Nature Reviews Genetics Contents August 2013 Volume 14 Number 8 pp 517 - 594

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TABLE OF CONTENTS
August 2013 Volume 14 Number 8		Advertisement
Impact Factor 41.063 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Non-coding RNA Translational genetics Modes of transcriptional regulation  Featured article: Bringing genome-wide association findings into clinical use Teri A. Manolio	Get the most from your NGS data with Sequenom's MassARRAY® system Validate from tens to thousands of samples across tens to hundreds of SNPs Design you own assays against any SNP of interest Run a variety of applications including genotyping, DNA methylation and somatic mutation analysis
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RESEARCH HIGHLIGHTS Top Metagenomics: With a little help from my phage friends p517 | doi:10.1038/nrg3532 PDF Complex traits: Sequencing for disease architecture p518 | doi:10.1038/nrg3533 PDF Epigenetics: X inactivation by titration p518 | doi:10.1038/nrg3538 PDF Gene expression: Disentangling DNA methylation p519 | doi:10.1038/nrg3535 PDF Non-coding RNA: Ribosomes, but no translation, for lincRNAs p520 | doi:10.1038/nrg3534 PDF Stem Cells: Maintaining genomic integrity p520 | doi:10.1038/nrg3536 PDF Genome evolution: Adaptive human regulatory variation p520 | doi:10.1038/nrg3537 PDF IN BRIEF Gene regulation: Regulating transcription directionality | GWAS: Sexually dimorphic traits | Genomics: Sequencing historical plant pathogens | Evolution: A smooth path to C4 photosynthesis | Gene therapy: Improved vector for retinal diseases | Stem cells: Regulating self-renewal | Epigenetics: Transient transcription error inheritance | Development: Expression profiling without cell isolation PDF Genetics JOBS of the week Postdoctoral Position in Bioinformatics Max Planck Institute of Immunobiology and Epigenetics Postdoctoral Research Associate Michigan State University Faculty position in Bioinformatics and Computational Biology University of Iowa Carver College of Medicine Statistical Geneticist / Computational Biologist Stanford University - Dept of cardiovascular medicine Lecturer University of Manchester More Science jobs from Genetics EVENT Short Course on Systems Genetics 08.09.13 Bar Harbor, USA More science events from
REVIEWS		Top
Article series: Non-coding RNA PIWI-interacting RNAs: from generation to transgenerational epigenetics Maartje J. Luteijn & René F. Ketting p523 | doi:10.1038/nrg3495 PIWI-interacting RNAs (piRNAs) have important roles in various species, particularly in silencing transposons in the germ line. This Review describes our latest understanding of various steps in this process, from the specification of piRNA-producing loci to piRNA processing and nuclear effector functions, including a role in transgenerational epigenetic inheritance. Abstract | Full Text | PDF
Article series: Non-coding RNA Adult-specific functions of animal microRNAs Kailiang Sun & Eric C. Lai p535 | doi:10.1038/nrg3471 This Review discusses roles for microRNAs in adult animals — including in adult stem cells, metabolism and in cancer — and how functions in adults can be distinguished from developmental roles using a range of methods. Understanding adult-specific functions has implications for therapeutic manipulation of miRNAs. Abstract | Full Text | PDF
Article series: Translational genetics Bringing genome-wide association findings into clinical use Teri A. Manolio p549 | doi:10.1038/nrg3523 Despite the impact of genome-wide association studies (GWASs) on disease genetics, there has been scepticism about their usefulness in clinical translation. This Review highlights pertinent examples in which clinical application has been achieved or is likely and considers the wider potential for translation. Abstract | Full Text | PDF
Evolutionary biochemistry: revealing the historical and physical causes of protein properties Michael J. Harms & Joseph W. Thornton p559 | doi:10.1038/nrg3540 In this article, the authors present a synthesis of the emerging field of evolutionary biochemistry. This field has profited from the development of experimental techniques that allow the study of the physical mechanisms and evolutionary processes that have constrained and shaped biological molecules. Abstract | Full Text | PDF
Article series: Modes of transcriptional regulation Eukaryotic transcriptional dynamics: from single molecules to cell populations Antoine Coulon, Carson C. Chow, Robert H. Singer & Daniel R. Larson p572 | doi:10.1038/nrg3484 Our understanding of transcription is being improved through single-molecule and genome-wide approaches. Quantitative models are also required to provide insights into the underlying mechanisms of transcription, and the authors discuss how experimental results and models can be brought together. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION From promises to practical strategies in epigenetic epidemiology Jonathan Mill & Bastiaan T. Heijmans p585 | doi:10.1038/nrg3405 The authors discuss strategies and challenges of population-based studies of epigenetic variation. Such studies should contribute to our understanding of the contribution of epigenetic factors to human disease, but need to be performed and interpreted with consideration of their limitations. Abstract | Full Text | PDF
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*2012 Journal Citation Report (Thomson Reuters, 2013)

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