Nature Reviews Molecular Cell Biology contents July 2013 Volume 14 Number 7

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TABLE OF CONTENTS
July 2013 Volume 14 Number 7
Impact Factor 39.123 *	In this issue Research Highlights Reviews Perspectives Also this month Featured article: Post-translational modifications  Featured article: The mechanisms of Hedgehog signalling and its roles in development and disease James Briscoe & Pascal P. Thérond
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RESEARCH HIGHLIGHTS Top Development: PTEN regulates junction dynamics p399 | doi:10.1038/nrm3610 PTEN promotes elongation of cell junctions during wing morphogenesis. PDF DNA repair: A sensor for chromatin damage p400 | doi:10.1038/nrm3603 KAT5 Tyr phosphorylation senses chromatin damage and couples this to ATM activation. PDF Meiosis: A kinesin on foreign tracks p400 | doi:10.1038/nrm3604 A previously undescribed kinesin coordinates the interaction between microtubules and F-actin to ensure a faithful cytokinesis. PDF Cell adhesion: Integrating the integrin response p401 | doi:10.1038/nrm3605 Cooperation between α5β1 and αv integrins optimizes the response to fibronectin. PDF IN THE NEWS The return of ES cells p402 | doi:10.1038/nrm3600 Human embryonic stem cells have been generated through somatic cell nuclear transfer. PDF Autophagy: Kinase crosstalk through beclin 1 p402 | doi:10.1038/nrm3608 ULK1 activates VPS34 by phosphorylating beclin 1 during autophagy induction. PDF Post-translational modifications: Breaking linear chains p402 | doi:10.1038/nrm3612 Gumby and OTULIN encode a conserved DUB that specifically cleaves linear ubiquitin chains. PDF JOURNAL CLUB The biological meaning of the UPR p404 | doi:10.1038/nrm3606 The identification of XBP1 as the target of IRE1α in the UPR. PDF Cell adhesion: Extracellular bonds p404 | doi:10.1038/nrm3607 Secreted QSOX1 is required for the incorporation of laminin into the extracellular matrix. PDF IN BRIEF RNA decay: NMD broadens its reach | Post-translational modification: Setting limits on protein folding | Protein metabolism: pH power over the proteasome PDF Molecular Cell Biology JOBS of the week PhD Studentship - Integration of Microfluidic Cell Culture with NMR Spectroscopy for Correlation Metabolomics University of Southampton - Chemistry Senior Research Scientist in Stem Cell Biology Stanford University School of Medicine Laboratory Technician Stem Cell The Nestlé Institute of Health Sciences (NIHS) Postdoctoral Researcher in Bone Biology KU Leuven Chemical Biology in Cellular and Molecular Medicine University of Leuven (Belgium) More Science jobs from Molecular Cell Biology EVENT Molecular Medicine Congress 03.09.13 Frankfurt, Germany More science events from
REVIEWS		Top
Functions of cofilin in cell locomotion and invasion Jose Javier Bravo-Cordero, Marco A. O. Magalhaes, Robert J. Eddy, Louis Hodgson & John Condeelis p405 | doi:10.1038/nrm3609 Cofilin severing activity can generate free actin filament ends that are accessible for F-actin polymerization and depolymerization. The combination of structural data for filament severing with recently discovered mechanisms for cofilin activation in migrating cells is increasing our understanding of how cofilin activity affects cell behaviour. Abstract | Full Text | PDF | Supplementary information
The mechanisms of Hedgehog signalling and its roles in development and disease James Briscoe & Pascal P. Thérond p418 | doi:10.1038/nrm3598 The founding member of the Hedgehog (HH) family of secreted proteins was cloned two decades ago. The mechanism of HH signalling is incomplete, but insight has been gained into the function of lipidation in ligand secretion and transport, as well as into key components of the signalling pathway. Abstract | Full Text | PDF
Integrin inactivators: balancing cellular functions in vitro and in vivo Daniel Bouvard, Jeroen Pouwels, Nicola De Franceschi & Johanna Ivaska p432 | doi:10.1038/nrm3599 Traditionally, the integrin activity status was thought to be regulated by activators (talin and kindlin), with integrins passively adopting an inactive state. However, it is now emerging that the integrin activity state is dynamically regulated, with inactivators (SHARPIN, ICAP1 and filamin) having a key role in dampening integrin function in different cellular contexts. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
OPINION Article series: Post-translational modifications Macrodomain-containing proteins: regulating new intracellular functions of mono(ADP-ribosyl)ation Karla L. H. Feijs, Alexandra H. Forst, Patricia Verheugd & Bernhard Lüscher p445 | doi:10.1038/nrm3601 The function and regulation of poly(ADP-ribosyl)ation is partially understood. By contrast, little is known about intracellular mono(ADP-ribosyl)ation (MARylation) by ADP-ribosyl transferases. Recent findings indicate that MARylation regulates signalling and transcription by modifying key components in these processes, and that specific macrodomain-containing proteins 'read' and 'erase' this modification. Abstract | Full Text | PDF
OPINION A self-organization framework for symmetry breaking in the mammalian embryo Sebastian Wennekamp, Sven Mesecke, Francois Nédélec & Takashi Hiiragi p454 | doi:10.1038/nrm3602 Early mammalian blastocyst patterning involves symmetry breaking leading to lineage segregation. The classic models of lineage segregation cannot account for recent experimental data, and a new framework that regards the early mammalian embryo as a self-organizing system is put forward to explain these observations. Abstract | Full Text | PDF | Supplementary information
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