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TABLE OF CONTENTS
| | 31 July 2013 | Volume 32, Issue 15 |  | | |  |  Have you seen?
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| | | | Advertisement | | | | |  | Have you seen? | Top | |  | |  Compact Parkin only: insights into the structure of an autoinhibited ubiquitin ligase Five recent studies provide long-awaited structural views of the intricate interdomain arrangements that control hybrid RBR family ubiquitin ligases. R Andrew Byrd and Allan M Weissman The EMBO Journal (2013), 32, 2087 - 2089; 10.1038/emboj.2013.158 Abstract | Full text | PDF | Related article Published online: 12 July 2013 | | | |  How two become one: HJURP dimerization drives CENP-A assembly The demonstration that self-association of the CENP-A chaperone HJURP is essential for centromere assembly resolves a paradox in the CENP-A deposition pathway. Dani L Bodor and Lars E T Jansen The EMBO Journal (2013), 32, 2090 - 2092; 10.1038/emboj.2013.150 Abstract | Full text | PDF | Related article | Related article | Related article Published online: 21 June 2013 | | | |  KIF16B delivers for transcytosis Epithelia that natively lack the clathrin adaptor AP-1B recycle basolateral proteins to their apical domain by transcytosis. Although microtubules are required for this process, KIF16B is the first kinesin identified to be involved in transcytosis. Alejo E Rodríguez-Fraticelli, Manuel Galvez-Santisteban and Fernando Martin-Belmonte The EMBO Journal (2013), 32, 2093 - 2095; 10.1038/emboj.2013.153 Abstract | Full text | PDF | Related article Published online: 28 June 2013 | | | |  Enhancer-derived RNAs: ‘spicing up’ transcription programs Functional roles of enhancer-derived RNAs (eRNAs) have so far been enigmatic. Two studies, recently published in Nature, establish the importance of eRNA transcription and reveal unexpected specificity in the regulation of adjacent mRNAs. Aisling M Redmond and Jason S Carroll The EMBO Journal (2013), 32, 2096 - 2098; 10.1038/emboj.2013.151 Abstract | Full text | PDF | Related article | Related article Published online: 21 June 2013 | | Articles | Top | | | |  Structure of the human Parkin ligase domain in an autoinhibited state EMBO Open The complete structural view of a RING-IBR-RING (RBR) ubiquitin ligase domain reveals an unexpected catalytic triad and explains the effects of various Parkin mutations underlying Parkinson’s disease. Tobias Wauer and David Komander The EMBO Journal (2013), 32, 2099 - 2112; 10.1038/emboj.2013.125 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 31 May 2013 | | | |  Dimerization of the CENP-A assembly factor HJURP is required for centromeric nucleosome deposition Whether centromeric nucleosomes are hemisomes, or consist of canonical histone octamers with two CENP-A subunits, is still unresolved. Obligatory dimerization of the CENP-A assembly chaperone HJURP now provides support for the latter possibility. Ewelina Zasadzińska, Meghan C Barnhart-Dailey, P Henning J L Kuich and Daniel R Foltz The EMBO Journal (2013), 32, 2113 - 2124; 10.1038/emboj.2013.142 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 14 June 2013 | | | |  The kinesin KIF16B mediates apical transcytosis of transferrin receptor in AP-1B-deficient epithelia Certain epithelia lack the clathrin adaptor AP-1B and recycle basolateral receptors to the apical membrane by transcytosis. This process involves trafficking into apical recycling endosomes mediated by the kinesin KIF16B and delivery to the apical membrane through Rab11a vesicles. Andres E Perez Bay, Ryan Schreiner, Francesca Mazzoni, Jose M Carvajal-Gonzalez, Diego Gravotta, Emilie Perret, Gullermo Lehmann Mantaras, Yuan-Shan Zhu and Enrique J Rodriguez-Boulan The EMBO Journal (2013), 32, 2125 - 2139; 10.1038/emboj.2013.130 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 07 June 2013 | | | |  Threshold-controlled ubiquitination of the EGFR directs receptor fate EMBO Open The amount of EGF present for binding to its receptor governs an on–off switch of EGFR ubiquitination and hence ligand-controlled non-clathrin-mediated endocytosis and EGFR degradation. Sara Sigismund, Veronica Algisi, Gilda Nappo, Alexia Conte, Roberta Pascolutti, Alessandro Cuomo, Tiziana Bonaldi, Elisabetta Argenzio, Lisette G G C Verhoef, Elena Maspero, Fabrizio Bianchi, Fabrizio Capuani, Andrea Ciliberto, Simona Polo and Pier Paolo Di Fiore The EMBO Journal (2013), 32, 2140 - 2157; 10.1038/emboj.2013.149 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 25 June 2013 | | | |  Functional determinants of the quorum-sensing non-coding RNAs and their roles in target regulation EMBO Open Quorum sensing in bacteria is controlled by five small RNAs, Qrr1–5, which exert post-transcriptional control of 16 novel target genes through four conserved stem-loops with distinct roles in target binding and sRNA stability. Yi Shao, Lihui Feng, Steven T Rutherford, Kai Papenfort and Bonnie L Bassler The EMBO Journal (2013), 32, 2158 - 2171; 10.1038/emboj.2013.155 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 09 July 2013 | | | |  DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation EMBO Open A vertebrate translesion synthesis DNA polymerase broadly contributes to checkpoint-activating primer synthesis at stalled replication forks, a role previously ascribed only to replicative polymerases. Rémy Bétous, Marie-Jeanne Pillaire, Laura Pierini, Siem van der Laan, Bénédicte Recolin, Emma Ohl-Séguy, Caixia Guo, Naoko Niimi, Petr Grúz, Takehiko Nohmi, Errol Friedberg, Christophe Cazaux, Domenico Maiorano and Jean-Sébastien Hoffmann The EMBO Journal (2013), 32, 2172 - 2185; 10.1038/emboj.2013.148 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 25 June 2013 | | | Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. 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