Nature Reviews Neuroscience contents August 2013 Volume 14 Number 8 pp 519 - 585

TABLE OF CONTENTS
August 2013 Volume 14 Number 8
Impact Factor 31.673 *	In this issue Research Highlights Reviews Perspectives Correspondence Also this month Article series: Neuroscience and the law  Featured article: Effects of Schedule I drug laws on neuroscience research and treatment innovation David J. Nutt, Leslie A. King & David E. Nichols
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RESEARCH HIGHLIGHTS Top Learning and memory: Locating lost memories p519 | doi:10.1038/nrn3557 Cheng and Ji show that in a mouse model of Alzheimer's disease, new spatial memory formation by hippocampal place cells is disrupted by an inability to encode external environmental information and by dominating internally generated brain activity. PDF Neural development: Breaking before branching p520 | doi:10.1038/nrn3556 A study reveals a signalling pathway in the mouse cortex that immobilizes mitochondria at nascent presynaptic sites in developing axons and thereby promotes terminal axon branching. PDF Attention: Fine-tuning the synaptic signal p520 | doi:10.1038/nrn3558 Attention increases synaptic efficacy and improves signal-to-noise processing at thalamocortical synapses. PDF Synaptic transmission: Short-term consequences for calyces p521 | doi:10.1038/nrn3555 A new study reveals that an interaction between Ca2+/calmodulin and the vesicle-priming protein MUNC13-1 has a crucial role in replenishment of the presynaptic readily releasable pool of vesicles after depletion by high-frequency stimulation. PDF Psychiatric disorders: Repetitive circuits p522 | doi:10.1038/nrn3547 Two studies use optogenetics to explore the contribution of corticostriatal circuit dysfunction to compulsive behaviour. PDF Neurogenesis: A bombshell of a finding p522 | doi:10.1038/nrn3548 A new study provides evidence that around 1,400 dentate gyrus cells are born in the adult human brain every day. PDF IN BRIEF Receptors: Salt attraction | Neurological disorders: Loss of MECP2 bridge in Rett | Neural pathways: Channelling CO2 sensing | Mood disorders: A new target for antidepressant drugs | Neurotransmitter receptors: Splicing up synaptic strength | Sensory processing: Parallel paths | Behavioural neuroscience: Promoting the interspecies divide | Neuronal circuits: Deciphering striatal innervation PDF Neuroscience JOBS of the week Postdoctoral Researcher - Systems Neuroscience University of Utah Department of Neurology Junior Bioinformatician Harvard School of Public Health Project Coordinator at Stockholm Brain Institute and StratNeuro Karolinska Institutet Postdoctoral Fellow The University of Hong Kong More Science jobs from Neuroscience EVENT Annual International Conference on Neuroscience and Neurobiology Research 18.11.13 Bangkok, Thailand More science events from
REVIEWS		Top
Shaping the nervous system: role of the core planar cell polarity genes Fadel Tissir & André M. Goffinet p525 | doi:10.1038/nrn3525 Planar cell polarity (PCP) is regulated by a core set of conserved genes. Tissir and Goffinet describe the emerging roles of these PCP genes in various developmental processes in the nervous system, including neural tube closure, neuronal migration and axon guidance. Abstract | Full Text | PDF
Molecular mechanisms of dendrite stability Anthony J. Koleske p536 | doi:10.1038/nrn3486 Correct functioning of the brain requires stability as well as plasticity of neural circuits, and loss of stability is associated with numerous neurological disorders. In this Review, Koleske discusses recent insights into the molecular mechanisms that govern long-term dendrite and synapse stabilization. Abstract | Full Text | PDF
Iron metabolism in the CNS: implications for neurodegenerative diseases Tracey A. Rouault p551 | doi:10.1038/nrn3453 Intricate mechanisms regulate iron homeostasis in the CNS. In this Review, Rouault considers the role of brain iron accumulation in several common neurodegenerative disorders and discusses 'neurodegeneration with brain iron accumulation' diseases that are associated with specific genetic mutations. Abstract | Full Text | PDF
Hypnotic suggestion: opportunities for cognitive neuroscience David A. Oakley & Peter W. Halligan p565 | doi:10.1038/nrn3538 Hypnosis is used in treatment contexts and, recently, also as an investigative tool in cognitive neuroscience. Oakley and Halligan review the potential for hypnosis to provide insights into brain mechanisms involved in attention, motor control, pain perception, beliefs and volition and also to produce informative analogues of clinical conditions. Abstract | Full Text | PDF
PERSPECTIVES		Top
SCIENCE AND SOCIETY Article series: Neuroscience and the law Effects of Schedule I drug laws on neuroscience research and treatment innovation David J. Nutt, Leslie A. King & David E. Nichols p577 | doi:10.1038/nrn3530 The possession of psychoactive drugs is subject to national and international regulations. In this Perspective article, Nutt et al. discuss how this situation makes it extremely difficult to obtain licences and investigate both the therapeutic potential and the potential dangers of psychoactive drugs. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Correspondence: Misuse of power: in defence of small-scale science Philip T. Quinlan p585 | doi:10.1038/nrn3475-c1 Full Text | PDF
Correspondence: Experimental power comes from powerful theories — the real problem in null hypothesis testing John C. Ashton p585 | doi:10.1038/nrn3475-c2 Full Text | PDF
Correspondence: Small sample size is not the real problem Peter Bacchetti p585 | doi:10.1038/nrn3475-c3 Full Text | PDF
REPLY		Top
Reply: Confidence and precision increase with high statistical power Katherine S. Button, John P. A. Ioannidis, Claire Mokrysz, Brian A. Nosek, Jonathan Flint, Emma S. J. Robinson & Marcus R. Munafò p585 | doi:10.1038/nrn3475-c4 Full Text | PDF
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Nature Reviews Neuroscience Article Series on Neuroscience and the law This Article Series explores the interaction between neuroscience and the legal system. Read discussions on issues pertaining to criminal responsibility, drug policy, memory and the dissemination of neuroscientific findings in the courtroom. Follow the series here: www.nature.com/nrn/series/neurosciencelaw
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*2012 Journal Citation Report (Thomson Reuters, 2013)

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