Nature Immunology Contents: August 2013 Volume 14 pp 765 - 877

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ReichertSPR.com Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Check out this open access article from Frontiers in immunology  Vitamin-mediated regulation of intestinal immunity   Jun Kunisawa and Hiroshi Kiyono In this review, the authors focus on the immunologic functions of vitamins in regulating intestinal immune responses and their roles in moderating the fine balance between physiologic and pathologic conditions of the intestine.   Commentary Top Matching cellular dimensions with molecular sizes   pp765 - 767 Michael Reth doi:10.1038/ni.2621 News and Views Top Platelet-macrophage partnership in innate immunity and inflammation   pp768 - 770 Alberto Mantovani and Cecilia Garlanda doi:10.1038/ni.2666 Platelets and phagocytes engage in bidirectional interaction in innate immunity and inflammation. Kupffer cell-platelet cooperation results in the rapid encasement of blood-borne bacteria and host protection. See also: Article by Wong et al. Control of TFH differentiation by a microRNA cluster   pp770 - 771 Yoon-Chi Han and Andrea Ventura doi:10.1038/ni.2671 The generation of T cell-dependent humoral immunity is regulated by the miR-17∼92 cluster of microRNAs through their influence on the differentiation and function of follicular helper T cells. See also: Article by Baumjohann et al. | Article by Kang et al. NLRP3 inflammasome activation: CD36 serves double duty   pp772 - 774 Jonathan C Kagan and Tiffany Horng doi:10.1038/ni.2668 Studies have linked the NLRP3 inflammasome pathway to the elaboration of sterile inflammation. CD36 serves a dual role by priming transcription of the gene encoding interleukin 1β (IL-1β) and inducing assembly of the NLRP3 inflammasome complex, which leads to the release of active IL-1β. See also: Article by Sheedy et al. The IL-20 cytokine subfamily: bad guys in host defense?   pp774 - 775 Daniel H Kaplan doi:10.1038/ni.2664 Resistance to infection of the skin with Staphylococcus aureus depends on early production of interleukin 1β (IL-1β) and IL-17A by skin-resident cells. However, several members of the IL-20 subfamily of cytokines (IL-19, IL-20 and IL-24) can inhibit the local generation of those two cytokines. See also: Article by Myles et al. Immunology JOBS of the week Tenure-Track Faculty Positions in Microbiology & Immunology University at Buffalo, School of Medicine and Biomedical Sciences Postdoctoral scientist in Immunology Deutsches Rheuma-Forschungszentrum Berlin (DRFZ) Immunology postdoc University of Arizona M.Sc. (Masters) in Immunology School of Biochemistry and Immunology, Trinity College Dublin More Science jobs from Immunology EVENT EMBO Workshop on Complex Systems in Immunology 2nd Dec 2013 Singapore More science events from Research Highlights Top Boosting cancer immunotherapy | Integration-induced death | Metabolic control of cytokines | Barrier with a bite | NO to Leishmania | Evolving away Perspective Top Short-term memory of danger signals and environmental stimuli in immune cells   pp777 - 784 Silvia Monticelli and Gioacchino Natoli doi:10.1038/ni.2636 Articles Top Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance   pp785 - 792 Connie H Y Wong, Craig N Jenne, Bjorn Petri, Navina L Chrobok and Paul Kubes doi:10.1038/ni.2631 Platelet activation contributes to blood coagulation. Kubes and colleagues show that platelets also act together with liver Kupffer cells to trap and eradicate blood-borne bacteria. See also: News and Views by Mantovani & Garlanda Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity   pp793 - 803 Jianhua Li, Kuancheng Liu, Yang Liu, Yan Xu, Fei Zhang et al. doi:10.1038/ni.2647 Exosomes have diverse physiological roles. Yuan and colleagues show that packaging of antiviral molecules into exosomes, followed by their release, is important in resistance to hepatitis viruses. Signaling via the IL-20 receptor inhibits cutaneous production of IL-1β and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus    pp804 - 811 Ian A Myles, Natalia M Fontecilla, Patricia A Valdez, Paul J Vithayathil, Shruti Naik et al. doi:10.1038/ni.2637 Cytokines that signal via IL-20R have been linked to autoinflammatory skin disease, but their role in infection is poorly understood. Datta and colleagues show that IL-20R signaling suppresses the production of IL-1β and IL-17 and dampens skin antibacterial responses. See also: News and Views by Kaplan CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation   pp812 - 820 Frederick J Sheedy, Alena Grebe, Katey J Rayner, Parisa Kalantari, Bhama Ramkhelawon et al. doi:10.1038/ni.2639 Particulate crystals can activate the NLRP3 inflammasome. Moore and colleagues show that the scavenger protein CD36 contributes to sterile inflammation via uptake of soluble cholesterol and amyloid peptides that nucleate into intracellular crystals. See also: News and