The EMBO Journal - Table of Contents alert Volume 32 Issue 3

TABLE OF CONTENTS 06 February 2013 | Volume 32, Issue 3 Have you seen? Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement The winner of the 2013 FEBS | EMBO Women in Science Award is Geneviève Almouzni from the Institut Curie in Paris, France. She received the award in recognition of her outstanding research on chromatin dynamics and her commitment to mentoring women pursuing a career in science. The EMBO Journal congratulates Geneviève Almouzni, editorial advisory board member, for her achievements.   Have you seen? Top PIPing on lysosome tubes PI4 kinase IIIβ and PI(4)P on lysosomes control sorting from the lysosome, and they are required for autophagic lysosome reformation under normal conditions and after nutrient deprivation. Nicholas T Ktistakis and Sharon A Tooze The EMBO Journal (2013), 32, 315 - 317; 10.1038/emboj.2012.355 Abstract | Full text | PDF | Related article Published online: 11 January 2013 The simplest explanation: passive DNA demethylation in PGCs During primordial germ cell (PGC) specification, global epigenetic modifications restructure the genome in a coordinated fashion. Novel evidence supports passive erasure, rather than active mechanisms, for the removal of epigenetic marks. Zachary D Smith and Alexander Meissner The EMBO Journal (2013), 32, 318 - 321; 10.1038/emboj.2012.349 Abstract | Full text | PDF | Related article Published online: 08 January 2013 Novel tricks played by the second messenger c-di-GMP in bacterial biofilm formation Regulation of biofilm formation involves an unexpected new structural role for the major bacterial signalling molecule cyclic di-GMP. Regine Hengge The EMBO Journal (2013), 32, 322 - 323; 10.1038/emboj.2012.351 Abstract | Full text | PDF | Related article Published online: 08 January 2013 Articles Top The lipid kinase PI4KIIIβ preserves lysosomal identity The recycling of proteins from lysosomes remains ill understood. The lipid kinase PI4KIIIβ prevents continuous lysosomal efflux and assures efficient recycling of lysosomal material. Loss of PI4KIIIβ activity leads to formation of abnormal tubular structures on lysosomes. Sunandini Sridhar, Bindi Patel, David Aphkhazava, Fernando Macian, Laura Santambrogio, Dennis Shields and Ana Maria Cuervo The EMBO Journal (2012), 32, 324 - 339; 10.1038/emboj.2012.341 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 21 December 2012 Subject Categories: Membranes and Transport | Signal Transduction Replication-coupled passive DNA demethylation for the erasure of genome imprints in mice In vivo examination of primordial germ cells (PGCs) favours a ‘replication-coupled passive demethylation’ mechanism for the erasure of DNA-methyl marks. This challenges current notions of active demethylation pathways. Saya Kagiwada, Kazuki Kurimoto, Takayuki Hirota, Masashi Yamaji and Mitinori Saitou The EMBO Journal (2012), 32, 340 - 353; 10.1038/emboj.2012.331 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 14 December 2012 Subject Categories: Genome Stability and Dynamics | Development Allosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein–protein interaction Biofilm formation allows pathogenic bacteria to evade detection by the immune system. The second messenger cyclic di-GMP bridges protein subunits of the poly-GlcNAc synthesis machinery to stimulate synthesis of this major biofilm component. Samuel Steiner, Christian Lori, Alex Boehm and Urs Jenal The EMBO Journal (2012), 32, 354 - 368; 10.1038/emboj.2012.315 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 30 November 2012 Subject Categories: Membranes and Transport | Signal Transduction | Microbiology and Pathogens Structural basis for conformational switching and GTP loading of the large G protein atlastin Novel crystal structures of atlastin reveal the complete cycle of dynamin superfamily GTPases for membrane remodelling at the ER. Complementary kinetic and functional experiments elucidate mechanisms relevant for atlastin-associated hereditary neurodegenerative diseases. Laura J Byrnes, Avtar Singh, Kylan Szeto, Nicole M Benvin, John P O’Donnell, Warren R Zipfel and Holger Sondermann The EMBO Journal (2013), 32, 369 - 384; 10.1038/emboj.2012.353 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 18 January 2013 Subject Categories: Membranes and Transport | Signal Transduction | Structural Biology In vitro reconstitution of Cascade-mediated CRISPR immunity in Streptococcus thermophilus Bacterial CRISPR systems confer immunity by degrading invading DNA species. Reconstituting the Type I CRISPR Cascade complex from S. thermophilus demonstrates the molecular basis for recognition and cleavage of DNA by the nuclease Cas3. Tomas Sinkunas, Giedrius Gasiunas, Sakharam P