Drug Discovery@nature.com 31 May 2013

TABLE OF CONTENTS 31 May 2013 News Analysis Research Highlights Research & Reviews Careers Nature Reviews Drug Discovery is on Twitter Advertisement Nature Structural & Molecular Biology FOCUS ON EPIGENETIC DYNAMICS This Focus explores emerging themes and the functional implications of epigenetic dynamics. Access the Focus for FREE at: www.nature.com/nsmb/focus/epigeneticdynamics This Focus is freely available thanks to support from Active Motif   News Top Immunotherapy's cancer remit widens doi:10.1038/497544a Combination therapies hold great promise, but at what cost? Full Text Studies cast doubt on cancer drug as Alzheimer's treatment doi:10.1038/nature.2013.13058 Independent researchers fail to replicate bexarotene results. Full Text Scientists discover molecular trigger for itch doi:10.1038/nature.2013.13061 Identification of distinct neural circuit distinguishes the sensation from pain. Full Text New avian flu readily transmits in key animal model doi:10.1038/nature.2013.13062 Emerging H7N9 virus easily jumps between ferrets even though there is no evidence for human-to-human transmission. Full Text Analysis Top IRS audit for tumors doi:10.1038/scibx.2013.478 A partnership has discovered small molecules that target insulin receptor substrates 1 and 2, which sit downstream of the cancer-associated insulin-like growth factor-1 receptor. The compounds have been licensed to NovoTyr. Full Text Commercial prospects for genomic sequencing technologies doi:10.1038/nrd4006 This article analyses the evolution of the market for genomic sequencing technologies in the light of major reductions in sequencing costs and time, and the growth in potential pharmacogenomics applications. Full Text Research Highlights Top Tumour vaccination: Devil in the details of adjuvant choice doi:10.1038/nrd4014 The widespread use of incomplete Freud's adjuvant in cancer vaccination protocols might be to blame for lack of effectiveness. Full Text Kinase inhibitors: Double duty doi:10.1038/nrd4011 A new mechanism of action for ATP-competitive kinase inhibitors, an important class of anticancer agents, could have implications for the way these inhibitors are used in the clinic. Full Text Infectious diseases: Novel agents fight flu infection doi:10.1038/nrd4013 Two papers have recently identified novel inhibitors of influenza virus replication that might overcome limitations of existing drugs. Full Text Research & Reviews Top Platforms for antibiotic discovery doi:10.1038/nrd3975 Re-establishing effective platforms for antibiotic discovery is crucial for combating antibiotic resistance. This article discusses the lessons learned from the golden era of antibiotic discovery, and proposes strategies to create new platforms or revitalize old ones. Full Text Implementing personalized cancer genomics in clinical trials doi:10.1038/nrd3979 This article explores how genomic information can be used in the design of clinical trials for molecularly targeted anticancer drugs as well as for the development of new biomarkers. Full Text Role of the gut microbiota in immunity and inflammatory disease doi:10.1038/nri3430 Understanding the interaction of the microbiota with pathogens and the host might provide new insights into the pathogenesis of disease, as well as novel avenues for preventing and treating intestinal and systemic disorders. Full Text Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group doi:10.1038/nchembio.1223 Specific inhibitors of class IIa HDACs, based on a new zinc-binding scaffold, offer chemical probes to explore the biological function and potential druggability of this enzyme subclass. Full Text Drug Discovery JOBS of the week Research Associate - Compound Management Novartis Institute for Tropical Diseases Pte Ltd, Singapore Early Career Scientists and Engineers: Computational Biochemistry Research Group D. E. Shaw Research Bioinformatician (M / F) German Cancer Research Center (DKFZ) Post Doctoral Fellow Aaron Diamond AIDS Research Center Scientist in Neurodevelopmental Diseases F. Hoffmann-La Roche AG More Science jobs from Drug Discovery EVENT Pediatric Drug Development 08.07.13 London, UK More science events from Careers Top Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. Full Text Top Advertisement SciBX: Science-Business eXchange is a weekly publication that identifies and analyzes the most important translational research articles from over 40 journals. Find out which papers have real scientific and commercial potential, and why. Recommend SciBX to your library today.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant) For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our customer feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.