BioPharma Dealmakers A supplement to Nature Biotechnology and Nature Reviews Drug Discovery
The October 2012 issue of BioPharma Dealmakers showcases companies with partnering opportunities and contains a focus feature on those active in Neuro-partnering. This week, find out about how you can collaborate with Stempeutics.
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SciBx is a weekly publication that identifies and analyzes the most important translational research articles from over 40 journals. Find out which papers have real scientific and commercial potential, and why. Subscribe to SciBX and you won't miss the next big thing.
Cancer target selection pressure Joanne Kotz doi:10.1038/scibx.2013.128 An Institute of Cancer Research team has developed a computational algorithm that hones in on cancer targets with the desired mix of biological validation and druggability. The approach could help prioritize targets. Full Text | PDF
Statins for fragile X Lev Osherovich doi:10.1038/scibx.2013.129 MIT researchers have shown that the widely used cholesterol drug lovastatin can correct fragile X syndrome in mice. The findings add to a growing list of unconventional strategies for this common form of mental retardation. Full Text | PDF
Stressing out over depression and anxiety Tim Fulmer doi:10.1038/scibx.2013.130 Two teams have shown that enhanced glucocorticoid signaling in the brain triggers aberrant behavior in mouse models of depression and anxiety. The groups are now studying the mechanisms underlying the effect to determine whether blocking glucocorticoid signaling could treat neuropsychiatric diseases. Full Text | PDF
Tethered capsule endomicroscopy Tracey Baas doi:10.1038/scibx.2013.131 Massachusetts General Hospital researchers have created a tethered, capsule-size endoscope that can generate 3D microstructural images of the upper GI tract. The team used the device to image Barrett's esophagus in patients and has licensed the technology to NinePoint Medical. Full Text | PDF
MicroRNA-374a (miR-374a) doi:10.1038/scibx.2013.132 Patient sample and mouse studies suggest inhibiting miR-374a could help prevent or treat breast cancer metastasis. Full Text | PDF
BCL2-associated X protein (BAX); BCL2-antagonist/killer 1 (BAK1; BAK); B cell lymphoma 2 (BCL-2; BCL2); BCL3 homology domain 3 (BH3) doi:10.1038/scibx.2013.133 Structural studies have identified regions of BAX and BAK that could guide the development of a new class of BH3-mimetic drugs that directly trigger apoptosis and help treat cancer. Full Text | PDF
Prominin 1 (PROM1; CD133) doi:10.1038/scibx.2013.134 Mouse studies suggest oncolytic measles viruses engineered to target CD133 could help treat cancer. Full Text | PDF
Ras homolog gene family member A (RHOA); leukemia-associated Rho guanine nucleotide exchange factor (LARG) doi:10.1038/scibx.2013.135 In vitro studies identified a small molecule inhibitor of the interaction between LARG and RHOA that could help treat cancers. Full Text | PDF
BRAF doi:10.1038/scibx.2013.136 A study in mice suggests intermittent rather than continuous dosing of Zelboraf could prevent or delay drug resistance in patients with melanoma. Full Text | PDF
Angiotensinogen (AGT); angiotensin-converting enzyme (ACE) doi:10.1038/scibx.2013.137 Patient tissue and mouse studies suggest ACE inhibitors could help treat NSCLC in patients with angiotensin II–overexpressing tumors. Full Text | PDF
Serine/threonine kinase 11 (STK11; LKB1); K-Ras doi:10.1038/scibx.2013.138 Mouse and cell culture studies suggest the metformin analog phenformin could help treat K-Ras‒driven NSCLCs with LKB1 mutations. Full Text | PDF
Unknown doi:10.1038/scibx.2013.139 Cell culture and mouse studies suggest a diarylurea-based compound could help regenerate β cell mass and treat type 1 diabetes. Full Text | PDF
Dopamine signaling doi:10.1038/scibx.2013.143 Mouse studies suggest blocking neurotransmission of dopamine-sensing neurons could help treat neuropsychiatric disorders triggered by chronic stress. Full Text | PDF
Glucocorticoid receptor (GCCR); disrupted in schizophrenia 1 (DISC1) doi:10.1038/scibx.2013.144 Mouse studies suggest blocking the glucocorticoid receptor in the brain could help treat adult-onset neuropsychiatric disorders triggered by adolescent stress. Full Text | PDF
Ras; MAP kinase 3 (MAPK3; ERK-1); MAPK1 (ERK-2) doi:10.1038/scibx.2013.145 Studies in mice suggest lovastatin could help treat epilepsy in patients with fragile X syndrome. Full Text | PDF
High throughput small hairpin RNA–based genetic interaction mapping in human cells doi:10.1038/scibx.2013.146 A high throughput method to analyze genetic interactions in human cells could help identify new disease pathways and targets. Full Text | PDF
Protein translocation through an α-hemolysin–caseinolytic peptidase X homolog (ClpX) nanopore system doi:10.1038/scibx.2013.147 A method to translocate proteins through α-hemolysin nanopores could eventually enable nanopore-based protein sequencing. Full Text | PDF
Sensitizing bacteria to antibiotics by increasing reactive oxygen species (ROS) production doi:10.1038/scibx.2013.148 In silico prediction and in vitro screening could help identify targets that increase bacterial ROS production and improve the efficacy of marketed antibiotics. Full Text | PDF
Antiamyloid compounds that inhibit biofilm formation doi:10.1038/scibx.2013.149 In vitro studies suggest compounds that disrupt amyloid fibers could be useful for preventing biofilm formation. Full Text | PDF
Computational approach for prioritizing potential cancer targets doi:10.1038/scibx.2013.150 A computational approach that predicts the druggability of cancer-associated proteins could help prioritize targets in small molecule discovery programs. Full Text | PDF
Patient induced pluripotent stem (iPS) cell–derived cardiomyocytes as models for right ventricular dysplasia/cardiomyopathy doi:10.1038/scibx.2013.151 Cardiomyocytes generated from patient-derived iPS cells could help identify new treatments for right ventricular dysplasia/cardiomyopathy. Full Text | PDF
Adjuvant and antigen co-delivery with nickel-chelating lipid nanoparticles doi:10.1038/scibx.2013.152 Nickel-chelating lipid nanoparticles that co-deliver antigens and adjuvants could be useful for vaccine delivery. Full Text | PDF
Dissolving microneedle arrays for delivery of live adenovirus vaccines doi:10.1038/scibx.2013.153 A dissolvable microneedle array could be used for transdermal delivery of adenovirus vaccines. Full Text | PDF
Highly prevalent telomerase reverse transcriptase (TERT) promoter mutations in melanoma doi:10.1038/scibx.2013.154 Two independent studies identified highly prevalent mutations upstream of TERT that could help guide the development of new treatments for melanoma. Full Text | PDF
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