Nature Reviews Cancer content March 2013 Volume 13 Number 3 pp 145-518

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TABLE OF CONTENTS
March 2013 Volume 13 Number 3		Advertisement
Impact Factor 37.545 *	In this issue Research Highlights Progress Reviews Perspectives Also this month Article series: Models of cancer Genomic instability in cancer  Featured article: Tracking cells in their native habitat: lineage tracing in epithelial neoplasia Maria P. Alcolea & Philip H. Jones	Find out what your cytometer can do for you. You've got the green light to trade in your existing cytometer – regardless of make or model – for more value, discounts, upgrades, and capabilities from BD Biosciences. For a limited time, you can take advantage of exceptional packages with our special trade-in, trade-up program. Learn more today. bdbiosciences.com/go/greenlight
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BEATSON INTERNATIONAL CANCER CONFERENCE Targeting the Tumour Stroma 7 - 10 July 2013 Glasgow University This meeting will highlight recent exciting research into the role played by the tumour stroma in cancer progression and how stromal tissue may be targeted to treat the disease. Deadline for registration, payment and abstract submission - 6 May 2013
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Published research in BJC makes the BBC news Differences in cancer awareness and beliefs between Australia, Canada, Denmark, Norway, Sweden and the UK (the International Cancer Benchmarking Partnership): do they contribute to differences in cancer survival? L Forbes et al.
RESEARCH HIGHLIGHTS Top Microenvironment: An accommodating host p145 | doi:10.1038/nrc3470 Survival of chronic lymphocytic leukaemia cells depends on the activation of protein kinase C βII and nuclear factor-κB signalling in stromal cells, and this pathway is a potential therapeutic target for this and other haematological malignancies. PDF Ubiquitylation: Mediation by degradation p146 | doi:10.1038/nrc3471 Bruce Clurman and colleagues have found that FBXW7, a subunit of the SCF ubiquitin ligase, interacts with components of the Mediator complex and so it might be involved in regulating gene transcription. PDF TRIAL WATCH Moving forwards p146 | doi:10.1038/nrc3476 Joseph Tabernero and colleagues have carried out a 'first-in-man' Phase I trial of two small interfering RNAs (siRNAs) to treat patients with refractory metastatic disease that involves the liver. PDF DNA damage: In at the beginning p147 | doi:10.1038/nrc3472 Early replicating fragile sites can contribute to the genetic translocations and copy number alterations that are often seen in B cell lymphomas. PDF Tumorigenesis: All together now p148 | doi:10.1038/nrc3469 Three recently published papers have strived to address more precisely the inflammatory pathways that contribute to the initiation and development of colorectal cancer. PDF Breast cancer: Circulating and dynamic EMT p148 | doi:10.1038/nrc3475 A new study characterizes the epithelial versus mesenchymal properties of circulating tumour cells and identifies an interesting plasticity. PDF Senescence: Improved detection p150 | doi:10.1038/nrc3473 Expression of luciferase at the locus encoding the senescence-promoter and tumour suppressor INK4A allows for robust, non-invasive detection of early tumorigenesis in mouse models. PDF Tumour immunology: Give it a rest p150 | doi:10.1038/nrc3474 Braumuller, Wieder and colleagues show that T helper 1 cells induce the senescence of tumour cells. PDF Therapeutic resistance: ALL-important mutations p151 | doi:10.1038/nrc3478 Two groups have found that mutations in NT5C2 (which encodes the enzyme cytosolic purine 5′-nucleotidase) are selected for in relapsed acute lymphoblastic leukaemia and may contribute to resistance to two commonly used chemotherapeutics. PDF IN BRIEF Tumour suppressors: FAT loss lets WNT get active | Epigenetics: Methylation in the driver's seat? | Splicing: Chimeric expression | Genetics: Promoter mutations PDF Cancer JOBS of the week Cancer Research Faculty Position Tulane University Cancer Center Postdoc in Cancer Proteomics University Health Network/University of Toronto Glycomic Mass Spectrometry of Ovarian Cancer University of Gothenburg/Sahlgrenska Academy Post-Doctoral Fellowships in Basic and Translational Neuro-Oncology The Feinstein Institute for Medical Research Postdoctoral Research Fellow Beth Israel Deacon Medical Center - Harvard Medical School More Science jobs from Cancer EVENT 1st Symposium of the Cancer Research Center of Lyon 13.-15.02.13 Lyon, France More science events from
PROGRESS		Top
BAP1 and cancer Michele Carbone, Haining Yang, Harvey I. Pass, Thomas Krausz, Joseph R. Testa & Giovanni Gaudino p153 | doi:10.1038/nrc3459 BAP1 is a deubiquitylase that is associated with multiprotein complexes that regulate key cellular pathways. Recent findings have indicated that germline BAP1 mutations might cause a novel cancer syndrome. Michele Carbone and colleagues discuss the evidence for this. Abstract | Full Text | PDF
REVIEWS		Top
Tracking cells in their native habitat: lineage tracing in epithelial neoplasia Maria P. Alcolea & Philip H. Jones p161 | doi:10.1038/nrc3460 This Review discusses how genetic lineage tracing can be used to quantify the behaviour of normal, preneoplastic and tumour cells in epithelia in transgenic mice. It also discusses some of the limitations of lineage tracing in mouse models of cancer. Abstract | Full Text | PDF
Article series: Models of cancer Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics Cayetano Gonzalez p172 | doi:10.1038/nrc3461 Drosophila melanogaster has often provided the first glimpse into the mechanism of action of human cancer-related proteins. In addition, D. melanogaster strains engineered to recapitulate key aspects of specific types of human cancer are providing us with further insights into malignancy, and serving as platforms for drug discovery. Abstract | Full Text | PDF
Molecular pathogenesis and mechanisms of thyroid cancer Mingzhao Xing p184 | doi:10.1038/nrc3431 There have been substantial advances in understanding the molecular pathogenesis of thyroid cancer, which have provided insights into genetic and epigenetic alterations in this cancer and into PI3K and MAPK signalling, for example. This Review discusses these findings and the implications for novel treatment of thyroid cancer. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Article series: Genomic instability in cancer In the wrong place at the wrong time: does cyclin mislocalization drive oncogenic transformation? Jonathan D. Moore p201 | doi:10.1038/nrc3468 Cyclins control the activity of cyclin-dependent kinases, which drive cell cycle progression. The expression of cyclins can be disrupted in cancer cells, and this Opinion article discusses the possibility that altered subcellular localization of cyclins may also affect cell cycle progression and genomic stability. Abstract | Full Text | PDF
OPINION Prostate cancer: is it time to expand the research focus to early-life exposures? Siobhan Sutcliffe & Graham A. Colditz p208 | doi:10.1038/nrc3434 Although we understand various aspects of prostate cancer biology, few reliable risk factors are known. This Opinion article rationalizes why exposures early in life may be key for prostate cancer risk, summarizes our current limited understanding of early-life exposures and provides visions for the future. Abstract | Full Text | PDF
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` Epigenetics: Why histone modifications matter in health and disease February 26 10am EST | 3pm GMT Histones are an integral part of chromatin as they make up the 'protein spools' DNA is wound around. Two prominent speakers will explore one of the key questions in chromatin biology: how the language of post translational modifications on histones influences gene expression. Register for FREE
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*2011 Journal Citation Report (Thomson Reuters, 2012)

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