Nature Reviews Genetics Contents July 2013 Volume 14 Number 7 pp 442-515

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TABLE OF CONTENTS
July 2013 Volume 14 Number 7		Advertisement
Impact Factor 38.075 *	In this issue Research Highlights Ethics Watch Reviews Perspectives Also this month Featured article: Non-coding RNA Applications of next-generation sequencing Genome-wide association studies  Featured article: Alternative cleavage and polyadenylation: extent, regulation and function Ran Elkon, Alejandro P. Ugalde & Reuven Agami	Webinar on high throughput pharmacogenetic analysis of key ADME/T biomarkers • Wednesday June 26. • Register now for: 8AM PST or 4PM PST • Measurement, analysis and reporting of SNPs, INDELs and CNVs in 36 key genes related to ADME/T including CYP2C9, CYP2C19, CYP2D6, and UGT1A1
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RESEARCH HIGHLIGHTS Top Gene expression: Time flies thanks to Pol II pausing p441 | doi:10.1038/nrg3514 PDF Evo-Devo: Flowering form p442 | doi:10.1038/nrg3516 PDF Ageing: An ageing balancing act p442 | doi:10.1038/nrg3517 PDF Development: Zebrafish early methylomes p443 | doi:10.1038/nrg3515 PDF Genomics: Sprucing up forest tree genomics p444 | doi:10.1038/nrg3518 PDF IN BRIEF Evolution: Reconstructing essentiality | Epigenetics: Mechanistic insight into epigenetic inheritance | Complex disease: Limited role of rare variants in autoimmunity | Gene regulation: Better screening for alternative splicing regulators | Complex traits: Genetic maps for sequenced rats | Telomeres: Telomere length measurement in single cells | Gene regulation: mRNA decay factors regulate transcription | Chromosome biology: Nonrandom chromatid segregation in stem cells PDF Genetics JOBS of the week Postdoctoral Research Fellow Memorial Sloan-Kettering Cancer Center (MSKCC) Postdoctoral Researchers, PhD Positions and Senior Bioinformatician at the Max Planck Institutes of Biochemistry and Neurobiology Max Planck Institutes of Biochemistry and Neurobiology Scientific Programmer European Bioinformatics Institute Post-Doctoral Fellow (W Wang) Pancreatic Beta Cell Regeneration and Survival Oklahoma Medical Research Foundation (OMRF) Professor, Reader, Senior Lecturer or Lecturer Imperial College of London More Science jobs from Genetics EVENT Mouse Molecular Genetics 18.09.13 Cambridge, UK More science events from
ETHICS WATCH		Top
Forensic familial searching: scientific and social implications Nanibaa' A. Garrison, Rori V. Rohlfs & Stephanie M. Fullerton p445 | doi:10.1038/nrg3519 Familial searching in forensic genetic testing is raising concerns in the United States. Full Text | PDF
REVIEWS		Top
Article series: Non-coding RNA Argonaute proteins: functional insights and emerging roles Gunter Meister p447 | doi:10.1038/nrg3462 Argonaute proteins are vital components of small-RNA-guided modes of gene regulation. Recent studies have provided important details about classical modes of Argonaute function, such as their structure and loading with small RNAs, and have also revealed unexpected roles in other cellular functions. Abstract | Full Text | PDF
Article series: Applications of next-generation sequencing Sequencing studies in human genetics: design and interpretation David B. Goldstein, Andrew Allen, Jonathan Keebler, Elliott H. Margulies, Steven Petrou, Slavé Petrovski & Shamil Sunyaev p460 | doi:10.1038/nrg3455 Next-generation sequencing is now poised for the discovery of genetic variants involved in common and rare diseases. Here, the authors present considerations for the workflow of these studies in order to identify true associations of disease and mutation. Abstract | Full Text | PDF | Supplementary information
Genomic and epigenetic insights into the molecular bases of heterosis Z. Jeffrey Chen p471 | doi:10.1038/nrg3503 Heterosis, also known as hybrid vigour, is an intriguing phenomenon that has particularly important implications for agriculture. The molecular basis of this vigour is poorly understood, but progress is being made through the use of genomic, transcriptomic and epigenomic approaches. Abstract | Full Text | PDF
Article series: Genome-wide association studies Pleiotropy in complex traits: challenges and strategies Nadia Solovieff, Chris Cotsapas, Phil H. Lee, Shaun M. Purcell & Jordan W. Smoller p483 | doi:10.1038/nrg3461 Modern genomic studies are revealing widespread associations between single genetic variants and multiple distinct traits, including diseases. This Review discusses the biological underpinnings of such pleiotropy and the available bioinformatic tools for the detection and characterization of these effects, as well as the implications for understanding human disease. Abstract | Full Text | PDF
Alternative cleavage and polyadenylation: extent, regulation and function Ran Elkon, Alejandro P. Ugalde & Reuven Agami p496 | doi:10.1038/nrg3482 Recent advances have allowed the genomic characterization of the extent and regulation of alternative polyadenylation. Here, the biological processes with which alternative polyadenylation has been associated, the mechanisms of its regulation and its involvement in disease are discussed. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Article series: Genome-wide association studies Pitfalls of predicting complex traits from SNPs Naomi R. Wray, Jian Yang, Ben J. Hayes, Alkes L. Price, Michael E. Goddard & Peter M. Visscher p507 | doi:10.1038/nrg3457 The data from genome-wide association studies can be applied to genotype data to predict the phenotype of a complex trait. Here the authors discuss the potential pitfalls of such analyses and the inherent limitations of the method. Abstract | Full Text | PDF | Supplementary information
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*2011 Journal Citation Report (Thomson Reuters, 2012)

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