Nature Biotechnology Contents: Volume 31 pp 467 - 570

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Apply online today or call 919-405-2248 * 866-293-6094 Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement Combining open-access publishing with a powerful networking platform. The Frontiers publication process and Research Networking Platform allow you to build your own scientific profiles while following the work of colleagues, mentors and your science heroes. Connect with your community today   Editorial Top What price affordable access?   p467 doi:10.1038/nbt.2615 To prevent a popular backlash against the spiraling prices of US prescription medicines, industry needs to do more to address out-of-pocket expenses for patients. News Top SGLT2 inhibitors enter crowded diabetes space   pp469 - 470 Aaron Bouchie doi:10.1038/nbt0613-469 Million veterans sequenced   p470 Josh P Roberts doi:10.1038/nbt0613-470 Amgen announces oncolytic virus shrinks tumors   pp471 - 472 Cormac Sheridan doi:10.1038/nbt0613-471 Family offices bolster early-stage financing   pp473 - 475 Melanie Senior doi:10.1038/nbt0613-473 Japanese pharmas unite for poorest   p474 David Cyranoski doi:10.1038/nbt0613-474 San Diego survives Amylin shock   p475 Brian Orelli doi:10.1038/nbt0613-475 AstraZeneca juggernaut heads for Cambridge   pp476 - 478 Nuala Moran doi:10.1038/nbt0613-476 DuPont pays $1.75 for Monsanto next-gen traits   p477 Emma Dorey doi:10.1038/nbt0613-477 Around the world in a month   p478 doi:10.1038/nbt0613-478 US Congress moves to 'protect' GM crop plantings   p479 Laura DeFrancesco doi:10.1038/nbt0613-479 $350 million in new funding for brain research   p480 Jeffrey L Fox doi:10.1038/nbt0613-480 Editors' Pick Galecto Biotech   p481 Ken Garber doi:10.1038/nbt0613-481 By targeting a sugar-binding protein, a Swedish startup hopes to provide new lung fibrosis treatments. Data Page Drug pipeline: 1Q13   p482 Laura DeFrancesco doi:10.1038/nbt.2607 News Feature Inducing translation   pp483 - 486 Ken Garber doi:10.1038/nbt.2602 The field of induced pluripotent stem cells is barely seven years old, but already three groups are close to launching clinical trials. Ken Garber looks into the prospects and perils. Bioentrepreneur Top Building a business A personal account of translating discoveries in an academic lab   pp487 - 489 Robert Langer doi:10.1038/nbt.2609 The Langer Lab's secret sauce   p490 Aimee L Hamilton doi:10.1038/nbt.2608 SciCafé Startups on the menu   p490 doi:10.1038/nbt0613-490 Opinion and Comment Top Correspondence The cancer megafund: a catalyst for disruptive innovation   pp491 - 492 Jay M Tenenbaum doi:10.1038/nbt.2605 The cancer megafund: determinants of success   pp492 - 494 Nicholas F Marko doi:10.1038/nbt.2603 The cancer megafund: mathematical modeling needed to gauge risk   p494 Francois-Henri Boissel doi:10.1038/nbt.2604 Literature access and destruction   p495 Daniel Simeon-Dubach doi:10.1038/nbt.2583 Publications and patents in corporate venture-backed biotech   pp495 - 497 Elisa Alvarez-Garrido and Gary Dushnitsky doi:10.1038/nbt.2569 What the French ban of Bt MON810 maize means for science-based risk assessment   pp498 - 500 Marcel Kuntz, John Davison and Agnes E Ricroch doi:10.1038/nbt.2613 Patents Patent portfolios for biotech inventions   pp501 - 503 Shyh-Jen Wang doi:10.1038/nbt.2598 Choosing the right patent portfolio strategy will aid in protecting your valuable biotech intellectual property. News and Views Top Identifying the metastatic seeds of breast cancer   pp504 - 505 Angera H Kuo and Michael F Clarke doi:10.1038/nbt.2599 Two studies show that circulating tumor cells from breast cancer patients give rise to metastases in mice. See also: Research by Baccelli et al. Cancer metabolism in breadth and depth   pp505 - 507 Matthew G H Chun and Reuben J Shaw doi:10.1038/nbt.2611 Recent advances in understanding the altered metabolism of tumor cells are yielding new therapeutic leads. See also: Computational Biology by Hu et al. All charged up about implanted biomaterials   pp507 - 509 David W Grainger doi:10.1038/nbt.2600 A zwitterionic polymer hinders the foreign-body response that leads to fibrotic encapsulation of implants. See also: Research by Zhang et al. Research Highlights   p509 doi:10.1038/nbt.2610 Biotechnology JOBS of the week Senior Expert Pathologist (M / F) Roche Diagnostics GmbH Postdoctoral Associate in Systems Biology and Microbial Evolution Tagkopoulos Lab at the University of California, Davis Scientist Position Euroscreen S.A. Postdoctoral Scholar Department of Bioengineering, Rice University More Science jobs from Biotechnology EVENT Plant Genomes & Biotechnology: from genes to networks July 12, 2013 Cold Spring Harbor, US More science events from Research Top Review Insect resistance