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|  |  |  | Volume 27, Issue 7 (July 2013) |  | In this issue
Spotlight Review
Review
Original Articles
Letters To The Editor
Corrigendum
Also new
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|  |  | Spotlight Review | Top |  | SPOTLIGHT ON CLONAL EVOLUTION IN LEUKEMIAS
| An evolutionary perspective on chronic myelomonocytic leukemiaR Itzykson and E Solary Leukemia 2013 27: 1441-1450; advance online publication, April 5, 2013; 10.1038/leu.2013.100 Abstract | Full Text |  | Review | Top |  | Novel therapies for children with acute myeloid leukaemiaA S Moore, P R Kearns, S Knapper, A D J Pearson and C M Zwaan Leukemia 2013 27: 1451-1460; advance online publication, April 8, 2013; 10.1038/leu.2013.106 Abstract | Full Text |  | Original Articles | Top |  | ACUTE LEUKEMIAS
| The AAA+ ATPase RUVBL2 is a critical mediator of MLL-AF9 oncogenesisH Osaki, V Walf-Vorderwülbecke, M Mangolini, L Zhao, S J Horton, G Morrone, J J Schuringa, J de Boer and O Williams Leukemia 2013 27: 1461-1468; advance online publication, February 13, 2013; 10.1038/leu.2013.42 Abstract | Full Text |  |  |  | The viral oncogene Np9 acts as a critical molecular switch for co-activating β-catenin, ERK, Akt and Notch1 and promoting the growth of human leukemia stem/progenitor cellsT Chen, Z Meng, Y Gan, X Wang, F Xu, Y Gu, X Xu, J Tang, H Zhou, X Zhang, X Gan, C Van Ness, G Xu, L Huang, X Zhang, Y Fang, J Wu, S Zheng, J Jin, W Huang and R Xu Leukemia 2013 27: 1469-1478; advance online publication, January 11, 2013; 10.1038/leu.2013.8 Abstract | Full Text |  |  |  | A phase Ib GOELAMS study of the mTOR inhibitor RAD001 in association with chemotherapy for AML patients in first relapseS Park, N Chapuis, F Saint Marcoux, C Recher, T Prebet, P Chevallier, J-Y Cahn, T Leguay, P Bories, F Witz, T Lamy, P Mayeux, C Lacombe, C Demur, J Tamburini, A Merlat, R Delepine, N Vey, F Dreyfus, M C Béné, N Ifrah and D Bouscary GOELAMS (Groupe Ouest Est d’Etude des Leucémies aiguës et Autres Maladies du Sang) Leukemia 2013 27: 1479-1486; advance online publication, January 16, 2013; 10.1038/leu.2013.17 Abstract | Full Text |  |  |  | C/EBPα and MYB regulate FLT3 expression in AMLG Volpe, D S Walton, W Del Pozzo, P Garcia, E Dassé, L P O'Neill, M Griffiths, J Frampton and S Dumon Leukemia 2013 27: 1487-1496; advance online publication, January 23, 2013; 10.1038/leu.2013.23 Abstract | Full Text |  |  |  | High-risk childhood acute lymphoblastic leukemia in first remission treated with novel intensive chemotherapy and allogeneic transplantationG M Marshall, L Dalla Pozza, R Sutton, A Ng, H A de Groot-Kruseman, V H van der Velden, N C Venn, H van den Berg, E S J M de Bont, R Maarten Egeler, P M Hoogerbrugge, G J L Kaspers, M B Bierings, E van der Schoot, J van Dongen, T Law, S Cross, H Mueller, V de Haas, M Haber, T Révész, F Alvaro, R Suppiah, M D Norris and R Pieters Leukemia 2013 27: 1497-1503; advance online publication, February 14, 2013; 10.1038/leu.2013.44 Abstract | Full Text |  |  |  | MYELODYSPLASIAS
| Mayo prognostic model for WHO-defined chronic myelomonocytic leukemia: ASXL1 and spliceosome component mutations and outcomesM M Patnaik, E Padron, R R LaBorde, T L Lasho, C M Finke, C A Hanson, J M Hodnefield, R A Knudson, R P Ketterling, A Al-kali, A Pardanani, N A Ali, R S Komroji and A Tefferi Leukemia 2013 27: 1504-1510; advance online publication, March 27, 2013; 10.1038/leu.2013.88 Abstract | Full Text |  |  |  | CHRONIC MYELOPROLIFERATIVE NEOPLASIAS
