Drug Discovery@nature.com 19 July 2013

TABLE OF CONTENTS 19 July 2013 News Analysis Research Highlights Research & Reviews Careers Nature Reviews Drug Discovery is on Twitter Advertisement WE launched in 2011 YOU published 2000 papers with us OUR impact factor is 2.927* Discover what we can do together. nature.com/scientificreports *2012 Journal Citation Reports® (Thomson Reuters, 2013)   News Top NIH gambles on recycled drugs doi:10.1038/499263a Early success could bolster congressional support for agency’s translational science centre. Full Text Investors start backing hearing loss treatments doi:10.1038/nbt0713-575 Several investors are now betting that developing new drugs for hearing loss indications has a similar potential to ophthalmology. Full Text Nerve growth stimulates prostate cancer doi:10.1038/nature.2013.13373 Dense arrangement of nerves linked to aggressive disease. Full Text Crowdsourced contest identifies best-in-class breast cancer prognostic doi:10.1038/nbt0713-578b Two Science Translational Medicine papers demonstrate the power of open innovation for tackling concrete clinical problems. Full Text Analysis Top Debugging Crohn's disease doi:10.1038/scibx.2013.644 Researchers have used mannosides to directly target adherent-invasive Escherichia coli, which cause intestinal inflammation in Crohn's disease. The team is planning to test this alternative to standard-of-care TNF-lowering therapies in a mouse model for chronic Crohn’s disease. Full Text New hope for dry AMD? doi:10.1038/nrd4038 There are no specific drugs on the market for dry age-related macular degeneration (AMD), but a pipeline of promising therapies are in development. Full Text Research Highlights Top Tumour immunology: Cracking the combination doi:10.1038/nri3481 Combined immunotherapies target macrophages and regulatory T cells to enhance antitumour responses. Full Text Metabolic disorders: Betatrophin boosts β-cells doi:10.1038/nrd4058 A novel liver-secreted hormone named betatrophin promotes β-cell proliferation and improves glucose tolerance in mice. Full Text Cancer: IL-22: linking inflammation and cancer doi:10.1038/nrd4065 IL-22 is a key player in the transition from intestinal inflammation to cancer. Full Text Research & Reviews Top Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease doi:10.1038/nrd4024 The therapeutic application of neurotrophins is limited by their poor pharmacological properties and undesirable pleiotropic actions. Targeting individual neurotrophin receptors using small-molecule ligands may overcome these limitations. Full Text New anti-inflammatory targets for chronic obstructive pulmonary disease doi:10.1038/nrd4025 This article highlights new therapeutic targets for COPD that have been discovered through a better understanding of the underlying inflammation, and discusses the development of anti-inflammatory drugs for this disorder. Full Text Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host doi:10.1038/nrc3486 The authors propose a model that suggests a new approach to cancer diagnosis and therapy that focuses on epigenetic dysregulation, and discuss its potential for risk detection and chemoprevention. Full Text In vivo cardiac reprogramming contributes to zebrafish heart regeneration doi:10.1038/nature12322 A cardiac injury study in zebrafish reveals the plasticity of heart cell lineages as shown by a Notch-dependent transdifferentiation of atrial to ventricular cardiomyocytes, regenerating a cell type that is damaged in human heart failure. Full Text Drug Discovery JOBS of the week PhD in Biomedical Engineering: Ultrasound for Drug Delivery University of Glasgow Postdoctoral Research Associate - Drug Metabolism University of Washington Postdoctoral Position in Molecular Biology and Drug Discovery Moffitt Cancer Center & Research Institute PhD student and Postdoctoral Research Scientist Positions in Drug Discovery Shanghai Jiaotong University Senior Scientist, Drug Discovery e-Therapeutics PLC More Science jobs from Drug Discovery EVENT 14th International Conference on Alzheimer's Drug Discovery 09.09.13 Jersey City, USA More science events from Careers Top Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. Full Text Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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