Nature Reviews Molecular Cell Biology contents March 2013 Volume 14 Number 3

TABLE OF CONTENTS
March 2013 Volume 14 Number 3
Impact Factor 39.123 *	In this issue Research Highlights Progress Reviews Perspectives Also this month Article series: DNA damage  Featured article: The road to maturation: somatic cell interaction and self-organization of the mammalian oocyte Rong Li & David F. Albertini
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RESEARCH HIGHLIGHTS Top Development: Growing a blood vessel network p127 | doi:10.1038/nrm3533 Angiogenic vessel growth is controlled by spatially restricted VEGF receptor endocytosis. PDF Non-coding RNA: RNA stability control by Pol II p128 | doi:10.1038/nrm3521 RNA polymerase II acts as a RNA-dependent RNA polymerase to control RNA stability. PDF Plant cell biology: Mobile miRNAs for stem cell maintenance p128 | doi:10.1038/nrm3529 miR394 signals from the protoderm to maintain stem cell activity at the shoot apex. PDF Cell signalling: Putting the brakes on sonic hedgehog p129 | doi:10.1038/nrm3527 A role for GPR161 in the basal repression of sonic hedgehog signalling. PDF Organelle dynamics: Deubiquitylating mitofusin p130 | doi:10.1038/nrm3524 Identifies sites of Fzo1 ubiquitylation and DUBs that counteract this to influence mitochondrial fusion. PDF Cellular microbiology: Mycobacterium leprae turns back the clock p130 | doi:10.1038/nrm3526 M. leprae triggers reprogramming of Schwann cells to promote its dissemination. PDF Meiosis: 'Reigning in' meiotic DNA repair p132 | doi:10.1038/nrm3530 Spp1 recruits potential double-strand break sites to the repair machinery during meiosis. PDF DNA damage: Limiting 53BP1 p132 | doi:10.1038/nrm3532 Histone acetylation regulates BRCA1 and 53BP1 localization to DNA double-strand breaks. PDF IN BRIEF Cytoskeleton: Discrimination for a good cause | Cell adhesion: α-catenin form and function | Post-translational modifications: Dishing up the right protein to the proteasome | Mitosis: Coordinating ciliary dynamics and cell proliferation | Development: Mitotic cell rounding as a morphogenetic switch | Technology: Proteomics gets more selective PDF Molecular Cell Biology JOBS of the week Bio / informatician in Molecular Medicine CEITEC - Central European Institut of Technology Evolutionary & Molecular Developmental Genetics of skin appendages & colour patterns in reptiles University of Geneva - Switzerland Postdoctoral Positions - Taste Molecular Biology Monell Chemical Senses Center Postdoctoral Associate in Molecular Cell Biology Weill Cornell Medical College in Qatar Postdoctoral studies in molecular exercise physiology Karolinska Institutet More Science jobs from Molecular Cell Biology EVENT TM's 2nd world molecular & cell biology online conference 05.-08.02.13 Online More science events from
PROGRESS		Top
Amino acid signalling upstream of mTOR Jenna L. Jewell, Ryan C. Russell & Kun-Liang Guan p133 | doi:10.1038/nrm3522 Amino acids are one of the key environmental stimuli signalling to mTOR. Although exactly how they are sensed and how they activate mTOR has remained elusive, a model has emerged that implicates signalling by RAG GTPases, Ragulator and v-ATPase at the lysosome and leucyl t-RNA synthetase in the cytoplasm. Abstract | Full Text | PDF
REVIEWS		Top
The road to maturation: somatic cell interaction and self-organization of the mammalian oocyte Rong Li & David F. Albertini p141 | doi:10.1038/nrm3531 The growth and maturation of mammalian oocytes rely on the communication with ovarian somatic cells as well as on dynamic cytoskeleton-based events. Increasing evidence suggests that self-organizing microtubules and motor proteins direct meiotic spindle assembly and actin filaments control spindle positioning and oocyte polarity, while meiotic chromatin provides key instructive signals. Abstract | Full Text | PDF
Alternative splicing: a pivotal step between eukaryotic transcription and translation Alberto R. Kornblihtt, Ignacio E. Schor, Mariano Alló, Gwendal Dujardin, Ezequiel Petrillo & Manuel J. Muñoz p153 | doi:10.1038/nrm3525 The prevalence and physiological importance of alternative splicing in multicellular eukaryotes has led to increased interest in its control. Much has been learnt about how transcription and chromatin structure influence splicing events, as well as the effects of signalling pathways, and this understanding may hold promise for the development of gene therapies. Abstract | Full Text | PDF
Exploring mechanisms of FGF signalling through the lens of structural biology Regina Goetz & Moosa Mohammadi p166 | doi:10.1038/nrm3528 Structural data has provided insight into the molecular mechanisms that modulate fibroblast growth factor (FGF) signalling to generate distinct biological outputs in development, tissue homeostasis and metabolism. Mechanisms include alternative splicing of ligand and receptor, homodimerization and site-specific proteolytic cleavage of ligand, and interaction of ligand and receptor with heparan sulphate and Klotho co-receptors. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Article series: DNA damage Charity begins at home: non-coding RNA functions in DNA repair Dipanjan Chowdhury, Young Eun Choi & Marie Eve Brault p181 | doi:10.1038/nrm3523 Both microRNAs (miRNAs) and other small non-coding RNAs (ncRNAs) are induced by DNA breaks and have been linked to the DNA damage response. This interplay between ncRNAs and repair factors may help to ensure efficient DNA repair and maintenance of genome stability. Abstract | Full Text | PDF
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