Nature Reviews Cancer content August 2013 Volume 13 Number 8 pp 519-603

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TABLE OF CONTENTS
August 2013 Volume 13 Number 8		Advertisement
Impact Factor 35 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Gene-engineered T cells for cancer therapy Michael H. Kershaw, Jennifer A. Westwood & Phillip K. Darcy	Get the most from your NGS data with Sequenom's MassARRAY® system Validate from tens to thousands of samples across tens to hundreds of SNPs Design you own assays against any SNP of interest Run a variety of applications including genotyping, DNA methylation and somatic mutation analysis
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RESEARCH HIGHLIGHTS Top Cancer stem cells: Easily moulded p519 | doi:10.1038/nrc3573 A paper in Cell reports that breast cancer cells can transition between non-cancer stem cell (CSC)-like and CSC-like states; this is dependent on ZEB1, which can be readily activated by microenvironmental signals in non-CSCs that maintain the chromatin at the ZEB1 promoter in a bivalent state. PDF Tumour suppressors: PTEN surprise p520 | doi:10.1038/nrc3569 A secreted translational variant of PTEN (PTEN-Long) can be taken up by neighbouring cells, where it can inhibit PI3K signalling, and administration of purified PTEN-Long to tumour-bearing mice induces tumour regression. PDF Therapeutics: Embracing instability p521 | doi:10.1038/nrc3570 Two recent papers indicate that increasing the turnover of MYC proteins in tumours might promote the loss of an immature, self-renewing cell population and might, therefore, have a therapeutic impact. PDF IN THE NEWS Hazy, becoming clearer p521 | doi:10.1038/nrc3574 A new study adds weight to the evidence that air pollution is a risk factor for lung cancer. PDF Metabolism: A TIGAR tale p522 | doi:10.1038/nrc3567 Data recently published by Karen Vousden and colleagues indicate that TIGAR aids tumour development in the intestine. PDF Tumour suppression: No contact please p522 | doi:10.1038/nrc3568 Seluanov, Gorbunova and colleagues find that high-molecular-mass hyaluronan — a component of the extracellular matrix — activates early contact inhibition, which suppresses tumorigenesis in naked mole rats. PDF Metastasis: Exit this way p523 | doi:10.1038/nrc3571 Offermanns and colleagues found that tumour cell-activated platelets induce endothelial opening — which promotes extravasation — through adenine nucleotide-mediated activation of P2Y2 on endothelial cells. PDF IN BRIEF Melanoma: Directed therapy | Mathematical models: Two or three is better than one | Cancer models: Getting it right | Glioblastoma: Branching out PDF Cancer JOBS of the week Postdoctoral Fellow in Cancer Biology City of Hope - Beckman Research Institute Postdoctoral position in cancer cell signaling University of Liege Postdoctoral fellow position in the area of Computational Cancer Genomics University of Cologne Senior Hematology / Oncology Faculty University of Maryland Greenebaum Cancer Center (UMGCC) Postdoc in Cancer Immunology, Harvard Medical School Dana-Farber Cancer Institute / Harvard Medical School More Science jobs from Cancer EVENT Molecular Pathology and Diagnosis of Cancer 10.11.13 Cambridge, UK More science events from
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REVIEWS		Top
Gene-engineered T cells for cancer therapy Michael H. Kershaw, Jennifer A. Westwood & Phillip K. Darcy p525 | doi:10.1038/nrc3565 Adoptive T cell therapy using engineered T cells to improve antitumour responses is showing promise for the treatment of haematological malignancies in particular. This Review discusses the strategies to engineer T cells and the progress that has been made with using gene-modified T cells to treat cancer patients. Abstract | Full Text | PDF
DNA helicases involved in DNA repair and their roles in cancer Robert M. Brosh, Jr. p542 | doi:10.1038/nrc3560 Several cancers and genetic disorders are linked to defects in helicases that have roles in genome maintenance and stability. This Review discusses helicase-dependent DNA repair pathways and how targeting these might improve cancer treatments based on DNA-damaging chemotherapy or radiation. Abstract | Full Text | PDF
Role of ABL family kinases in cancer: from leukaemia to solid tumours Emileigh K. Greuber, Pameeka Smith-Pearson, Jun Wang & Ann Marie Pendergast p559 | doi:10.1038/nrc3563 Although the ABL1 kinase is well known as the fusion partner with BCR in chronic myeloid leukaemia (CML), roles for the ABL family (ABL1 and ABL2) in solid tumours are beginning to be uncovered. Small-molecule ABL inhibitors are crucial in CML therapy, but can these kinases be targeted for therapeutic benefit in other cancer types? Abstract | Full Text | PDF
Serine, glycine and one-carbon units: cancer metabolism in full circle Jason W. Locasale p572 | doi:10.1038/nrc3557 This Review reminds us of all those pathways we longed to forget from first year biochemistry: deregulated one-carbon metabolism is a possible driver of oncogenesis. Given the wealth of clinically available agents that target one-carbon metabolism are there opportunities for translation into precision cancer medicine? Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION The DREAM complex: master coordinator of cell cycle-dependent gene expression Subhashini Sadasivam & James A. DeCaprio p585 | doi:10.1038/nrc3556 The DREAM complex provides a previously unsuspected unifying role in the cell cycle. This Opinion article explores the functions of the DREAM complex and how they might contribute to tumour development and progression. Abstract | Full Text | PDF
OPINION The role of engineering approaches in analysing cancer invasion and metastasis Muhammad H. Zaman p596 | doi:10.1038/nrc3564 Can novel materials, probes and tools, which represent an integration of traditional and new engineering approaches with cancer biology, help us to better understand tumour progression and invasion? Abstract | Full Text | PDF
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*2012 Journal Citation Report (Thomson Reuters, 2013)

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