| Chronic fatigue is the most important factor limiting health-related quality of life of chronic myeloid leukemia patients treated with imatinibF Efficace, M Baccarani, M Breccia, F Cottone, G Alimena, G L Deliliers, C Baratè, G Specchia, R Di Lorenzo, L Luciano, D Turri, B Martino, F Stagno, M Dabusti, M Bergamaschi, P Leoni, M P Simula, L Levato, C Fava, D Veneri, S Sica, A Rambaldi, G Rosti, M Vignetti and F Mandelli Leukemia 2013 27: 1511-1519; advance online publication, February 18, 2013; 10.1038/leu.2013.51 Abstract | Full Text |  |  |  | Impact of malignant stem cell burden on therapy outcome in newly diagnosed chronic myeloid leukemia patientsS Mustjoki, J Richter, G Barbany, H Ehrencrona, T Fioretos, T Gedde-Dahl, B T Gjertsen, R Hovland, S Hernesniemi, D Josefsen, P Koskenvesa, I Dybedal, B Markevärn, T Olofsson, U Olsson-Strömberg, K Rapakko, S Thunberg, L Stenke, B Simonsson, K Porkka and H Hjorth-Hansen for the Nordic CML Study Group (NCMLSG) Leukemia 2013 27: 1520-1526; advance online publication, January 18, 2013; 10.1038/leu.2013.19 Abstract | Full Text |  |  |  | IMMUNOLOGY
| IL-22 deficiency in donor T cells attenuates murine acute graft-versus-host disease mortality while sparing the graft-versus-leukemia effectM Couturier, B Lamarthée, J Arbez, J-C Renauld, C Bossard, F Malard, F Bonnefoy, M Mohty, S Perruche, P Tiberghien, P Saas and B Gaugler Leukemia 2013 27: 1527-1537; advance online publication, February 12, 2013; 10.1038/leu.2013.39 Abstract | Full Text |  |  |  | Generation of multi-leukemia antigen-specific T cells to enhance the graft-versus-leukemia effect after allogeneic stem cell transplantG Weber, U Gerdemann, I Caruana, B Savoldo, N F Hensel, K R Rabin, E J Shpall, J J Melenhorst, A M Leen, A J Barrett and C M Bollard Leukemia 2013 27: 1538-1547; advance online publication, March 1, 2013; 10.1038/leu.2013.66 Abstract | Full Text |  |  |  | ONCOGENES, FUSION GENES AND TUMOR SUPPRESSOR GENES
| Notch signaling in acute promyelocytic leukemiaN R Grieselhuber, J M Klco, A M Verdoni, T Lamprecht, S M Sarkaria, L D Wartman and T J Ley Leukemia 2013 27: 1548-1557; advance online publication, March 4, 2013; 10.1038/leu.2013.68 Abstract | Full Text |  |  |  | MYELOMA
| Anti-Notch treatment prevents multiple myeloma cells localization to the bone marrow via the chemokine system CXCR4/SDF-1L Mirandola, L Apicella, M Colombo, Y Yu, D G Berta, N Platonova, E Lazzari, M Lancellotti, G Bulfamante, E Cobos, M Chiriva-Internati and R Chiaramonte Leukemia 2013 27: 1558-1566; advance online publication, January 28, 2013; 10.1038/leu.2013.27 Abstract | Full Text |  | Letters To The Editor | Top |  | Nilotinib shows prolonged intracellular accumulation upon pulse-exposure: a novel mechanism for induction of apoptosis in CML cellsM-C Wagner, M Dziadosz, J V Melo, F Heidel, T Fischer and D B Lipka Leukemia 2013 27: 1567-1570; advance online publication, December 12, 2012; 10.1038/leu.2012.364 Full Text |  |  |  | Initially disadvantaged, TEL-AML1 cells expand and initiate leukemia in response to irradiation and cooperating mutations OpenM Li, L Jones, C Gaillard, M Binnewies, R Ochoa, E Garcia, V Lam, G Wei, W Yang, C Lobe, M Hermiston, E Passegué and S C Kogan Leukemia 2013 27: 1570-1573; advance online publication, January 16, 2013; 10.1038/leu.2013.15 Full Text |  |  |  | Landmark analysis of DNMT3A mutations in hematological malignanciesA Roller, V Grossmann, U Bacher, F Poetzinger, S Weissmann, N Nadarajah, L Boeck, W Kern, C Haferlach, S Schnittger, T Haferlach and A Kohlmann Leukemia 2013 27: 1573-1578; advance online publication, March 1, 2013; 10.1038/leu.2013.65 Full Text |  |  |  | BCR-ABL mediated repression of miR-223 results in the activation of MEF2C and PTBP2 in chronic myeloid leukemiaS Agatheeswaran, S Singh, S Biswas, G Biswas, N Chandra Pattnayak and S Chakraborty Leukemia 2013 27: 1578-1580; advance online publication, November 23, 2012; 10.1038/leu.2012.339 Full Text |  |  |  | Decitabine facilitates the generation and immunosuppressive function of regulatory γδT cells derived from human peripheral blood mononuclear cellsY Hu, Q Cui, Y Gu, L Sheng, K Wu, J Shi, Y Tan, H Fu, L Liu, S Fu, X Yu and H Huang Leukemia 2013 27: 1580-1585; advance online