals an archaeal histone-protein based chromatin architecture, in which the beads-on-a-string vary in size and associate with DNA lengths of 30bp or multiples thereof. Hugo Maruyama, Janet C Harwood, Karen M Moore, Konrad Paszkiewicz, Samuel C Durley, Hisanori Fukushima, Haruyuki Atomi, Kunio Takeyasu and Nicholas A Kent EMBO reports (2013), 14, 711 - 717; 10.1038/embor.2013.94 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 09 July 2013 Subject Categories: Chromatin & Transcription | Molecular Evolution Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling This study identifies a novel role for Wnk kinases in canonical Wnt signalling that appears to be conserved from Drosophila to humans. Ekatherina Serysheva, Hebist Berhane, Luca Grumolato, Kubilay Demir, Sophie Balmer, Maxime Bodak, Michael Boutros, Stuart Aaronson, Marek Mlodzik and Andreas Jenny EMBO reports (2013), 14, 718 - 725; 10.1038/embor.2013.88 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 25 June 2013 Subject Categories: Development | Development Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes  EMBO Open These study shows that A3ARs aggregate in polarized immunomodulatory microdomains on human neutrophils and induce filipodia-like projections that tether and 'reel-in' pathogens, increasing phagocytic efficiency. Ross Corriden, Tim Self, Kathryn Akong-Moore, Victor Nizet, Barrie Kellam, Stephen J Briddon and Stephen J Hill EMBO reports (2013), 14, 726 - 732; 10.1038/embor.2013.89 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 02 July 2013 Subject Categories: Immunology | Microbiology & Pathogens | Signal Transduction SET-domain bacterial effectors target heterochromatin protein 1 to activate host rDNA transcription This study shows that intracellular bacterial pathogens activate host rDNA transcription through secreted SET-domain-containing bacterial effectors that modify rDNA chromatin. The findings also indicate that activation of rDNA transcription promotes intracellular bacterial survival. Ting Li, Qiuhe Lu, Guolun Wang, Hao Xu, Huanwei Huang, Tao Cai, Biao Kan, Jianning Ge and Feng Shao EMBO reports (2013), 14, 733 - 740; 10.1038/embor.2013.86 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 25 June 2013 Subject Categories: Microbiology & Pathogens | Chromatin & Transcription CCRK depletion inhibits glioblastoma cell proliferation in a cilium-dependent manner Glioblastoma cells often lose cilia. This study shows that depletion of CCRK enhances cilia growth and thereby inhibits glioblastoma proliferation, suggesting that some cancer cells gain a growth advantage by actively repressing ciliogenesis. Ying Yang, Niina Roine and Tomi P Mäkelä EMBO reports (2013), 14, 741 - 747; 10.1038/embor.2013.80 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 07 June 2013 Subject Categories: Cell Cycle | Molecular Biology of Disease Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to EMBO reports. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. 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