Views by Kagan & Horng Origin of monocytes and macrophages in a committed progenitor   pp821 - 830 Jan Hettinger, David M Richards, Jenny Hansson, Melanie M Barra, Ann-Cathrin Joschko et al. doi:10.1038/ni.2638 The distal pathways for differentiation into monocytes and monocyte-derived macrophages are not fully elucidated. Feuerer and colleagues describe a clonogenic, monocyte- and macrophage-restricted progenitor derived from the macrophage-dendritic cell progenitor. The nuclear receptor LXRα controls the functional specialization of splenic macrophages   pp831 - 839 Noelia A-Gonzalez, Jose A Guillen, Germán Gallardo, Mercedes Diaz, Juan V de la Rosa et al. doi:10.1038/ni.2622 Liver X receptors (LXRs) are transcription factors that respond to sterols. Castrillo and colleagues identify a unique requirement for LXRα in the development of splenic marginal zone macrophages and their antibody responses to blood-borne antigen. The microRNA cluster miR-17∼92 promotes TFH cell differentiation and represses subset-inappropriate gene expression   pp840 - 848 Dirk Baumjohann, Robin Kageyama, Jonathan M Clingan, Malika M Morar, Sana Patel et al. doi:10.1038/ni.2642 The robust generation of high-affinity antibodies by germinal center B cells requires help provided by TFH cells. Ansel and Xiao and their colleagues show that the microRNA family miR-17~92 regulates the differentiation and function of TFH cells. See also: News and Views by Han & Ventura MicroRNAs of the miR-17∼92 family are critical regulators of TFH differentiation   pp849 - 857 Seung Goo Kang, Wen-Hsien Liu, Peiwen Lu, Hyun Yong Jin, Hyung W Lim et al. doi:10.1038/ni.2648 The robust generation of high-affinity antibodies by germinal center B cells requires help provided by TFH cells. Ansel and Xiao and their colleagues show that the microRNA family miR-17~92 regulates the differentiation and function of TFH cells. See also: News and Views by Han & Ventura The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells   pp858 - 866 Yinming Liang, Margot Cucchetti, Romain Roncagalli, Tadashi Yokosuka, Aurélie Malzac et al. doi:10.1038/ni.2634 T cells require CD28 costimulation for physiological activation. Malissen and colleagues show that the actin-uncapping protein Rltpr is needed to convey CD28 signaling by recruiting PKC&thetas; and Carma1 to the immunological synapse. Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells   pp867 - 875 Robert Nechanitzky, Duygu Akbas, Stefanie Scherer, Ildiko Györy, Thomas Hoyler et al. doi:10.1038/ni.2641 Lineage-commitment factors enforce irreversible loss of alternative lineage potentials during development. Grosschedl and colleagues show that EBF1 expression in committed pro-B cells suppresses T cell and innate lymphoid cell potential. Errata Top ASCertaining cytoskeletal rearrangements in antigen presentation and migration   p876 Ioannis Karakasiliotis and Dimitris L Kontoyiannis doi:10.1038/ni0813-876a TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy   p876 Jeffrey P Marcoe, James R Lim, Keri L Schaubert, Nassima Fodil-Cornu, Marsel Matka et al. doi:10.1038/ni0813-876b Sensing and alarm function of resident memory CD8+ T cells   p876 Jason M Schenkel, Kathryn A Fraser, Vaiva Vezys and David Masopust doi:10.1038/ni0813-876c Can DCs be distinguished from macrophages by molecular signatures?   p876 David A Hume, Neil Mabbott, Sobia Raza and Tom C Freeman doi:10.1038/ni0813-876d The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells   p876 Dominique Gatto, Katherine Wood, Irina Caminschi, Danielle Murphy-Durland, Peter Schofield et al. doi:10.1038/ni0813-876e Corrigenda Top SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates   p877 Hichem Lahouassa, Waaqo Daddacha, Henning Hofmann, Diana Ayinde, Eric C Logue et al. doi:10.1038/ni0813-877a The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway   p877 Lucille Rankin, Joanna R Groom, Michaél Chopin, Marco J Herold, Jennifer A Walker et al. doi:10.1038/ni0813-877b Mcl-1 is essential for the survival of plasma cells   p877 Victor Peperzak, Ingela Vikstrom, Jennifer Walker, Stefan P Glaser, Melanie LePage et al. doi:10.1038/ni0813-877c The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock   p877 Ezra Aksoy, Salma Taboubi, David Torres, Sandrine Delbauve, Abderrahman Hachani et al. doi:10.1038/ni0813-877d OASL1 inhibits translation of the type I interferon-regulating transcription factor IRF7   p877 Myeong Sup Lee, Byungil Kim, Goo Taeg Oh and Young-Joon Kim doi:10.1038/ni0813-877e Top Advertisement nature.com webcasts Macmillan Science Communication presents a custom webcast on:  Accelerating the discovery and development of monoclonal antibodies Wednesday July 31st 2013 7am PDT / 10am EDT / 3pm BST / 4pm CEST Register for the free webcast followed by our live Q & A session  Sponsored by: Perkin Elmer      Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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