The EMBO Journal - Table of Contents alert Volume 32 Issue 14

TABLE OF CONTENTS 17 July 2013 | Volume 32, Issue 14 Have you seen? Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement EMBO Transparent Process TRANSPARENT - Referee reports published (without attribution) - No confidential comments FAIR - Referee cross-commenting for balanced decisions - Scooping protection during review and revision FAST - <1 week to a first decision and <1 month to complete peer-review - >90% of published manuscripts undergo a single round of revision (taking on average 3 months) - >95% invited revisions are published Have you seen? Top Break the loop, escape the cycle? Berns Pharmaceutical targeting of Wnt/β-catenin signalling blocks stem cell self-renewal and tumour growth, demonstrating oncogene-associated epigenetic hijacking of self-renewal pathways in a mouse model of squamous cell carcinoma. Renée van Amerongen and Anton Berns The EMBO Journal (2013), 32, 1967 - 1969; 10.1038/emboj.2013.137 Abstract | Full text | PDF | Related article Published online: 07 June 2013 Knocking off their Sox: lineage-specific repression by Polycomb in epidermal stem cells Ezh-1 and -2 restrict Merkel cell differentiation via repression of Sox2 and its downstream regulatory targets. Tudorita Tumbar The EMBO Journal (2013), 32, 1970 - 1971; 10.1038/emboj.2013.132 Abstract | Full text | PDF | Related article Published online: 31 May 2013 Think globally, act locally: How bacteria integrate local decisions with their global cellular programme c-di-GMP signalling specificity can be achieved through local concentration of signalling components, which not only act as enzymes to regulate c-di-GMP levels but also as sensors to regulate protein activity. Urs Jenal The EMBO Journal (2013), 32, 1972 - 1974; 10.1038/emboj.2013.140 Abstract | Full text | PDF | Related article Published online: 07 June 2013 Senescent cells spread the word: non-cell autonomous propagation of cellular senescence Oncogene-induced senescence has been thought to operate cell autonomously. New data establish ‘paracrine senescence’ as a mechanism for senescent cells to instruct their environment with consequences for tissue homeostasis. Nilgun Tasdemir and Scott W Lowe The EMBO Journal (2013), 32, 1975 - 1976; 10.1038/emboj.2013.139 Abstract | Full text | PDF | Related article Published online: 18 June 2013 Articles Top Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours Hyperproliferation of tumour-propagating cells in squamous cell carcinoma depends on Wnt/β-catenin signalling, which induces an open chromatin state and expression of self-renewal genes. Peter Wend, Liang Fang, Qionghua Zhu, Jörg H Schipper, Christoph Loddenkemper, Frauke Kosel, Volker Brinkmann, Klaus Eckert, Simone Hindersin, Jane D Holland, Stephan Lehr, Michael Kahn, Ulrike Ziebold and Walter Birchmeier The EMBO Journal (2013), 32, 1977 - 1989; 10.1038/emboj.2013.127 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 04 June 2013 Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells Ezh1/2-mediated repression of the transcription factor Sox2 in epidermal progenitors extends the role of Polycomb proteins in controlling cellular identity beyond ES cells towards tissue-specific stem cells. Evan S Bardot, Victor J Valdes, Jisheng Zhang, Carolina N Perdigoto, Silvia Nicolis, Stephen A Hearn, Jose M Silva and Elena Ezhkova The EMBO Journal (2013), 32, 1990 - 2000; 10.1038/emboj.2013.110 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 14 May 2013 The EAL domain protein YciR acts as a trigger enzyme in a c-di-GMP signalling cascade in E. coli biofilm control  EMBO Open The levels of bacterial biofilm regulator c-di-GMP are controlled in E. coli by two diguanylate cyclase/phosphodiesterase pairs acting sequentially, YegE/YhjH and YdaM/YciR. Interestingly, YciR both degrades c-di-GMP and acts as a ‘trigger enzyme’ regulating YdaM activity through direct physical interaction. Sandra Lindenberg, Gisela Klauck, Christina Pesavento, Eberhard Klauck and Regine Hengge The EMBO Journal (2013), 32, 2001 - 2014; 10.1038/emboj.2013.120 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 24 May 2013 Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles  EMBO Open Bace1 is required for Nrg1 processing for muscle spindle development. Bace1 inhibition leads to loss of motor coordination even in adult mice, suggesting potentially serious side effects for drugs targeting Bace1 as a treatment for Alzheimer’s disease. Cyril Cheret, Michael Willem, Florence R Fricker, Hagen Wende, Annika Wulf-Goldenberg, Sabina Tahirovic, Klaus-Armin Nave, Paul Saftig, Christian Haass, Alistair N Garratt, David L Bennett and Carmen Birchmeier The EMBO Journal (2013), 32, 2015 - 2028; 10.1038/emboj.2013.146 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 21 June 2013 Ultra-deep profiling of alternatively spliced Drosophila Dscam isoforms by circularization-assisted multi-segment sequencing Alternative splicing of the Down syndrome cell adhesion molecule, Dscam, can generate thousands of different isoforms. A novel method is developed that quantitatively profiles Dscam isoform expression revealing dynamic and differential splicing patterns during development. Wei Sun, Xintian You, Andreas Gogol-Döring, Haihuai He, Yoshiaki Kise, Madlen Sohn, Tao Chen, Ansgar Klebes, Dietmar Schmucker and Wei Chen The EMBO Journal (2013), 32, 2029 - 2038; 10.1038/emboj.2013.144 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 21 June 2013 Ral mediates activity-dependent growth of postsynaptic membranes via recruitment of the exocyst Postsynaptic membrane remodelling requires vesicle trafficking. The small GTPase Ral is activated in response to calcium influx and regulates the exocyst complex, therefore providing a link between synaptic activity and membrane trafficking Rita O Teodoro, Gulçin Pekkurnaz, Abdullah Nasser, Misao E Higashi-Kovtun, Maria Balakireva, Ian G McLachlan, Jacques Camonis and Thomas L Schwarz The EMBO Journal (2013), 32, 2039 - 2055; 10.1038/emboj.2013.147 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 28 June 2013 The ALS8 protein VAPB interacts with the ER–Golgi recycling protein YIF1A and regulates membrane delivery into dendrites The Amyotrophic Lateral Sclerosis type 8, ALS8, linked VAPB protein interacts with the ER transmembrane protein YIF1A to regulate intracellular membrane trafficking and dendritic growth. Marijn Kuijpers, Ka Lou Yu, Eva Teuling, Anna Akhmanova, Dick Jaarsma and Casper C Hoogenraad The EMBO Journal (2013), 32, 2056 - 2072; 10.1038/emboj.2013.131 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 04 June 2013 Arabidopsis MSI1 connects LHP1 to PRC2 complexes The Arabidopsis protein MSI1 is an essential component of the Polycomb repressive complex 2, PRC2, and links PRC2 to the polycomb group protein LHP1 to promote the inheritance of H3K27me3 during DNA replication. Maria Derkacheva, Yvonne Steinbach, Thomas Wildhaber, Iva Mozgová, Walid Mahrez, Paolo Nanni, Sylvain Bischof, Wilhelm Gruissem and Lars Hennig The EMBO Journal (2013), 32, 2073 - 2085; 10.1038/emboj.2013.145 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 18 June 2013 Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. In order to do so, please purchase a subscription. 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