Waghmare, Mark J Dickman, Rodolphe Barrangou, Philippe Horvath and Virginijus Siksnys The EMBO Journal (2013), 32, 385 - 394; 10.1038/emboj.2012.352 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 18 January 2013 Subject Categories: RNA | Microbiology and Pathogens BRG1-mediated immune tolerance: facilitation of Treg activation and partial independence of chromatin remodelling Deletion of BRG1 in regulatory T cells (Tregs) impairs Treg activation and causes fatal autoimmune reactions, revealing an unexpected immune tolerance function of this otherwise proinflammatory chromatin-remodelling factor. Barbara H Chaiyachati, Anant Jani, Yisong Wan, Haichang Huang, Richard Flavell and Tian Chi The EMBO Journal (2013), 32, 395 - 408; 10.1038/emboj.2012.350 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 15 January 2013 Subject Categories: Chromatin and Transcription | Immunology A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors The yeast kinetochore receptors Cnn1 and Dsn1 employ a related peptide motif to recruit the microtubule-binding Ndc80 complex in a competitive, phosphorylation-regulated manner. Francesca Malvezzi, Gabriele Litos, Alexander Schleiffer, Alexander Heuck, Karl Mechtler, Tim Clausen and Stefan Westermann The EMBO Journal (2013), 32, 409 - 423; 10.1038/emboj.2012.356 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 18 January 2013 Subject Categories: Cell Cycle | Structural Biology CENP-T provides a structural platform for outer kinetochore assembly Structural insights into the interaction of the human centromeric protein CENP-T with the Ndc80 complex reveal how CDK phosphorylation regulates kinetochore protein assemblies. Tatsuya Nishino, Florencia Rago, Tetsuya Hori, Kentaro Tomii, Iain M Cheeseman and Tatsuo Fukagawa The EMBO Journal (2013), 32, 424 - 436; 10.1038/emboj.2012.348 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 18 January 2013 Subject Categories: Cell Cycle Dimerization of Sir3 via its C-terminal winged helix domain is essential for yeast heterochromatin formation Sir3 causes heterochromatic gene silencing through interactions with nucleosomes, which are facilitated by homo-dimerization via its conserved C-terminal tail. Mariano Oppikofer, Stephanie Kueng, Jeremy J Keusch, Markus Hassler, Andreas G Ladurner, Heinz Gut and Susan M Gasser The EMBO Journal (2013), 32, 437 - 449; 10.1038/emboj.2012.343 Abstract | Full text | PDF | Supp. info. Published online: 08 January 2013 Subject Categories: Chromatin and Transcription | Proteins Myb-domain protein Teb1 controls histone levels and centromere assembly in fission yeast Genome-wide binding and expression analyses reveal a putative telomere-binding protein as a master regulator of histone gene transcription and CenH3 incorporation. Luis P Valente, Pierre-Marie Dehé, Michael Klutstein, Sofia Aligianni, Stephen Watt, Jürg Bähler and Julia Promisel Cooper The EMBO Journal (2013), 32, 450 - 460; 10.1038/emboj.2012.339 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 11 January 2013 Subject Categories: Chromatin and Transcription | Cell Cycle Role of Saw1 in Rad1/Rad10 complex assembly at recombination intermediates in budding yeast The multifunctional Rad1/Rad10 does not have intrinsic structure-specific endonuclease properties, but can target single-strand annealing intermediates through a structure-specific cofactor. Fuyang Li, Junachao Dong, Robin Eichmiller, Cory Holland, Eugen Minca, Rohit Prakash, Patrick Sung, Eun Yong Shim, Jennifer A Surtees and Sang Eun Lee The EMBO Journal (2013), 32, 461 - 472; 10.1038/emboj.2012.345 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 08 January 2013 Subject Categories: Genome Stability and Dynamics Chtop is a component of the dynamic TREX mRNA export complex The TREX complex coordinates nuclear mRNA processing and export. Chtop is a novel TREX component that stimulates the helicase activity of Uap56 and mediates Nxf1 binding to dynamically remodel mRNP export complexes. Chung-Te Chang, Guillaume M Hautbergue, Matthew J Walsh, Nicolas Viphakone, Thamar B van Dijk, Sjaak Philipsen and Stuart A Wilson The EMBO Journal (2013), 32, 473 - 486; 10.1038/emboj.2012.342 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 08 January 2013 Subject Categories: RNA Advertisement EMBO - Transparency in Scientific Publishing The EMBO Journal has a fair and transparent process to rapidly publish your best science. Transparent - No confidential referee remarks - Published referee reports - Detailed decisions - Source Data published alongside figures Fair - Scooping protection - Pre-decision cross-referee commenting - Fixed bar for revisions - Fast process   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. 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