publication, November 29, 2012; 10.1038/leu.2012.345 Full Text |  |  |  | Deficiency of CREB and over expression of miR-183 in juvenile myelomonocytic leukemia OpenY L Liu, S Y Lensing, Y Yan, T M Cooper, M L Loh and P D Emanuel Leukemia 2013 27: 1585-1588; advance online publication, February 18, 2013; 10.1038/leu.2013.49 Full Text |  |  |  | GADD45A methylation predicts poor overall survival in acute myeloid leukemia and is associated with IDH1/2 and DNMT3A mutationsM Perugini, D G Iarossi, C H Kok, N Cummings, S M Diakiw, A L Brown, S Danner, P Bardy, L Bik To, A H Wei, I D Lewis and R J D'Andrea Leukemia 2013 27: 1588-1592; advance online publication, November 28, 2012; 10.1038/leu.2012.346 Full Text |  |  |  | Murine mantle cell lymphoma model cell lineM R Smith, I Joshi, J Pei, M Slifker, F Jin, J R Testa and T Al-Saleem Leukemia 2013 27: 1592-1594; advance online publication, December 28, 2012; 10.1038/leu.2012.370 Full Text |  |  |  | The Fc-engineered CD19 antibody MOR208 (XmAb5574) induces natural killer cell-mediated lysis of acute lymphoblastic leukemia cells from pediatric and adult patientsC Kellner, E A Zhukovsky, A Pötzke, M Brüggemann, A Schrauder, M Schrappe, M Kneba, R Repp, A Humpe, M Gramatzki and M Peipp Leukemia 2013 27: 1595-1598; advance online publication, January 1, 2013; 10.1038/leu.2012.373 Full Text |  |  |  | STAT3 mutations are highly specific for large granular lymphocytic leukemiaA Fasan, W Kern, V Grossmann, C Haferlach, T Haferlach and S Schnittger Leukemia 2013 27: 1598-1600; advance online publication, December 4, 2012; 10.1038/leu.2012.350 Full Text |  |  |  | Frequent somatic mutations in components of the RNA processing machinery in chronic lymphocytic leukemiaA J Ramsay, D Rodríguez, N Villamor, A Kwarciak, J R Tejedor, J Valcárcel, A López-Guillermo, A Martínez-Trillos, X S Puente, E Campo, C López-Otín and V Quesada Leukemia 2013 27: 1600-1603; advance online publication, November 28, 2012; 10.1038/leu.2012.344 Full Text |  |  |  | Novel TAL1 targets beyond protein-coding genes: identification of TAL1-regulated microRNAs in T-cell acute lymphoblastic leukemiaN C Correia, K Durinck, A P Leite, M Ongenaert, P Rondou, F Speleman, F J Enguita and J T Barata Leukemia 2013 27: 1603-1606; advance online publication, March 1, 2013; 10.1038/leu.2013.63 Full Text |  |  |  | All-trans retinoic acid and arsenic trioxide resistance of acute promyelocytic leukemia with the variant STAT5B-RARA fusion geneS Strehl, M König, H Boztug, B W Cooper, K Suzukawa, S-J Zhang, H-Y Chen, A Attarbaschi and M N Dworzak Leukemia 2013 27: 1606-1610; advance online publication, December 28, 2012; 10.1038/leu.2012.371 Full Text |  |  |  | A G polymorphism in the CRBN gene acts as a biomarker of response to treatment with lenalidomide in low/int-1 risk MDS without del(5q)V Sardnal, A Rouquette, S Kaltenbach, C Bally, V Chesnais, C Leschi, L Ades, V Santini, S Park, A Toma, P Fenaux, F Dreyfus, M Fontenay and O Kosmider Leukemia 2013 27: 1610-1613; advance online publication, February 26, 2013; 10.1038/leu.2013.59 Full Text |  |  |  | Loss of Tcf7 diminishes hematopoietic stem/progenitor cell functionG Huls, J van Es, H Clevers, G de Haan and R van Os Leukemia 2013 27: 1613-1614; advance online publication, December 5, 2012; 10.1038/leu.2012.354 Full Text |  | Corrigendum | Top |  | Polymorphisms in xenobiotic transporters ABCB1, ABCG2, ABCC2, ABCC1, ABCC3 and multiple myeloma risk: a case—control study in the context of the International Multiple Myeloma rESEarch (IMMEnSE) consortiumA Martino, D Campa, G Buda, J Sainz, R García-Sanz, K Jamroziak, R M Reis, N Weinhold, M Jurado, R Ríos, Z Szemraj-Rogucka, H Marques, J Szemraj, A Stein, R Kumar, E Orciuolo, F Gemignani, S Landi, H Goldschmidt, M Petrini, C Dumontet, F Canzian and A M Rossi Leukemia 2013 27: 1615-1616; 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