to Bt crops: lessons from the first billion acres   pp510 - 521 Bruce E Tabashnik, Thierry Brevault and Yves Carriere doi:10.1038/nbt.2597 Delineating four categories of field-evolved resistance of pests to Bt crops, through analysis of 77 studies carried out in five continents from 1996 to 2012, should inform future pest management strategies. Computational Biology Top Analysis Heterogeneity of tumor-induced gene expression changes in the human metabolic network   pp522 - 529 Jie Hu, Jason W Locasale, Jason H Bielas, Jacintha O'Sullivan and Kieran Sheahan et al. doi:10.1038/nbt.2530 Analysis of gene expression data from 22 tumor types reveals differences in how the metabolic network is perturbed in cancer. See also: News and Views by Chun & Shaw Research Top Brief Communications TALEN-mediated editing of the mouse Y chromosome   pp530 - 532 Haoyi Wang, Yueh-Chiang Hu, Styliani Markoulaki, G Grant Welstead and Albert W Cheng et al. doi:10.1038/nbt.2595 Targeted nucleases succeed in modifying the Y chromosome that has been recalcitrant to traditional genome engineering methods. Articles Genome sequences of rare, uncultured bacteria obtained by differential coverage binning of multiple metagenomes   pp533 - 538 Mads Albertsen, Philip Hugenholtz, Adam Skarshewski, Kare L Nielsen and Gene W Tyson et al. doi:10.1038/nbt.2579 Genome assembly for rare, uncultured bacteria is improved by mining deep metagenome sequencing data. Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay   pp539 - 544 Irene Baccelli, Andreas Schneeweiss, Sabine Riethdorf, Albrecht Stenzinger and Anja Schillert et al. doi:10.1038/nbt.2576 A xenograft assay facilitates identification of metastasis-initiating cells in the blood of individuals with breast cancer. See also: News and Views by Kuo & Clarke viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia   pp545 - 552 El-ad David Amir, Kara L Davis, Michelle D Tadmor, Erin F Simonds and Jacob H Levine et al. doi:10.1038/nbt.2594 A new tool to visualize high-dimensional single-cell data, when integrated with mass cytometry, reveals phenotypic heterogeneity of human leukemia. Letter Zwitterionic hydrogels implanted in mice resist the foreign-body reaction   pp553 - 556 Lei Zhang, Zhiqiang Cao, Tao Bai, Louisa Carr and Jean-Rene Ella-Menye et al. doi:10.1038/nbt.2580 Zwitterionic hydrogels may be a useful biocompatible material, as they resist collagen capsule formation yet promote angiogenesis after implantation in mice. See also: News and Views by Grainger Resources A large synthetic peptide and phosphopeptide reference library for mass spectrometry-based proteomics   pp557 - 564 Harald Marx, Simone Lemeer, Jan Erik Schliep, Lucrece Matheron and Shabaz Mohammed et al. doi:10.1038/nbt.2585 Mass spectra for >100,000 synthetic peptides provide a basis for improving proteomics experiments and analysis algorithms. Corrigenda Lessons from human teratomas to guide development of safe stem cell therapies   p565 J J Cunningham, T M Ulbright, M F Pera and L H Looijenga doi:10.1038/nbt0613-565a Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis   p565 Daniel R Getts, Aaron J Martin, Derrick P McCarthy, Rachael L Terry and Zoe N Hunter et al. doi:10.1038/nbt0613-565b Life sciences venture capital in emerging markets   p565 Justin Chakma, Stephen M Samut and Ajay Agrawal doi:10.1038/nbt0613-565c Giving voice to India's entrepreneurs   p565 Gayatri Saberwal doi:10.1038/nbt0613-565d Editor's Pick: Orphazyme   p565 Ken Garber doi:10.1038/nbt0613-565e Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing   p566 Gang Fang, Diana Munera, David I Friedman, Anjali Mandlik and Michael C Chao et al. doi:10.1038/nbt0613-565f Industry pursues co-stimulatory receptor immunomodulators to treat cancer   p566 Cormac Sheridan doi:10.1038/nbt0613-565g Erratum Biotech's wellspring: the health of private biotech in 2012   p566 Brady Huggett doi:10.1038/nbt0613-565h Careers and Recruitment Top Staying happy and productive as a mid-career professional   pp567 - 568 Claire T Driscoll doi:10.1038/nbt.2606 Continuous learning, even for reasonably experienced and PhD-level workers, is both valued and expected. People People   p570 doi:10.1038/nbt.2617 Top Advertisement Nature Methods Focus on Mapping the Brain www.nature.com/nmeth/focus/brainmapping Experts discuss the different technologies needed to obtain anatomical and functional brain maps across species, and discuss the importance of assembling these maps and what will be needed beyond them, to understand the functioning of the brain. Produced with support from: Carl Zeiss Microscopy, Hamamatsu Corporation, LaVision BioTec, TissueVision, Inc. and Chroma Technology Corp   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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