Drug Discovery@nature.com 12 July 2013

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Full Text First microRNA mimic enters clinic doi:10.1038/nbt0713-577 Mirna Therapeutics’ MRX34 enters Phase I trials for primary liver cancer or metastatic cancer with liver involvement. Full Text Patent watch: United States to tackle patent trolls doi:10.1038/nrd4070 The United States wants to bring in changes to its patent laws that will make it harder for so-called patent trolls to operate. Full Text An Audience With: David Haslam doi:10.1038/nrd4053 The new Chairman of NICE discusses value-based pricing, cost–benefit appraisals of drugs for rare diseases and the organization's expanded remit. Full Text Analysis Top New hope for dry AMD? doi:10.1038/nrd4038 There are no specific drugs on the market for dry age-related macular degeneration (AMD), but a pipeline of promising therapies are in development. Full Text NCATS's nine lives doi:10.1038/scibx.2013.616 The NIH's National Center for Advancing Translational Sciences has awarded a total of $12.7 million to 9 academic research groups to repurpose compounds from 5 pharma partners in the center's Discovering New Therapeutic Uses for Existing Molecules program. Full Text Research Highlights Top Tumour immunology: Cracking the combination doi:10.1038/nri3481 Combined immunotherapies target macrophages and regulatory T cells to enhance antitumour responses. Full Text Metabolic disorders: Betatrophin boosts β-cells doi:10.1038/nrd4058 A novel liver-secreted hormone named betatrophin promotes β-cell proliferation and improves glucose tolerance in mice. Full Text Cancer: IL-22: linking inflammation and cancer doi:10.1038/nrd4065 IL-22 is a key player in the transition from intestinal inflammation to cancer. Full Text Research & Reviews Top Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease doi:10.1038/nrd4024 The therapeutic application of neurotrophins is limited by their poor pharmacological properties and undesirable pleiotropic actions. Targeting individual neurotrophin receptors using small-molecule ligands may overcome these limitations. Full Text New anti-inflammatory targets for chronic obstructive pulmonary disease doi:10.1038/nrd4025 This article highlights new therapeutic targets for COPD that have been discovered through a better understanding of the underlying inflammation, and discusses the development of anti-inflammatory drugs for this disorder. Full Text Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host doi:10.1038/nrc3486 The authors propose a model that suggests a new approach to cancer diagnosis and therapy that focuses on epigenetic dysregulation, and discuss its potential for risk detection and chemoprevention. Full Text In vivo cardiac reprogramming contributes to zebrafish heart regeneration doi:10.1038/nature12322 A cardiac injury study in zebrafish reveals the plasticity of heart cell lineages as shown by a Notch-dependent transdifferentiation of atrial to ventricular cardiomyocytes, regenerating a cell type that is damaged in human heart failure. Full Text Drug Discovery JOBS of the week Senior Scientist, Drug Discovery e-Therapeutics PLC Research Fellow (Drug Delivery) Queen’s University Belfast Postdoc in Computational Drug Design University of Copenhagen - Faculty of Medical and Health Sciences Postdoctoral Fellow – Drug Discovery / GU Oncology Moffitt Cancer Center & Research Institute Research Assistant: Vaccinology - Malaria Vaccine Design University of Oxford (Medical Sciences Division) More Science jobs from Drug Discovery EVENT Venomics: Drug Discovery from Nature’s Deadliest 04.11.13 New York, USA More science events from Careers Top Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. Full Text Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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