Drug Discovery@nature.com 22 March 2013

TABLE OF CONTENTS 22 March 2013 News Analysis Research Highlights Research & Reviews Careers Nature Reviews Drug Discovery is on Twitter Advertisement We know you're busy, so let the research come to you Scientific Reports is an open access journal that publishes research across all areas of the natural sciences. New papers are published daily. Stay updated with our latest content. Choose to receive a weekly round-up of all content published in the last seven days or monthly subject specific alerts. Sign up today.   News Top Painkillers mobilize blood stem cells doi:10.1038/nature.2013.12600 Aspirin-related drugs suggest a way towards more effective stem-cell transplants. Full Text Blockbuster dreams for Pfizer's CDK inhibitor doi:10.1038/nbt0313-187a Dramatic clinical data for Pfizer's leading CDK4/6 inhibitor palbociclib has rekindled interest in the concept of blocking cell cycle progression to stop cancer cell growth. Full Text Blood test tracks cancer doi:10.1038/nature.2013.12598 Monitoring tumour DNA shows promise for following progress of disease. Full Text An Audience With: Chris Austin doi:10.1038/nrd3960 Chris Austin, Director of the National Center for Advancing Translational Sciences, discusses his plans to tackle the “tragedy of the commons” drug discovery problems. Full Text Analysis Top Squaring the RNA circle doi:10.1038/scibx.2013.229 Two teams have shown that circular RNAs are widely expressed in humans and have regulatory functions, although their biomedical relevance remains to be established. Full Text Stem cell therapy market doi:10.1038/nrd3953 Products based on stem cells show promise in diverse therapeutic areas, including cardiovascular and autoimmune diseases. This article analyses the late-stage pipeline of stem cell therapies and provides a market overview. Full Text Research Highlights Top Cancer: Double-pronged approach to combat mutant KRAS doi:10.1038/nrd3969 KRAS-mutated tumour cells treated with MEK inhibitors are particularly sensitive to the simultaneous inhibition of the anti-apoptotic protein B cell lymphoma XL. Full Text Regenerative disorders: Notching up hearing doi:10.1038/nrd3964 Pharmacological inhibition of Notch signalling can partially restore hearing in mice exposed to acoustic trauma. Full Text Peptides: Activating autophagy doi:10.1038/nrd3970 A potent autophagy-inducing peptide shows promising efficacy in several infectious diseases and in the clearance of protein aggregates in neurodegenerative diseases. Full Text Research & Reviews Top The role of tumour–stromal interactions in modifying drug response: challenges and opportunities doi:10.1038/nrd3870 This review discusses the impact of the tumour microenvironment on tumour cell signalling, survival and drug response, and describes preclinical models to help account for this impact in anticancer drug discovery. Full Text The placebo response in medicine: minimize, maximize or personalize? doi:10.1038/nrd3923 This perspective discusses how the placebo response could be used in drug development and clinical practice to help allow the most desirable outcome to be attained in each setting. Full Text Inhibition of α-helix-mediated protein-protein interactions using designed molecules doi:10.1038/nchem.1568 This review discusses the relevance of protein–protein interactions, particularly those medicated by α-helices, to chemical biology and drug discovery, with a focus on designing inhibitors. Full Text Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis doi:10.1038/nm.2989 Inhibiting human epididymis protein-4 reduced fibrosis in three different mouse models of renal disease, suggesting that it is a new therapeutic target. Full Text Drug Discovery JOBS of the week Postdoctoral Fellow in structure-based drug design by NMR EMBL (European Molecular Biology Laboratory) Associate Director - Small Molecule Oncology Drug Discovery Janssen (Johnson & Johnson Group) Postdoctoral Fellow, Medicinal Chemistry The Centre for Drug Research and Development Medicinal Chemist Selvita More Science jobs from Drug Discovery EVENT Resources for Computational Drug Discovery 09.12.13 Cambridge - UK More science events from Careers Top Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. 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