Drug Discovery@nature.com 15 March 2013

TABLE OF CONTENTS 15 March 2013 News Analysis Research Highlights Research & Reviews Careers Nature Reviews Drug Discovery is on Twitter Advertisement Nature Immunology ANIMATION: IMMUNOLOGY IN THE GUT MUCOSA Nature Immunology in collaboration with Arkitek Studios have produced an animation unravelling the complexities of mucosal immunology in health and disease. View the Animation for FREE at: www.nature.com/ni/multimedia/mucosal Produced with support from Janssen Pharmaceutical Companies of Johnson & Johnson   News Top Red wine's link to health gains support doi:10.1038/nature.2013.12563 Evidence found for resveratrol’s mechanism of action. Full Text Industry pursues co-stimulatory receptor immunomodulators to treat cancer doi:10.1038/nbt0313-181 The emergence of two new start-ups, combined with an uptick in big pharma deal-making, is further evidence that cancer immunotherapy has now become a major theme in cancer drug discovery. Full Text Antisense battles small molecule for slice of rare lipid disorder market doi:10.1038/nbt0313-179 The US FDA has approved two new lipid-lowering drugs to treat homozygous familial hypercholesterolemia: the small-molecule lomitapide and the antisense agent mipomersen. Full Text Salt linked to autoimmune diseases doi:10.1038/nature.2013.12555 Nanowires show sodium chloride may cause harmful T-cell growth. Full Text Analysis Top Assaying 2-HG's function doi:10.1038/scibx.2013.205 Researchers have shown that 2-hydroxyglutarate, a known marker for various cancers, directly drives leukemic transformation. Blocking its overproduction with a small molecule from Agios could reverse the leukogenic effect. Full Text Stem cell therapy market doi:10.1038/nrd3953 Products based on stem cells show promise in diverse therapeutic areas, including cardiovascular and autoimmune diseases. This article analyses the late-stage pipeline of stem cell therapies and provides a market overview. Full Text Research Highlights Top Cancer: Double-pronged approach to combat mutant KRAS doi:10.1038/nrd3969 KRAS-mutated tumour cells treated with MEK inhibitors are particularly sensitive to the simultaneous inhibition of the anti-apoptotic protein B cell lymphoma XL. Full Text Regenerative disorders: Notching up hearing doi:10.1038/nrd3964 Pharmacological inhibition of Notch signalling can partially restore hearing in mice exposed to acoustic trauma. Full Text Peptides: Activating autophagy doi:10.1038/nrd3970 A potent autophagy-inducing peptide shows promising efficacy in several infectious diseases and in the clearance of protein aggregates in neurodegenerative diseases. Full Text Research & Reviews Top The role of tumour–stromal interactions in modifying drug response: challenges and opportunities doi:10.1038/nrd3870 This review discusses the impact of the tumour microenvironment on tumour cell signalling, survival and drug response, and describes preclinical models to help account for this impact in anticancer drug discovery. Full Text The placebo response in medicine: minimize, maximize or personalize? doi:10.1038/nrd3923 This perspective discusses how the placebo response could be used in drug development and clinical practice to help allow the most desirable outcome to be attained in each setting. Full Text Inhibition of α-helix-mediated protein–protein interactions using designed molecules doi:10.1038/nchem.1568 This review discusses the relevance of protein–protein interactions, particularly those medicated by α-helices, to chemical biology and drug discovery, with a focus on designing inhibitors. Full Text Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis doi:10.1038/nm.2989 Inhibiting human epididymis protein-4 reduced fibrosis in three different mouse models of renal disease, suggesting that it is a new therapeutic target. Full Text Drug Discovery JOBS of the week Drug Development for Parasites http://aroianlab.ucsd.edu Postdoctoral Positions in Drug Discovery Research (1-2) Shanghai Jiaotong University Screening Desert Plants for Drug Discovery Rivka Ofir Drug Design and Pharmacology, Faculty of Health and Medical Sciences University of Copenhagen More Science jobs from Drug Discovery EVENT Resources for Computational Drug Discovery 09.12.13 Cambridge - UK More science events from Careers Top Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. 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