TABLE OF CONTENTS
| 12 June 2013 | Volume 32, Issue 12 |  |  |  |  | Editorial Have you seen? Review Articles Also new AOP | |  |  | | Advertisement |  | EMBO Transparent Process TRANSPARENT - Referee reports published (without attribution) - No confidential comments FAIR - Referee cross-commenting for balanced decisions - Scooping protection during review and revision FAST - <1 week to a first decision and <1 month to complete peer-review - >90% of published manuscripts undergo a single round of revision (taking on average 3 months) - >95% invited revisions are published | | | |  |  | Editorial | Top |  |  |  | Impact fact-or fiction? The Declaration on Research Assessment (DORA) challenges the use of non-objective measures of research quality, in particular the Journal Impact Factor. Bernd Pulverer The EMBO Journal (2013), 32, 1651 - 1652; 10.1038/emboj.2013.126 Abstract | Full text | PDF Published online: 17 May 2013 |  | Have you seen? | Top |  |  |  | Antisense now makes sense: dual modulation of androgen-dependent transcription by CTBP1-AS The novel ncRNA CTBP1-AS functions in both cis- and trans-regulatory fashion to affect gene expression during prostate cancer progression. Ying Ying Sung and Edwin Cheung The EMBO Journal (2013), 32, 1653 - 1654; 10.1038/emboj.2013.112 Abstract | Full text | PDF Published online: 10 May 2013 |  |  |  | It's getting HOT at telomeres A shelterin-independent direct telomere repeat binding protein helps to match up chromosome ends with active telomerase. Madalena Tarsounas The EMBO Journal (2013), 32, 1655 - 1657; 10.1038/emboj.2013.119 Abstract | Full text | PDF | Related article Published online: 17 May 2013 |  |  |  | Cytonemes extend their reach Cytonemes are specialized filopodia thought to transfer signalling factors between invertebrate cells. A recent study reveals that the ligand Sonic Hedgehog (SHH) also moves on long cytonemes to target distant cells in the chick embryo limb bud. Thomas B Kornberg The EMBO Journal (2013), 32, 1658 - 1659; 10.1038/emboj.2013.115 Abstract | Full text | PDF | Related article Published online: 14 May 2013 |  | Review | Top |  |  |  | Unconventional protein secretion: an evolving mechanism Malhotra reviews recent advances made in the field of unconventional protein secretion and proposes a new model for how proteins are secreted, independent of the classical ER–Golgi pathway. Vivek Malhotra The EMBO Journal (2013), 32, 1660 - 1664; 10.1038/emboj.2013.104 Abstract | Full text | PDF Published online: 10 May 2013 |  | Articles | Top |  |  |  | Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer CTBP1-AS, a ncRNA induced in prostate cancer, regulates androgen receptor (AR) signalling by repressing transcription of the AR-corepressor CTBP1 and cell cycle inhibitors through recruitment of the RNA binding transcriptional repressor PSF and histone deacetylases. Ken-ichi Takayama, Kuniko Horie-Inoue, Shintaro Katayama, Takashi Suzuki, Shuichi Tsutsumi, Kazuhiro Ikeda, Tomohiko Urano, Tetsuya Fujimura, Kiyoshi Takagi, Satoru Takahashi, Yukio Homma, Yasuyoshi Ouchi, Hiroyuki Aburatani, Yoshihide Hayashizaki and Satoshi Inoue The EMBO Journal (2013), 32, 1665 - 1680; 10.1038/emboj.2013.99 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 03 May 2013 |  |  |  | HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment EMBO Open A homeobox protein binds double-stranded telomeric DNA sequences independent of the shelterin complex, and interacts with active telomerase to positively regulate telomere length. Dennis Kappei, Falk Butter, Christian Benda, Marion Scheibe, Irena Draškovič, Michelle Stevense, Clara Lopes Novo, Claire Basquin, Masatake Araki, Kimi Araki, Dragomir Blazhev Krastev, Ralf Kittler, Rolf Jessberger, J Arturo Londoño-Vallejo, Matthias Mann and Frank Buchholz The EMBO Journal (2013), 