Nature Reviews Genetics Contents Month 2013 Volume 14 Number 3 pp 151-235

TABLE OF CONTENTS
March 2013 Volume 14 Number 3
Impact Factor 38.075 *	In this issue Research Highlights Reviews Perspectives Also this month Article Series: Computational tools  Featured article: DNA methylation: roles in mammalian development Zachary D. Smith & Alexander Meissner
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Epigenetics: Why histone modifications matter in health and disease February 26 10am EST | 3pm GMT Histones are an integral part of chromatin as they make up the 'protein spools' DNA is wound around. Two prominent speakers will explore one of the key questions in chromatin biology: how the language of post translational modifications on histones influences gene expression. Register for FREE
RESEARCH HIGHLIGHTS Top Gene regulation: Enhancing the hunt for enhancers p151 | doi:10.1038/nrg3426 PDF Genome evolution: The social chromosome p152 | doi:10.1038/nrg3427 PDF Alternative splicing: Regulating Alu element 'exonization' p152 | doi:10.1038/nrg3428 PDF Circadian genetics: Translation gets timely p153 | doi:10.1038/nrg3429 PDF Disease genetics: Y-linked duplication p154 | doi:10.1038/nrg3430 PDF Signalling: Transcription factors tune in p154 | doi:10.1038/nrg3431 PDF Genetic screens: RNA-seq into the toolkit p154 | doi:10.1038/nrg3432 PDF IN BRIEF Development: DNA methylation and female puberty | Epigenetics: Epigenomics road map | Genomics: Finding Mr Anonymous | Small RNAs: A tumour-suppressive tRNA fragment | DNA methylation: Plant immune system uses demethylation | Synthetic biology: Small RNAs improve metabolic engineering | Gene expression: Complete proteome for quantitative trait analysis | Disease genetics: Rare inherited mutations in autism PDF Genetics JOBS of the week Assistant Professors of Human Genetics University of Pittsburgh, Department of Human Genetics, Graduate School of Public Health postdoc / assistant Dalhousie University Post doctoral fellow Mount Sinai School of Medicine Faculty Position in Ecology and Evolutionary Biology University of California Bioinformatics Officer in Cancer (Gene Function Team) The Institute of Cancer Research (ICR) More Science jobs from Genetics EVENT Malaria Experimental Genetics 03.03.13 Cambridge, UK More science events from
REVIEWS		Top
Article series: Computational tools Sequence assembly demystified Niranjan Nagarajan & Mihai Pop p157 | doi:10.1038/nrg3367 As the use of next-generation sequencing has proliferated, so has the range of sequencing applications and software tools that are available for assembling sequences. To help readers to make informed choices about assembly techniques, this Review discusses the available options and practical trade-offs. Abstract | Full Text | PDF | Supplementary information
Genotype to phenotype: lessons from model organisms for human genetics Ben Lehner p168 | doi:10.1038/nrg3404 A key challenge in genetics is predicting variation in phenotypic traits from the genome sequences of individuals. Work in model organisms indicates that a combination of genetic information and in vivo measurements of biological states will be essential for useful phenotypic predictions, including in humans. Abstract | Full Text | PDF
Q ST-F ST comparisons: evolutionary and ecological insights from genomic heterogeneity Tuomas Leinonen, R. J. Scott McCairns, Robert B. O'Hara & Juha Merilä p179 | doi:10.1038/nrg3395 Comparisons of quantitative trait (Q ST) and neutral molecular marker (F ST) divergence allow genetic drift and natural selection to be distinguished between as causes of population differentiation. Q ST-F ST comparisons are being increasingly used to tackle a range of evolutionary and ecological questions. Abstract | Full Text | PDF | Supplementary information
Organization and segregation of bacterial chromosomes Xindan Wang, Paula Montero Llopis & David Z. Rudner p191 | doi:10.1038/nrg3375 Bacterial chromosomes were originally thought to be unstructured and largely unconstrained, but recent advances have supplemented historical research to reveal a highly structured and dynamic chromosome organization. This Review discusses our latest understanding of bacterial chromosome organization, including how the simultaneous nature of DNA replication and chromosome segregation in bacteria necessitates intricate interplay between these processes. Abstract | Full Text | PDF
DNA methylation: roles in mammalian development Zachary D. Smith & Alexander Meissner p204 | doi:10.1038/nrg3354 Advances in epigenomic and genetic studies have shown that DNA methylation undergoes local and global changes during mammalian development. This Review discusses the dynamics of this important epigenetic modification across various developmental stages. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Evaluating evolutionary models of stress-induced mutagenesis in bacteria R. Craig MacLean, Clara Torres-Barceló & Richard Moxon p221 | doi:10.1038/nrg3415 In this Opinion article, the authors discuss models that could explain the evolution of stress-induced mutagenesis in bacteria. They include a new model that argues that genetic drift could have a role in the evolution of low-fidelity DNA polymerases. Abstract | Full Text | PDF | Supplementary information
VIEWPOINT Transgenerational epigenetic inheritance: how important is it? Ueli Grossniklaus, Bill Kelly, Anne C. Ferguson-Smith, Marcus Pembrey & Susan Lindquist p228 | doi:10.1038/nrg3435 How much transgenerational epigenetic inheritance takes place, and what impact does this have on organisms? We asked five leading researchers [mdash] working on key model organisms and on human disease [mdash] for their views. Abstract | Full Text | PDF
Corrigendum: The telomere syndromes Mary Armanios & Elizabeth H. Blackburn p235 | doi:10.1038/nrg3436 Full Text | PDF
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