Nature Reviews Microbiology contents August 2013 Volume 11 Number 8 pp 505-591

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TABLE OF CONTENTS
August 2013 Volume 11 Number 8
Impact Factor 22.49 *	In this issue Comment Research Highlights News and Analysis Reviews Perspectives Also this month  Featured article: A problem of persistence: still more questions than answers? Nathalie Q. Balaban, Kenn Gerdes, Kim Lewis & John D. McKinney
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Comment: EVIMalaR — a model for international cooperation in scientific research Andrew P. Waters p505 | doi:10.1038/nrmicro3079 Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Microbiome: With a little help from my phage friends p507 | doi:10.1038/nrmicro3070 The phage metagenome of the gut functions as a reservoir of advantageous genes for the microbiota following antibiotic perturbation. PDF Marine microbiology: Drilling deeper p508 | doi:10.1038/nrmicro3071 A metatranscriptomic analysis of the sub-seafloor biosphere reveals metabolic activities from all three domains of life. PDF Host response: True to their family name p508 | doi:10.1038/nrmicro3083 IL-20R signalling inhibits pro-IL-1β expression and underlies susceptibility to infection with Staphylococcus aureus. PDF Bacterial pathogenesis: Limiting DNA repair p510 | doi:10.1038/nrmicro3078 Two pathogenic bacteria impair host DNA repair pathways, potentially leading to carcinogenesis. PDF Symbiosis: A symbiotic mosaic p510 | doi:10.1038/nrmicro3087 Genomic and transcriptomic analyses reveal further genetic complexities in the tripartite nested mealybug symbiosis. PDF Fungal genetics: Candida chooses its code p511 | doi:10.1038/nrmicro3073 Codon ambiguity increases the genetic and phenotypic diversity of Candida albicans, leading to rapid ecological adaptation. PDF IN BRIEF Techniques & Applications: Miniaturizing antifungal drug discovery | Antimicrobials: ROS enables aminoglycoside entry but not lethality | Biofilms: eDNA directs traffic flow | Parasite biology: Immune evasion through silence | Fungal pathogenesis: Two routes to invasion | Microbiome: A bacterial trigger for liver cancer PDF Microbiology JOBS of the week Plant Pathology & Microbiology Lecturer University of California, Riverside Post-Doctoral Bioscience Positions Monash University Post-doctoral Researcher Prof Lise Korsten Postdoctoral Fellow / Postdoctoral Associate US Army Institute of Surgical Research More Science jobs from Microbiology EVENT New Approaches & Concepts in Microbiology 16.10.13 Heidelberg, Germany More science events from
NEWS AND ANALYSIS		Top
GENOME WATCH An elephantine viral problem Astrid Gall & Anne Palser p512 | doi:10.1038/nrmicro3075 This month's Genome Watch highlights how deep sequencing was used to generate the first full genomes of herpesviruses associated with a fatal disease in elephants. PDF
REVIEWS		Top
Cyclic di-AMP: another second messenger enters the fray Rebecca M. Corrigan & Angelika Gründling p513 | doi:10.1038/nrmicro3069 Cyclic di-AMP is one of the latest cyclic nucleotide second messengers to be discovered in bacteria. Here, Corrigan and Gründling provide an overview of the enzymes involved in its synthesis and degradation, the currently known receptor proteins and the cellular pathways that are known to be directly or indirectly controlled by this newly identified second messenger. Abstract | Full Text | PDF | Supplementary information
Breaking and joining single-stranded DNA: the HUH endonuclease superfamily Michael Chandler, Fernando de la Cruz, Fred Dyda, Alison B. Hickman, Gabriel Moncalian & Bao Ton-Hoang p525 | doi:10.1038/nrmicro3067 Many mobile genetic elements, such as transposons, plasmids and viruses, must cleave their own DNA to effect transposition, replication or conjugation. Here, Chandler and colleagues describe the HUH endonucleases, which use a unique mechanism to cleave and rejoin single-stranded DNA in order to mobilize and disseminate such elements. Abstract | Full Text | PDF | Supplementary information
Uncovering the mysteries of hantavirus infections Antti Vaheri, Tomas Strandin, Jussi Hepojoki, Tarja Sironen, Heikki Henttonen, Satu Mäkelä & Jukka Mustonen p539 | doi:10.1038/nrmicro3066 Vaheri and colleagues discuss the molecular and cell biology of hantavirus infection and provide an overview of the virus-induced and immune-mediated pathology caused by this virus family in humans. Abstract | Full Text | PDF
The non-canonical roles of clathrin and actin in pathogen internalization, egress and spread Ashley C. Humphries & Michael Way p551 | doi:10.1038/nrmicro3072 Clathrin-mediated endocytosis is exploited by bacterial and viral pathogens during internalization. Humphries and Way review recent studies which highlight the fact that, in addition to a structural role, clathrin can function as a signalling platform during pathogen entry, and other studies revealing that, in conjunction with actin, clathrin is involved in pathogen cell-cell spread and release. Abstract | Full Text | PDF
Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii Erin J. van Schaik, Chen Chen, Katja Mertens, Mary M. Weber & James E. Samuel p561 | doi:10.1038/nrmicro3049 The obligate intracellular bacterium Coxiella burnetii causes both acute and chronic zoonotic infections. Here, Samuel and colleagues discuss the recent technological advances that have facilitated a deeper understanding of the molecular mechanisms of C. burnetii pathogenesis, including host cell invasion and modulation by virulence factors exported through the type IV Dot/Icm secretion system. Abstract | Full Text | PDF
Modern clinical microbiology: new challenges and solutions Pierre-Edouard Fournier, Michel Drancourt, Philippe Colson, Jean-Marc Rolain, Bernard La Scola & Didier Raoult p574 | doi:10.1038/nrmicro3068 Raoult and colleagues review recent developments in clinical microbiology, including the development of mass spectrometry-based diagnostics and point-of-care tests, which might change clinical practice. Abstract | Full Text | PDF
PERSPECTIVES		Top
VIEWPOINT A problem of persistence: still more questions than answers? Nathalie Q. Balaban, Kenn Gerdes, Kim Lewis & John D. McKinney p587 | doi:10.1038/nrmicro3076 Bacterial persistence poses a major obstacle for current efforts to tackle the global rise of antibiotic resistance. Here, Balaban, Gerdes, Lewis and McKinney discuss the physiological features of persister cells and the factors leading to their emergence, as well as the implications of persistence for antibiotic treatment regimens and bacterial heterogeneity. Abstract | Full Text | PDF
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*2012 Journal Citation Report (Thomson Reuters, 2013)

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