32, 1681 - 1701; 10.1038/emboj.2013.105 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 17 May 2013 |  |  |  | Toxoplasma gondii myosin F, an essential motor for centrosomes positioning and apicoplast inheritance Inheritance of the Apicomplexa-specific organelle apicoplast in Toxoplasma gondii is an actin-dependent process that is mediated by the myosin F motor, also involved in centrosome positioning during Toxoplasma division. Damien Jacot, Wassim Daher and Dominique Soldati-Favre The EMBO Journal (2013), 32, 1702 - 1716; 10.1038/emboj.2013.113 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 21 May 2013 |  |  |  | Recruitment of arfaptins to the trans-Golgi network by PI(4)P and their involvement in cargo export Arfaptins, BAR domain-containing proteins, bind PI(4)P at the Golgi in a protein kinase D-dependent manner to regulate the biogenesis of secretory storage granules. David Cruz-Garcia, Maria Ortega-Bellido, Margherita Scarpa, Julien Villeneuve, Marko Jovic, Marc Porzner, Tamas Balla, Thomas Seufferlein and Vivek Malhotra The EMBO Journal (2013), 32, 1717 - 1729; 10.1038/emboj.2013.116 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 21 May 2013 |  |  |  | Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity Reduced Eps8 levels in brains of autism patients correlate with impaired spine morphogenesis and cognitive function in Eps8-deficient mice, suggesting causal links between actin-remodelling defects and certain intellectual disabilities. Elisabetta Menna, Stefania Zambetti, Raffaella Morini, Andrea Donzelli, Andrea Disanza, Daniela Calvigioni, Daniela Braida, Chiara Nicolini, Marta Orlando, Giuliana Fossati, Maria Cristina Regondi, Linda Pattini, Carolina Frassoni, Maura Francolini, Giorgio Scita, Mariaelvina Sala, Margaret Fahnestock and Michela Matteoli The EMBO Journal (2013), 32, 1730 - 1744; 10.1038/emboj.2013.107 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 17 May 2013 |  |  |  | Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development The E3 ligase FSN-1 regulates insulin signalling and synapse development in C. elegans by targeting EGL-3, a prohormone convertase that processes insulin ligands. Wesley L Hung, Christine Hwang, ShangBang Gao, Edward H Liao, Jyothsna Chitturi, Ying Wang, Hang Li, Christian Stigloher, Jean-Louis Bessereau and Mei Zhen The EMBO Journal (2013), 32, 1745 - 1760; 10.1038/emboj.2013.91 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 10 May 2013 |  |  |  | Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylation Dissection of the interplay between mitotic checkpoint kinases in flies reveals a key role for Polo kinase in Mps1 kinetochore recruitment, demonstrating the adaptive plasticity of metazoan spindle assembly checkpoint signalling. Carlos Conde, Mariana Osswald, João Barbosa, Tatiana Moutinho-Santos, Diana Pinheiro, Sofia Guimarães, Irina Matos, Helder Maiato and Claudio E Sunkel The EMBO Journal (2013), 32, 1761 - 1777; 10.1038/emboj.2013.109 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 17 May 2013 |  |  |  | Ubiquitin-dependent recruitment of the Bloom Syndrome helicase upon replication stress is required to suppress homologous recombination The RNF8/RNF168/RAP80 ubiquitin signalling pathway acts not only at DNA double-strand breaks but also at stalled replication forks, where it mediates BLM helicase ubiquitination and recruitment. Shweta Tikoo, Vinoth Madhavan, Mansoor Hussain, Edward S Miller, Prateek Arora, Anastasia Zlatanou, Priyanka Modi, Kelly Townsend, Grant S Stewart and Sagar Sengupta The EMBO Journal (2013), 32, 1778 - 1792; 10.1038/emboj.2013.117 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 24 May 2013 |  | | Advertisement |  | Take part in our reader survey for a chance to win a MacBook Air
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